Results 61 to 70 of about 6,161 (198)

A Convenient Synthesis of Ribonucleoside 2', 3', -Cyclic Phosphates from Ribonucleosides and Ribonucleotides

Chemical and Pharmaceutical Bulletin, 1970
Adenosine 5'-phosphate was converted to the 2', 3'-cyclic phosphate by the treatment with dimethylformamide at reflux temperature. The reaction was shown to be proceeded by the initial release of the phosphoryl group as an"activated phosphoric acid"and rephosphorylated to furnish the 2', 3'-cyclic phosphate. In fact a ribonucleoside and phosphoric acid,
TOHRU UEDA, IKUKO KAWAI
openaire   +2 more sources

Synthetic Strategies to Access Fluorinated Azoles

European Journal of Organic Chemistry, Volume 28, Issue 47, December 15, 2025.
This review highlights recent synthetic strategies for introducing fluorine groups (mono‐, di‐, and trifluoromethylation) into 11 major azole classes, identifying research gaps to inform future innovations in materials science, medicinal chemistry, and biomedical research.
Mohammed K. Abd El‐Gaber, Mario Djugovski, Tzu‐Yu Huang, Sweta Adhikari, Sudeshna Roy   +4 more
wiley   +1 more source

Regular versus Irregular Exercise Differentially Modulates Hippocampal‐Hepatic Acetylcholine Flux to Coordinate Fear Memory Extinction and Liver Inflammation

Advanced Science, Volume 12, Issue 45, December 4, 2025.
Ma et al. report the hippocampal and hepatic acetylcholine (ACh) levels are differently modulated by regular versus irregular exercise, which contributes to coordinate hippocampal astrocyte activity and hepatic FBXL6high neutrophil recruitment. This ACh‐modulated brain‐liver circuit links the effects of exercise on fear memory extinction and liver ...
Pengjiao Ma, Kuan Zhang, Long Yi, Chuanyan Yang, Hedong Lang, Jianbin Sun, Jin Li, Qian Bai, Yuhang He, Shuang‐Shuang Dai, Man‐Tian Mi   +10 more
wiley   +1 more source

Mechanochemical Reactivity of Ribonucleosides Mediated by Inorganic Species: Implications for Extraterrestrial Organic Matter Interpretation

Applied Sciences
Metal species and carbonate are often found as minerals in extraterrestrial rocky bodies. Based on this, the mechanochemical-induced degradation of canonical purine and pyrimidine ribonucleosides into their corresponding nucleobases mediated by some of ...
Gustavo P. Maia, Catarina Gonçalves, Ana J. Carvalho, Vânia André, Adelino Galvão, Ana P. C. Ribeiro, Pedro F. Pinheiro, José Armando Luísa da Silva   +7 more
doaj   +1 more source

Degradation of nucleic acids with ozone. I. Degradation of nucleobases,ribonucleosides and ribonucleoside-5'-monophosphates.

Chemical and Pharmaceutical Bulletin, 1981
The degradation of nucleobases, ribonucleosides and ribonucleotides with ozone was examined as a model of the action of ozone on nucleic acids. The degradation rates of nucleobases were in the following order : G, T>U>C>A. Nucleosides and nucleotides were degraded in the same order as in the corresponding nucleobases.
K, Ishizaki, N, Shinriki, A, Ikehata, T, Ueda   +3 more
openaire   +2 more sources

In vitro DNA/RNA Adductomics to Confirm DNA Damage Caused by Benzo[a]pyrene in the Hep G2 Cell Line

Frontiers in Chemistry, 2019
In the development of new chemical substances, genetic toxicity evaluations are a high priority for safety risk management. Evaluation of the possibility of compound carcinogenicity with accuracy and at reasonable cost in the early stages of development ...
Toshihide Takeshita, Robert A. Kanaly
doaj   +1 more source

INTRACELLULAR Leishmania amazonensis KILLING INDUCED BY THE GUANINE NUCLEOSIDE 8-BROMOGUANOSINE

Revista do Instituto de Medicina Tropical de São Paulo, 1998
In this study we investigated the effect of 8-Bromoguanosine, an immunostimulatory compound, on the cytotoxicity of macrophages against Leishmania amazonensis in an in vitro system. The results showed that macrophages treated with 8-Bromoguanosine before
GIORGIO Selma, BARÃO Sandra C.
doaj  

Properties of Ribonucleoside Diphosphate Reductase in Nucleotide-Permeable Cells [PDF]

, 1973
Huber R. Warner
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Structure–Functional Examination of Novel Ribonucleoside Hydrolase C (RihC) from Limosilactobacillus reuteri LR1 [PDF]

, 2023
Leonid A. Shaposhnikov, N. Yu. Chikurova, D. L. Atroshenko, С. С. Савин, Sergey Y. Kleymenov, A. V. Chernobrovkina, E. V. Pometun, Mikhail E. Minyaev, Ilya O. Matyuta, Dmitry M. Hushpulian, Konstantin M. Boyko, В. И. Тишков, A. A. Pometun   +12 more
openalex   +1 more source

Role of salvage and phosphorylation in the immunostimulatory activity of C8-substituted guanine ribonucleosides. [PDF]

, 1988
Michael Goodman
openalex   +1 more source