Results 61 to 70 of about 9,338 (256)

Polymerase Synthesis of Hypermodified DNA Displaying a Combination of Thiol, Hydroxyl, Carboxylate, and Imidazole Functional Groups in the Major Groove

Chemistry – A European Journal, EarlyView.
A series of 2’‐deoxyribonucleoside 5’‐O‐triphosphates bearing functional groups of amino acid side chains in enzyme active sites (OH, SH, COOH, and imidazole) were synthesized and used for enzymatic synthesis of hypermodified DNA displaying these substituents in the major groove mimicking peptides or proteins. Abstract We designed and synthesized a set
Lukáš Kaiser, Marek Ondruš, Lenka Poštová Slavětínská, Veronika Raindlová, Michal Hocek   +4 more
wiley   +1 more source

Innovative Cyclic Nucleotides – Nucleoside 2′,3′‐Seven‐Membered Cyclic Diphosphonate Derivatives. Theoretical Feasibility, Synthesis, and Properties

Chemistry – A European Journal, EarlyView.
First report on 7‐membered cyclic nucleotides, 2',3'‐cNTDPs, obtained from all‐natural free ribonucleosides in robust, step‐economic synthesis involving instantaneous and regio‐selective reaction. DFT calculations confirmed the feasibility of 7‐membered cyclic nucleotide formation and deciphered the basis for regioselectivity.
Sveta Liberman, Lea Bobot, Hadar T Ben Daniel, Dan T Major, Bilha Fischer   +4 more
wiley   +1 more source

Structural and Functional Basis of the Fidelity of Nucleotide Selection by Flavivirus RNA-Dependent RNA Polymerases

Viruses, 2018
Viral RNA-dependent RNA polymerases (RdRps) play a central role not only in viral replication, but also in the genetic evolution of viral RNAs. After binding to an RNA template and selecting 5′-triphosphate ribonucleosides, viral RdRps synthesize an RNA ...
Barbara Selisko, Nicolas Papageorgiou, François Ferron, Bruno Canard   +3 more
doaj   +1 more source

Alkbh8 Regulates Selenocysteine-Protein Expression to Protect against Reactive Oxygen Species Damage [PDF]

, 2015
Environmental and metabolic sources of reactive oxygen species (ROS) can damage DNA, proteins and lipids to promote disease. Regulation of gene expression can prevent this damage and can include increased transcription, translation and post translational
Begley, Thomas J., Begley, Ulrike, Clark, Ryan, Dedon, Peter C., Dziergowska, Agnieszka, Endres, Lauren, Gu, Chen, Małkiewicz, Andrzej, Melendez, J. Andres   +8 more
core   +3 more sources

Annual Banned‐Substance Review 17th Edition—Analytical Approaches in Human Sports Drug Testing 2023/2024

Drug Testing and Analysis, EarlyView.
Scenarios of drug exposure and administration as well as detection assays for drugs and methods of sports doping published between 2023 and 2024 are critically reviewed and evaluated in context with the Prohibited List 2024 as established by the World Anti‐Doping Agency.
Mario  Thevis, Tiia  Kuuranne, Hans  Geyer   +2 more
wiley   +1 more source

Cardiomyocytes disrupt pyrimidine biosynthesis in nonmyocytes to regulate heart repair

The Journal of Clinical Investigation, 2022
Various populations of cells are recruited to the heart after cardiac injury, but little is known about whether cardiomyocytes directly regulate heart repair.
Shen Li, Tomohiro Yokota, Ping Wang, Johanna ten Hoeve, Feiyang Ma, Thuc M. Le, Evan R. Abt, Yonggang Zhou, Rimao Wu, Maxine Nanthavongdouangsy, Abraham Rodriguez, Yijie Wang, Yen-Ju Lin, Hayato Muranaka, Mark Sharpley, Demetrios T. Braddock, Vicky E. MacRae, Utpal Banerjee, Pei-Yu Chiou, Marcus Seldin, Dian Huang, Michael Teitell, Ilya Gertsman, Michael Jung, Steven J. Bensinger, Robert Damoiseaux, Kym Faull, Matteo Pellegrini, Aldons J. Lusis, Thomas G. Graeber, Caius G. Radu, Arjun Deb   +31 more
doaj   +1 more source

Biomolekulák analízise kapilláris elektroforézissel - Módszertani tanulmányok [PDF]

, 2001
7
Végvári Ákos
core  

Degradation of nucleic acids with ozone. I. Degradation of nucleobases,ribonucleosides and ribonucleoside-5'-monophosphates.

Chemical and Pharmaceutical Bulletin, 1981
The degradation of nucleobases, ribonucleosides and ribonucleotides with ozone was examined as a model of the action of ozone on nucleic acids. The degradation rates of nucleobases were in the following order : G, T>U>C>A. Nucleosides and nucleotides were degraded in the same order as in the corresponding nucleobases.
Tohru Ueda, Akira Ikehata, Kozo Ishizaki, Nariko Shinriki   +3 more
openaire   +3 more sources

Decoding RNA–Protein Interactions: Methodological Advances and Emerging Challenges

Advanced Genetics, EarlyView.
This review provides a comprehensive comparison of RNA‐ and protein‐centric methodologies for investigating RNA–protein interactions, emphasizing their respective advantages, limitations, and suitable applications. It highlights recent technological innovations, outlines strategic method selection criteria, and addresses key challenges.
Wenkai Yi, Jian Yan
wiley   +1 more source

Pentavalent Antimonials: New Perspectives for Old Drugs

Molecules, 2009
Pentavalent antimonials, including meglumine antimoniate and sodium stibogluconate, have been used for more than half a century in the therapy of the parasitic disease leishmaniasis.
Raul R. Ribeiro, Cynthia Demicheli, Frédéric Frézard   +2 more
doaj   +1 more source