Results 41 to 50 of about 406,930 (327)
, 2011 Ribosome is a molecular machine that polymerizes a protein where the sequence of the amino acid residues, the monomers of the protein, is dictated by the sequence of codons (triplets of nucleotides) on a messenger RNA (mRNA) that serves as the template ...
Ajeet K Sharma +10 more
core +1 more source
Engineering stochasticity in gene expression [PDF]
, 2008 Stochastic fluctuations (noise) in gene expression can cause members of otherwise genetically identical populations to display drastically different phenotypes. An understanding of the sources of noise and the strategies cells employ to function reliably
Bayer, Travis S. +4 more
core +1 more source
The Organizing Principles of Eukaryotic Ribosome Recruitment.
Annual Review of Biochemistry, 2019 The stage at which ribosomes are recruited to messenger RNAs (mRNAs) is an elaborate and highly regulated phase of protein synthesis. Upon completion of this step, a ribosome is positioned at an appropriate initiation codon and primed to synthesize the ...
J. Pelletier, N. Sonenberg
semanticscholar +1 more source
Ribosome collisions trigger cis-acting feedback inhibition of translation initiation
eLife, 2020 Translation of aberrant mRNAs can cause ribosomes to stall, leading to collisions with trailing ribosomes. Collided ribosomes are specifically recognised by ZNF598 to initiate protein and mRNA quality control pathways.
S. Juszkiewicz +5 more
semanticscholar +1 more source
A creature with a hundred waggly tails: intrinsically disordered proteins in the ribosome [PDF]
, 2013 This article is made available for unrestricted research re-use and secondary analysis in any form or by any means with acknowledgement of the original source.
Dunker, A. Keith +6 more
core +2 more sources
Selective 40S Footprinting Reveals Cap-Tethered Ribosome Scanning in Human Cells.
Molecules and Cells, 2020 Translation regulation occurs largely during the initiation phase. Here, we develop selective 40S footprinting to visualize initiating 40S ribosomes on endogenous mRNAs in vivo.
J. Bohlen +4 more
semanticscholar +1 more source
YoeB toxin is activated during thermal stress. [PDF]
, 2015 Type II toxin-antitoxin (TA) modules are thought to mediate stress-responses by temporarily suppressing protein synthesis while cells redirect transcription to adapt to environmental change.
Garza-Sánchez, Fernando +2 more
core +1 more source
A binding site for the antibiotic GE81112 in the ribosomal mRNA channel
mBioThe initiation phase is the rate-limiting step of protein synthesis (translation) and is finely regulated, making it an important drug target. In bacteria, initiation is guided by three initiation factors and involves positioning the start site on the ...
Andreas Schedlbauer +15 more
doaj +1 more source
RNA Biology, 2016 rRNAs are extensively modified during their transcription and subsequent maturation in the nucleolus, nucleus and cytoplasm. RNA modifications, which are installed either by snoRNA-guided or by stand-alone enzymes, generally stabilize the structure of ...
K. Sloan +5 more
semanticscholar +1 more source
The Prospects for Immigration Amendments [PDF]
, 1956 Obg proteins are a family of P-loop GTPases, conserved from bacteria to human. The Obg protein in Escherichia coli (ObgE) has been implicated in many diverse cellular functions, with proposed molecular roles in two global processes, ribosome assembly and
Cao, Wei +12 more
core +4 more sources