Results 11 to 20 of about 43,119 (293)
The Hammerhead Ribozyme: A Long History for a Short RNA
Molecules, 2017 Small nucleolytic ribozymes are a family of naturally occurring RNA motifs that catalyse a self-transesterification reaction in a highly sequence-specific manner.
Marcos de la Peña +2 more
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Structure-based insights into self-cleavage by a four-way junctional twister-sister ribozyme
Nature Communications, 2017 Twister-sister is a self-cleaving ribozyme. Here, the authors report the 2.0 Å crystal structure of the four-way junctional twister-sister ribozyme in the pre-catalytic state and discuss mechanistic implications based on their mutagenesis experiments and
Luqian Zheng +7 more
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Ribozyme-catalysed RNA synthesis using triplet building blocks
eLife, 2018 RNA-catalyzed RNA replication is widely believed to have supported a primordial biology. However, RNA catalysis is dependent upon RNA folding, and this yields structures that can block replication of such RNAs.
James Attwater +4 more
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Inducible knockdown of Plasmodium gene expression using the glmS ribozyme.
PLoS ONE, 2013 Conventional reverse genetic approaches for study of Plasmodium malaria parasite gene function are limited, or not applicable. Hence, new inducible systems are needed. Here we describe a method to control P.
Parichat Prommana +7 more
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Nature Chemistry, 2022 It has long been proposed that phase-separated compartments can provide a basis for the formation of cellular precursors in prebiotic environments.
Juan M. Iglesias-Artola +6 more
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Structure and mechanism of a methyltransferase ribozyme
Nature Chemical Biology, 2022 Known ribozymes in contemporary biology perform a limited range of chemical catalysis, but in vitro selection has generated species that catalyze a broader range of chemistry; yet, there have been few structural and mechanistic studies of selected ...
J. Deng +8 more
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A cell-based ribozyme reporter system employing a chromosomally-integrated 5′ exonuclease gene
BMC Molecular and Cell Biology, 2021 Background Bioinformatic genome surveys indicate that self-cleaving ribonucleic acids (ribozymes) appear to be widespread among all domains of life, although the functions of only a small number have been validated by biochemical methods.
Aiyada Aroonsri +4 more
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Effective inhibition of human immunodeficiency virus 1 replication by engineered RNase P ribozyme. [PDF]
PLoS ONE, 2012 Using an in vitro selection procedure, we have previously isolated RNase P ribozyme variants that efficiently cleave an mRNA sequence in vitro. In this study, a variant was used to target the HIV RNA sequence in the tat region.
Wenbo Zeng +7 more
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Catalytic RNA Oligomers Formed by Co-Oligomerization of a Pair of Bimolecular RNase P Ribozymes
Molecules, 2022 Naturally occurring ribozymes with a modular architecture are promising platforms for construction of RNA nanostructures because modular redesign enables their oligomerization.
Mst. Ayesha Siddika +7 more
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An RNA polymerase ribozyme that synthesizes its own ancestor
Proceedings of the National Academy of Sciences of the United States of America, 2020 Significance Life depends on the propagation of heritable information across successive generations. An RNA polymerase ribozyme was obtained by in vitro evolution that has an unprecedented level of activity in copying complex RNA templates.
Katrina F. Tjhung +3 more
semanticscholar +1 more source