Results 91 to 100 of about 44,034 (296)
Virology Journal, 2010 Background Hepatitis delta virus (HDV) ribozyme is an attractive molecular tool that can specifically recognize and catalyze the self-cleavage of the viral RNA phosphodiester backbone.
Chen Long-Hua +4 more
doaj +1 more source
Genome Biology, 2023 Background CRISPR-Cas13 is a newly emerging RNA knockdown technology that is comparable to RNAi. Among all members of Cas13, CasRx degrades RNA in human cells with high precision and effectiveness.
Yonghao Zhan +4 more
doaj +1 more source
Microbiology and Immunology, Volume 70, Issue 2, Page 80-90, February 2026.ABSTRACT Orthobornaviruses express X and the phosphoprotein (P) from a bicistronic X/P mRNA, and these proteins regulate polymerase activity. In mammalian orthobornaviruses, the 5′ untranslated region (5′ UTR) of the X/P mRNA controls the translational balance between X and P and thereby promotes efficient replication.
Meng‐Chi Wu +7 more
wiley +1 more source
BMC Research Notes, 2008 Background Hepatitis delta virus (HDV) is a satellite virus of hepatitis B. During viral replication the 1700-nucleotide-long genomic RNA and its complement, the antigenomic RNA, undergo self-cleavage catalyzed by internal ribozyme motifs that are ...
Dobrynina Nadezhda +4 more
doaj +1 more source
Hammerhead ribozyme kinetics [PDF]
RNA, 1998 The hammerhead ribozyme is a small RNA motif that self cleaves at a specific phosphodiester bond to produce 2′,3′ cyclic phosphate and 5′ hydroxyl termini (Hutchins et al., 1986; Forster & Symons, 1987a). The secondary structure of the hammerhead consists of three helices of arbitrary sequence and length (designated I, II, and III) that intersect at 15
T K, Stage-Zimmermann, O C, Uhlenbeck
openaire +2 more sources
A structural analysis of
BMC Bioinformatics, 2007 Background Ribozymes are small catalytic RNAs that possess the dual functions of sequence-specific RNA recognition and site-specific cleavage. Trans-cleaving ribozymes can inhibit translation of genes at the messenger RNA (mRNA) level in both eukaryotic ...
Schneider Erasmus +5 more
doaj +1 more source
The origins and physical roots of life’s dual – metabolic and genetic – nature [PDF]
, 2017 This review paper aims at a better understanding of the origin and physical foundation of life’s dual – metabolic and genetic – nature. First, I give a concise ‘top-down’ survey of the origin of life, i.e., backwards in time from extant DNA/RNA/protein ...
De Tiège, Alexis
core +2 more sources
Cryo-EM structures of full-length Tetrahymena ribozyme at 3.1 Å resolution
Nature, 2021 Z. Su +10 more
semanticscholar +1 more source
Crystal Structure of the VS ribozyme
Nature Chemical Biology, 2015 Varkud Satellite (VS) ribozyme mediates rolling circle replication of a plasmid found in the Neurospora mitochondria. We report crystal structures of this ribozyme at 3.1Å resolution, revealing an intertwined dimer formed by an exchange of substrate ...
N. Suslov +6 more
semanticscholar +1 more source
Advanced Functional Materials, Volume 36, Issue 5, 15 January 2026.Many known diseases arise from dysregulated gene expression, and differentially expressed genes can serve as biomarkers to distinguish diseased cells from healthy tissues. In this study, reconfigurable nucleic acid nanoparticles (recNANPs) are introduced that can detect overexpressed cancer biomarkers and subsequently release RNAi inducers to silence ...
Yelixza I. Avila +7 more
wiley +1 more source