Results 31 to 40 of about 43,119 (293)

Selection for Replicases in Protocells [PDF]

, 2013
PMCID: PMC3649988This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are ...
A Kun, A Traulsen, A Wochner, AI Rushdi, AJ Dzieciol, AJ Markvoort, DE Kim, DW Deamer, E Szathmary, F Mavelli, G Yuen, Ginestra Bianconi, GU Yuen, GU Yuen, H Naraoka, HS Zaher, I Scheuring, IA Chen, IA Chen, Irene A. Chen, J Dworkin, JA Doudna, JF Fontanari, JG Lawless, JW Szostak, JW Szostak, K Kurihara, K Leu, KD James, Kun Zhao, M Eigen, M Eigen, M Leaver, M Nowak, M Wu, MA Nowak, MA Nowak, MA Nowak, Martin A. Nowak, Michael Doebeli, N Paul, N Takeuchi, N Vaidya, P Hogeweg, P Hogeweg, P Stano, P Szabo, P Walde, PG Higgs, RC Lewontin, RM Turk, SF Zenisek, SS Jain, SS Mansy, TA Lincoln, TF Zhu, TF Zhu, TM McCollom, UF Müller, V Vasas, WK Johnston, WV Allen   +61 more
core   +10 more sources

Engineered RNase P Ribozymes Effectively Inhibit Human Cytomegalovirus Gene Expression and Replication

Viruses, 2014
RNase P ribozyme can be engineered to be a sequence-specific gene-targeting agent with promising application in both basic research and clinical settings.
Zhu Yang, Gia-Phong Vu, Hua Qian, Yuan-Chuan Chen, Yu Wang, Michael Reeves, Ke Zen, Fenyong Liu   +7 more
doaj   +1 more source

Ribo-On and Ribo-Off tools using a self-cleaving ribozyme allow manipulation of endogenous gene expression in C. elegans

Communications Biology, 2023
Investigating gene function relies on the efficient manipulation of endogenous gene expression. Currently, a limited number of tools are available to robustly manipulate endogenous gene expression between “on” and “off” states. In this study, we insert a
Jie Fang, Jie Wang, Yuzhi Wang, Xiaofan Liu, Baohui Chen, Wei Zou   +5 more
doaj   +1 more source

The Origin of Life: Models and Data. [PDF]

, 2017
A general framework for conventional models of the origin of life (OOL) is the specification of a 'privileged function.' A privileged function is an extant biological function that is excised from its biological context, elevated in importance over other
Lanier, Kathryn A, Williams, Loren Dean
core   +1 more source

Induction of ribozyme activity by anti-ribozyme oligonucleotides [PDF]

Nucleic Acids Symposium Series, 1999
A new type of hammerhead ribozyme, with cleavage activity enhanced by oligonucleotides, was constructed. Stem II of the ribozyme was substituted with a non complementary loop (loop II). The modified ribozyme exhibited negligible cleavage of a target RNA; however, it was converted to an active molecule in the presence of oligonucleotides which were ...
Nobuhiro Kazama, Eiko Ohtsuka, Yasuo Komatsu, Shigeko Yamashita   +3 more
openaire   +3 more sources

The prebiotic evolutionary advantage of transferring genetic information from RNA to DNA. [PDF]

, 2011
In the early 'RNA world' stage of life, RNA stored genetic information and catalyzed chemical reactions. However, the RNA world eventually gave rise to the DNA-RNA-protein world, and this transition included the 'genetic takeover' of information storage ...
Chen, Irene A, Gerland, Ulrich, Leu, Kevin, Obermayer, Benedikt, Rajamani, Sudha   +4 more
core   +4 more sources

Ribozyme Therapeutics [PDF]

Journal of Investigative Dermatology Symposium Proceedings, 2002
Since their initial discovery, ribozymes have shown great promise not just as a tool in the manipulation of gene expression, but also as a novel therapeutic agent. This review discusses the promises and pitfalls of ribozyme technology, with a special emphasis on cancer-related applications, though relevance to skin disease will also be discussed.
openaire   +2 more sources

Development of a Functionally Minimized Mutant of the R3C Ligase Ribozyme Offers Insight into the Plausibility of the RNA World Hypothesis

Biology, 2014
The R3C ligase ribozyme is an artificial ligase ribozyme produced by modification of the ribozyme that lacks cytidine. Here, we attempted to modify the original R3C ribozyme (73 nucleotides) by reducing the number of nucleotides while maintaining the ...
Eri Kurihara, Sayuri Uchida, Takuya Umehara, Koji Tamura   +3 more
doaj   +1 more source

RNA interference approaches for treatment of HIV-1 infection. [PDF]

, 2015
HIV/AIDS is a chronic and debilitating disease that cannot be cured with current antiretroviral drugs. While combinatorial antiretroviral therapy (cART) can potently suppress HIV-1 replication and delay the onset of AIDS, viral mutagenesis often leads to
Bobbin, Maggie L, Burnett, John C, Rossi, John J   +2 more
core   +1 more source

Inhibition of human cytomegalovirus immediate early gene expression and growth by a novel RNase P ribozyme variant. [PDF]

PLoS ONE, 2017
We have previously engineered new RNase P-based ribozyme variants with improved in vitro catalytic activity. In this study, we employed a novel engineered variant to target a shared mRNA region of human cytomegalovirus (HCMV) immediate early proteins 1 ...
Xu Sun, Weijie Chen, Lingling He, Jingxue Sheng, Yujun Liu, Gia-Phong Vu, Zhu Yang, Wei Li, Phong Trang, Yu Wang, Rong Hai, Hua Zhu, Sangwei Lu, Fenyong Liu   +13 more
doaj   +1 more source