Results 51 to 60 of about 176,411 (317)

Characterization of ribosome heterogeneity during endothelial to hematopoietic transition

FEBS Open Bio, EarlyView.
The panorama of ribosome heterogeneity during embryonic hematopoiesis has not yet been portrayed. In this study, utilizing dual‐omics data, the heterogenous dynamic of ribosome during endothelial‐to‐hematopoietic transition has been systemically described. Moreover, stage‐specific upregulation and peripheral localization of RPL27 and RACK1 in hemogenic
Xitong Tian, Di Liu, Bing Liu, Yu Lan, Jie Zhou   +4 more
wiley   +1 more source

Origin of the Genetic Code Is Found at the Transition between a Thioester World of Peptides and the Phosphoester World of Polynucleotides

Life, 2019
The early metabolism arising in a Thioester world gave rise to amino acids and their simple peptides. The catalytic activity of these early simple peptides became instrumental in the transition from Thioester World to a Phosphate World.
Hyman Hartman, Temple F. Smith
doaj   +1 more source

Liver‐specific lncRNAs associated with liver cancers

FEBS Open Bio, EarlyView.
Long non‐coding RNAs (lncRNAs) are regulatory molecules with various functions. They are more tissue‐specific than proteins and can be used as potential biomarkers, particularly in cancer diagnostics and prognosis. In this review, we have systematically compiled all lncRNAs with exclusive expression in the human liver, verified their liver specificity ...
Olga Y. Burenina, Roman K. Makarchenko, Maria P. Rubtsova, Olga A. Dontsova   +3 more
wiley   +1 more source

From DNA to proteins via the ribosome: Structural insights into the workings of the translation machinery

Human Genomics, 2010
Understanding protein synthesis in bacteria and humans is important for understanding the origin of many human diseases and devising treatments for them.
Agirrezabala Xabier, Frank Joachim
doaj   +1 more source

Comparative Transcriptome Landscape of Mouse and Human Hearts

Frontiers in Cell and Developmental Biology, 2020
Transcriptome landscape of organs from mice and humans offers perspectives on the process of how organs develop and the similarity and diversity in each organ between the species.
Tatsuya Anzai, Tatsuya Anzai, Takanori Yamagata, Hideki Uosaki   +3 more
doaj   +1 more source

The E3 ubiquitin ligase, RNF219, suppresses CNOT6L expression to exhibit antiproliferative activity

FEBS Open Bio, EarlyView.
We identified RNF219 as a CCR4‐NOT complex‐interacting E3 ubiquitin ligase that targets the CCR4‐NOT subunit CNOT6L for ubiquitination. RNF219 directly binds to the DUF3819 domain of CNOT1 through its putative α‐helix spanning amino acids 521–542. Our findings also suggest that antiproliferative activity of RNF219 is at least partially mediated by ...
Shou Soeda, Melissa Montrose, Akinori Takahashi, Risa Ishida, Sandrine Burriel, Nao Ohmine, Tohru Natsume, Shungo Adachi, Minsoo Kim, Tadashi Yamamoto   +9 more
wiley   +1 more source

Abstract OR-15: Structural and Functional Studies of the Staphylococcus aureus Ribosome Hibernation [PDF]

International Journal of Biomedicine, 2019
Background: In bacteria, diminishing of protein synthesis is often accompanied with the formation of ribosomal dimers (or disomes). This process might be particularly important for pathogenic bacteria whose successful survival is a key factor for ...
Konstantin Usachev, Iskander Khusainov, Bulat Fatkhullin, Shamil Validov, Marat Yusupov   +4 more
doaj   +1 more source

Compound Heterozygous MRPS14 Variants Associated With Leigh Syndrome

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT MRPS14 (uS14m) is a nuclear‐encoded ribosomal protein important for mitochondria‐specific translation. To date, only a single individual with a recessive MRPS14‐related disorder (also known as COXPD38) has been reported. We report an additional subject possessing novel compound heterozygous MRPS14 variants (p.Asp37Asn, p.Asn60Asp). The subject
Maria Gabriela Otero, Christina Freeman, Ruchi Shah, Renkui Bai, Hong Cui, Marian Castro, Zachary Myers, Eric Choy, Derek Chan, Molly Easter, Sophia Y. Zhao, Madeline Babros, Ruchi Garg, Matthew Deardorff, Franklin Moser, Tyler Mark Pierson   +15 more
wiley   +1 more source

Single nucleotide polymorphisms in the CDH18 gene affect growth traits in Hu sheep

Animal Research and One Health, EarlyView., 2023
Abstract Growth traits are critical economic traits in sheep. Genetic polymorphism has a great influence on the improvement of sheep traits. The aim of this study was to analyze the effect of cadherin 18 (CDH18) gene polymorphisms on growth traits in Hu sheep.
Tianyi Liu, Yazhen Bi, Jingjing Bao, Mingyu Shang, Wenping Hu, Li Zhang   +5 more
wiley   +1 more source

Current and Future Experimental Strategies for Structural Analysis of Trichothecene Mycotoxins—A Prospectus

Toxins, 2011
Fungal toxins, such as those produced by members of the order Hypocreales, have widespread effects on cereal crops, resulting in yield losses and the potential for severe disease and mortality in humans and livestock.
Barbara A. Blackwell, François Eudes, Paul Hazendonk, Nora A. Foroud, Roxanne A. Shank   +4 more
doaj   +1 more source