Results 31 to 40 of about 254,623 (219)

General Approach for Introduction of Various Chemical Labels in Specific RNA Locations Based on Insertion of Amino Linkers

Molecules, 2013
Introduction of reporter groups at designed RNA sites is a widely accepted approach to gain information about the molecular environment of RNAs in their complexes with other biopolymers formed during various cellular processes.
Dmitri Graifer, Galina Karpova
doaj   +1 more source

Comparative Transcriptome Landscape of Mouse and Human Hearts

Frontiers in Cell and Developmental Biology, 2020
Transcriptome landscape of organs from mice and humans offers perspectives on the process of how organs develop and the similarity and diversity in each organ between the species.
Tatsuya Anzai, Tatsuya Anzai, Takanori Yamagata, Hideki Uosaki   +3 more
doaj   +1 more source

Analyzing ribosome remodeling in health and disease [PDF]

PROTEOMICS (2020), 2020
regulation largely unexplored, in part due to methodological limitations. Indeed, we review evidence demonstrating that commonly used methods, such as transcriptomics, are inadequate because the variability in mRNAs coding for ribosomal proteins (RP) does not necessarily correspond to RP variability.
arxiv   +1 more source

The ribosome assembly gene network is controlled by the feedback regulation of transcription elongation [PDF]

, 2017
Ribosome assembly requires the concerted expression of hundreds of genes, which are transcribed by all three nuclear RNA polymerases. Transcription elongation involves dynamic interactions between RNA polymerases and chromatin.
Begley, Victoria Sarah, Chávez de Diego, Sebastián, Cruz Díaz, Jesús de la, Gómez Herreros, Fernando, Holstege, Frank C.P., Margaritis, Thanasis, Millán Zambrano, Gonzalo, Morillo Huesca, Macarena, Muñoz Centeno, María de la Cruz, Pelechano, Vicent, Pérez Ortín, José Enrique, Rodríguez Galán, Olga   +11 more
core   +3 more sources

HCV IRES manipulates the ribosome to promote the switch from translation initiation to elongation. [PDF]

, 2013
The internal ribosome entry site (IRES) of the hepatitis C virus (HCV) drives noncanonical initiation of protein synthesis necessary for viral replication.
A Ben-Shem, A Devaraj, AA Malygin, AD Petropoulos, AY Keel, Breanna S Vollmar, C Chen, CM Spahn, CS Fraser, CS Fraser, D Boehringer, D Hartz, D Sousa, Dan Shi, DD Ian'shina, DV Sizova, EF Pettersen, F Odreman-Macchioli, F Peske, F Robert, GA Otto, GJ Kleywegt, H Ji, IB Lomakin, IM Terenin, J Bukh, J Rabl, J Wower, JA Mindell, JE Wilson, Jeffrey S Kieft, JH Kim, JM Fringer, JR Lytle, JR Lytle, JS Kieft, JS Kieft, K Tsukiyama-Kohara, KE Berry, KI Kalliampakou, LA Passmore, M Honda, M Ohi, M Selmer, M Stoneley, M van Heel, ME Filbin, Megan E Filbin, MG Acker, MM Yusupov, N Grigorieff, N Locker, O Galkin, P Antúnez de Mayolo, P Simmonds, PJ Lukavsky, PJ Lukavsky, RE Monro, RJ Jackson, S Fukushi, S Uemura, SM Dibrov, T Döring, Tamir Gonen, TV Pestova, TV Pestova, U Geigenmüller, VG Kolupaeva, Y Yu   +68 more
core   +1 more source

RNA polymerase I inhibition induces terminal differentiation, growth arrest, and vulnerability to senolytics in colorectal cancer cells

Molecular Oncology, 2022
Ribosomal biogenesis and protein synthesis are deregulated in most cancers, suggesting that interfering with translation machinery may hold significant therapeutic potential. Here, we show that loss of the tumor suppressor adenomatous polyposis coli (APC)
Christoph Otto, Carolin Kastner, Stefanie Schmidt, Konstantin Uttinger, Apoorva Baluapuri, Sarah Denk, Mathias T. Rosenfeldt, Andreas Rosenwald, Florian Roehrig, Carsten P. Ade, Christina Schuelein‐Voelk, Markus E. Diefenbacher, Christoph‐Thomas Germer, Elmar Wolf, Martin Eilers, Armin Wiegering   +15 more
doaj   +1 more source

Abstract OR-15: Structural and Functional Studies of the Staphylococcus aureus Ribosome Hibernation [PDF]

International Journal of Biomedicine, 2019
Background: In bacteria, diminishing of protein synthesis is often accompanied with the formation of ribosomal dimers (or disomes). This process might be particularly important for pathogenic bacteria whose successful survival is a key factor for ...
Konstantin Usachev, Iskander Khusainov, Bulat Fatkhullin, Shamil Validov, Marat Yusupov   +4 more
doaj   +1 more source

Kinetic modeling predicts a stimulatory role for ribosome collisions at elongation stall sites in bacteria

eLife, 2017
Ribosome stalling on mRNAs can decrease protein expression. To decipher ribosome kinetics at stall sites, we induced ribosome stalling at specific codons by starving the bacterium Escherichia coli for the cognate amino acid. We measured protein synthesis
Michael A Ferrin, Arvind R Subramaniam
doaj   +1 more source

A Complementary Mechanism of Bacterial mRNA Translation Inhibition by Tetracyclines

Frontiers in Microbiology, 2021
Tetracycline has positively impacted human health as well as the farming and animal industries. Its extensive usage and versatility led to the spread of resistance mechanisms followed by the development of new variants of the antibiotic.
Victor Barrenechea, Victor Barrenechea, Maryhory Vargas-Reyes, Miguel Quiliano, Pohl Milón   +4 more
doaj   +1 more source

Identifying ribosome heterogeneity using ribosome profiling

Nucleic Acids Research, 2022
Abstract Recent studies have revealed multiple mechanisms that can lead to heterogeneity in ribosomal composition. This heterogeneity can lead to preferential translation of specific panels of mRNAs, and is defined in large part by the ribosomal protein (RP) content, amongst other things.
Ferhat Alkan, Oscar G Wilkins, Santiago Hernández-Pérez, Sofia Ramalho, Joana Silva, Jernej Ule, William J Faller   +6 more
openaire   +6 more sources