Results 31 to 40 of about 406,930 (327)

Kinetic modeling predicts a stimulatory role for ribosome collisions at elongation stall sites in bacteria

open access: yeseLife, 2017
Ribosome stalling on mRNAs can decrease protein expression. To decipher ribosome kinetics at stall sites, we induced ribosome stalling at specific codons by starving the bacterium Escherichia coli for the cognate amino acid. We measured protein synthesis
Michael A Ferrin, Arvind R Subramaniam
doaj   +1 more source

Functional Analysis of PSRP1, the Chloroplast Homolog of a Cyanobacterial Ribosome Hibernation Factor

open access: yesPlants, 2020
Bacterial ribosome hibernation factors sequester ribosomes in an inactive state during the stationary phase and in response to stress. The cyanobacterial ribosome hibernation factor LrtA has been suggested to inactivate ribosomes in the dark and to be ...
Kevin Swift   +4 more
doaj   +1 more source

The 73 S ribosome of Neurospora crassa is the native mitochondrial ribosome [PDF]

open access: yes, 1977
The effect of the inclusion of EDTA and of heparin, in media used in the isolation of mitochondria, on the mitochindrial previous termribosomenext term has been investigated. 1. 1.
Adelmann   +24 more
core   +1 more source

Cotranslational folding of proteins on the ribosome.

open access: yes, 2020
Many proteins in the cell fold cotranslationally within the restricted space of the polypeptide exit tunnel or at the surface of the ribosome. A growing body of evidence suggests that the ribosome can alter the folding trajectory in many different ways ...
Liutkute, M., Rodnina, M., Samatova, E.
core   +1 more source

A Network-Guided Genetic Approach to Identify Novel Regulators of Adventitious Root Formation in Arabidopsis thaliana

open access: yesFrontiers in Plant Science, 2019
Adventitious roots (ARs) are formed de novo during post-embryonic development from non-root tissues, in processes that are highly dependent on environmental inputs.
Sergio Ibáñez   +8 more
doaj   +1 more source

Alkylative damage of mRNA leads to ribosome stalling and rescue by trans translation in bacteria

open access: yeseLife, 2020
Similar to DNA replication, translation of the genetic code by the ribosome is hypothesized to be exceptionally sensitive to small chemical changes to its template mRNA.
Erica N Thomas   +4 more
doaj   +1 more source

Exploring Wells-Dawson Clusters Associated With the Small Ribosomal Subunit

open access: yesFrontiers in Chemistry, 2019
The polyoxometalate P2W18O626-, the Wells-Dawson cluster, stabilized the ribosome sufficiently for the crystallographers to solve the phase problem and improve the structural resolution.
Debbie C. Crans   +3 more
doaj   +1 more source

Defining the interactome of the human mitochondrial ribosome identifies SMIM4 and TMEM223 as respiratory chain assembly factors

open access: yeseLife, 2021
Human mitochondria express a genome that encodes thirteen core subunits of the oxidative phosphorylation system (OXPHOS). These proteins insert into the inner membrane co-translationally. Therefore, mitochondrial ribosomes engage with the OXA1L-insertase
Sven Dennerlein   +12 more
doaj   +1 more source

Expansion of a novel population of NK cells with low ribosome expression in juvenile dermatomyositis

open access: yesFrontiers in Immunology, 2022
Juvenile dermatomyositis (JDM) is a pediatric autoimmune disease associated with characteristic rash and proximal muscle weakness. To gain insight into differential lymphocyte gene expression in JDM, peripheral blood mononuclear cells from 4 new-onset ...
Kinsey A. Hilliard   +7 more
doaj   +1 more source

The Ccr4-Not complex monitors the translating ribosome for codon optimality

open access: yesScience, 2019
Coupling translation and mRNA decay Gene expression requires messenger RNAs (mRNAs)—DNA-derived blueprints of genes—to be translated by protein-producing ribosomes. The levels of mRNAs are tightly regulated, in part by controlling their half-lives.
R. Buschauer   +16 more
semanticscholar   +1 more source

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