Results 51 to 60 of about 254,623 (219)

Cotranslational folding of proteins on the ribosome.

, 2020
Many proteins in the cell fold cotranslationally within the restricted space of the polypeptide exit tunnel or at the surface of the ribosome. A growing body of evidence suggests that the ribosome can alter the folding trajectory in many different ways ...
Liutkute, M., Rodnina, M., Samatova, E.
core   +1 more source

Application of fluorescence correlation spectroscopy to investigate the dynamics of a ribosome-associated trigger factor in Escherichia coli

Frontiers in Molecular Biosciences, 2022
Co-translational protein folding is one of the central topics in molecular biology. In Escherichia coli, trigger factor (TF) is a primary chaperone that facilitates co-translational folding by directly interacting with nascent polypeptide chains on ...
Tatsuya Niwa, Tatsuya Niwa, Koki Nakazawa, Kensuke Hoshi, Hisashi Tadakuma, Koichi Ito, Hideki Taguchi, Hideki Taguchi   +7 more
doaj   +1 more source

Modelling the effect of ribosome mobility on the rate of protein synthesis [PDF]

Eur. Phys. J. E 44, 19 (2021), 2020
Translation is one of the main steps in the synthesis of proteins. It consists of ribosomes that translate sequences of nucleotides encoded on mRNA into polypeptide sequences of amino acids. Ribosomes bound to mRNA move unidirectionally, while unbound ribosomes diffuse in the cytoplasm.
arxiv   +1 more source

Homeostatic Roles of the Proteostasis Network in Dendrites

Frontiers in Cellular Neuroscience, 2020
Cellular protein homeostasis, or proteostasis, is indispensable to the survival and function of all cells. Distinct from other cell types, neurons are long-lived, exhibiting architecturally complex and diverse multipolar projection morphologies that can ...
Erin N. Lottes, Daniel N. Cox
doaj   +1 more source

Active role of elongation factor G in maintaining the mRNA reading frame during translation. [PDF]

, 2019
During translation, the ribosome moves along the mRNA one codon at a time with the help of elongation factor G (EF-G). Spontaneous changes in the translational reading frame are extremely rare, yet how the precise triplet-wise step is maintained is not ...
Belardinelli, R., Bock, L., Grubmüller, H., Peng, B., Peske, F., Rodnina, M.   +5 more
core   +2 more sources

Traffic of interacting ribosomes: effects of single-machine mechano-chemistry on protein synthesis [PDF]

Physical Review E 75, 021902 (2007), 2006
Many ribosomes simultaneously move on the same messenger RNA (mRNA), each separately synthesizing the protein coded by the mRNA. Earlier models of ribosome traffic represent each ribosome by a ``self-propelled particle'' and capture the dynamics by an extension of the totally asymmetric simple exclusion process (TASEP).
arxiv   +2 more sources

How Ricin Damages the Ribosome

Toxins, 2019
Ricin belongs to the group of ribosome-inactivating proteins (RIPs), i.e., toxins that have evolved to provide particular species with an advantage over other competitors in nature.
Przemysław Grela, Monika Szajwaj, Patrycja Horbowicz-Drożdżal, Marek Tchórzewski   +3 more
doaj   +1 more source

Protein folding on the ribosome studied using NMR spectroscopy [PDF]

, 2013
NMR spectroscopy is a powerful tool for the investigation of protein folding and misfolding, providing a characterization of molecular structure, dynamics and exchange processes, across a very wide range of timescales and with near atomic resolution.
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core   +1 more source

Viral and cellular translation during SARS‐CoV‐2 infection

FEBS Open Bio, 2022
SARS‐CoV‐2 is a betacoronavirus that emerged in China in December 2019 and which is the causative agent of the Covid‐19 pandemic. This enveloped virus contains a large positive‐sense single‐stranded RNA genome.
Gilbert Eriani, Franck Martin
doaj   +1 more source

Nascent Ribosomes [PDF]

Cell, 2001
The conversion of a ribosomal RNA transcript to a cytoplasmic ribosome requires hundreds of accessory RNA and protein factors. Two papers published recently in Molecular Cell provide first looks at the association of these processing factors with the intermediates in ribosome synthesis (Harnpicharnchai et al., 2001; Bassler et al., 2001).
openaire   +2 more sources