Results 231 to 240 of about 492,027 (288)

Alternative Translation Initiation in PRKN Delays the Onset of Parkinson's Disease and Offers a Therapeutic Target

Annals of Neurology, EarlyView.
Objective Biallelic variants in PRKN cause autosomal recessive Parkinson's disease (PD) with a median age at onset of 31 years. When evaluating the 16 previously published carriers of a homozygous deletion of Exon 2 from the International Parkinson's Disease and Movement Disorder Society Gene Database (MDSGene) database, the median age at onset is ...
Arian Hach, Katja Lohmann, Manabu Funayama, Poornima J. Menon, Eva‐Juliane Vollstedt, Teresa Kleinz, Hiroyo Yoshino, Suzanne Lesage, Britta Meier, Carolyn M. Sue, Jean‐Christophe Corvol, Alexis Brice, Nobutaka Hattori, Christine Klein, Aleksandar Rakovic   +14 more
wiley   +1 more source

The complete mitochondrial genome sequence of <i>Trichoderma texanum</i> (Hypocreales, Sordariomycetes). [PDF]

Mitochondrial DNA B Resour
Dalantai M, Oh SY.
europepmc   +1 more source

Decoding the Pathophysiology of Autoimmune Diseases—Mechanism, Triggers, and Nanotherapeutics: A Review

Advanced NanoBiomed Research, EarlyView.
This review highlights how autoimmune diseases arise from intertwined immunological, genetic, and environmental factors, emphasizing gut microbiota dysbiosis as a pivotal driver. It outlines emerging nanotechnology‐based strategies—such as liposomes, hydrogels, and polymeric nanoparticles—that enhance targeted drug delivery, minimize systemic toxicity,
Md. Meraj Ansari, Yunhui Min, Eun‐Ju Ko, Doyoung Kwon, Rehan Khan, Young‐Ok Son   +5 more
wiley   +1 more source

Nitroxide Hormesis in Yeast: 4-Hydroxy-TEMPO Modulates Aging, and Cell Cycle. [PDF]

Molecules
Mołoń M, Kielar P, Molestak E, Mołoń A, Kuna E, Biesiadecki M, Grela P, González-Ibarra A, Galiniak S.   +8 more
europepmc   +1 more source

Reference gene variability across age and sex in 5XFAD mice highlights normalization challenges in Alzheimer's models. [PDF]

Sci Rep
Daini E, Antonioni K, Piemontese M, Bodria M, Zoli M, Vilella A.   +5 more
europepmc   +1 more source

Unsaturated Phosphorus Electrophiles to Probe Protein Tyrosine Phosphatases

Angewandte Chemie International Edition, EarlyView.
Charged aryl‐ethynyl phosphonamidic and phosphonic acids are introduced as low‐reactivity electrophiles for peptide‐based activity probes that enable selective, target‐specific profiling of protein tyrosine phosphatases. The probes show no off‐target cysteine reactivity and engage only the interacting phosphatase in global proteomic analysis.
Eleftheria Poulou, Max Ruwolt, Christian E. Stieger, Kristin Kemnitz‐Hassanin, Christian P. R. Hackenberger   +4 more
wiley   +1 more source

Exploring the regulatory potential of RNA structures in 202 cyanobacterial genomes. [PDF]

Nucleic Acids Res
Geissler AS, Carrasquer-Alvarez E, Anthon C, Frigaard NU, Gorodkin J, Seemann SE.   +5 more
europepmc   +1 more source

Compensation Response to Hepatic Gluconeogenesis via β‐Hydroxybutyrylation of FBP1 and PCK1 in Dairy Cows

Animal Research and One Health, EarlyView.
(1) Kbhb modification of FBP1 and PCK1 is involved in regulation of the gluconeogenesis pathway. (2) Kbhb of FBP1 and PCK1 is catalyzed by p300 and removed by HDACs. (3) BHB induced an increase in the enzymatic activity of FBP1 and PCK1 through Kbhb modification at the K43 site of FBP1 and the K191 site of PCK1.
DingPing Feng, GuoYan Wang, YuanYuan Zhu, YiNing Zheng, JunHu Yao, Lei Chen, Lu Deng   +6 more
wiley   +1 more source

Spatial regulation of ribosomal protein gene expression revealed by spatial transcriptomic analysis in the water fern <i>Ceratopteris richardii</i>. [PDF]

Front Plant Sci
Han J, Li GS.
europepmc   +1 more source

Exploring the Roles of Tuna‐Associated Acinetobacter sp. YFT067: Implications for Host Health and Metabolism

Animal Research and One Health, EarlyView.
This study firstly isolated a tuna‐derived gut probiotic Acinetobacter seifertii YFT067. Dietary administration of YFT067 played significant roles in promoting growth performance, SCFAs production, lipid absorption, and metabolism of the host, indicating YFT067 as a promising probiotic candidate for enhancing tuna aquaculture productivity through ...
Ying Zou, Hai Huang, Qiongyao Fu, Zhiyuan Lu, Zhiqiang Guo   +4 more
wiley   +1 more source