Results 41 to 50 of about 28,198 (287)
NLP Meets RNA: Unsupervised Embedding Learning for Ribozymes with Word2Vec [PDF]
arXiv, 2023 Ribozymes, RNA molecules with distinct 3D structures and catalytic activity, have widespread applications in synthetic biology and therapeutics. However, relatively little research has focused on leveraging deep learning to enhance our understanding of ribozymes.
arxiv
Inhibition of telomerase activity by HDV ribozyme in cancers
Journal of Experimental & Clinical Cancer Research, 2011 Background Telomerase plays an important role in cell proliferation and carcinogenesis and is believed to be a good target for anti-cancer drugs. Elimination of template function of telomerase RNA may repress the telomerase activity.
Gao Yanjing +4 more
doaj +1 more source
Ligand‐dependent ribozymes [PDF]
WIREs RNA, 2016 The discovery of catalytic RNA (ribozymes) more than 30 years ago significantly widened the horizon of RNA‐based functions in natural systems. Similarly to the activity of protein enzymes that are often modulated by the presence of an interaction partner, some examples of naturally occurring ribozymes are influenced by ligands that can either act as ...
Felletti, Michele, Hartig, Jörg S.
openaire +3 more sources
Remote Control of Eukaryotic Gene Expression by a Modular Ultrasound‐Responsive RNA Toolkit
Angewandte Chemie, EarlyView.A modular RNA‐based sonogenetic toolkit enables remote control of gene expression in eukaryotes by releasing small molecule modulators from ultrasound‐responsive carriers. These modulators activate engineered mRNA elements such as riboswitches, leading to tunable protein expression.
Fahimeh Charbgoo +7 more
wiley +2 more sources
The Kiss Switch Brings Inactive R3C Ligase Ribozyme Back to Life
Biology, 2018 R3C ligase ribozyme catalyzes the nucleophilic attack by a 3′-hydroxyl on a 5′-α-phosphorus of triphosphates to form a 3′-5′-phosphodiester bond. In the present study, although the truncation of R3C ribozyme was accompanied by a large reduction in ...
Kana Tanizawa +4 more
doaj +1 more source
Polyanion-Assisted Ribozyme Catalysis Inside Complex Coacervates.
ACS Chemical Biology, 2019 Owing to their ability to encapsulate biomolecules, complex coacervates formed by associative phase separation of oppositely charged polyelectrolytes have been postulated as prebiotic nonmembranous compartments (NMCs).
Raghav R. Poudyal +2 more
semanticscholar +1 more source
Ribozyme‐Catalyzed Site‐Specific Labeling of RNA Using O6‐alkylguanine SNAP‐Tag Substrates
Angewandte Chemie, EarlyView.SNAPR is a ribozyme that repurposes O6‐benzylguanine SNAP‐tag substrates for site‐specific labeling of RNA with bioorthogonal alkyne and azide functional groups, fluorophores or photocrosslinkers. The N1A‐alkylated RNA products were converted to N6A‐modified RNA by Dimroth rearrangement.
Manisha B. Walunj +3 more
wiley +2 more sources
Ribozyme activity modulates the physical properties of RNA–peptide coacervates
eLife, 2023 Condensed coacervate phases are now understood to be important features of modern cell biology, as well as valuable protocellular models in origin-of-life studies and synthetic biology.
Kristian Kyle Le Vay +4 more
doaj +1 more source
Nature Communications, 2019 The nematode Caenorhabditis elegans represents an important research model. Convenient methods for conditional induction of gene expression in this organism are not available.
Lena A. Wurmthaler +4 more
semanticscholar +1 more source
Mechanical unfolding of RNA: From hairpins to structures with internal multiloops [PDF]
Biophys. J. vol 92 (2007) 731-743, 2006 Mechanical unfolding of RNA structures, ranging from hairpins to ribozymes, using laser optical tweezer (LOT) experiments have begun to reveal the features of the energy landscape that cannot be easily explored using conventional experiments. Upon application of constant force ($f$), RNA hairpins undergo cooperative transitions from folded to unfolded ...
arxiv +1 more source