Results 51 to 60 of about 43,119 (293)
Ribozyme activity modulates the physical properties of RNA–peptide coacervates
eLife, 2023 Condensed coacervate phases are now understood to be important features of modern cell biology, as well as valuable protocellular models in origin-of-life studies and synthetic biology.
Kristian Kyle Le Vay +4 more
doaj +1 more source
Journal of the American Chemical Society, 2019 Molecular evolution can be conceptualized as a walk over a “fitness landscape”, or the function of fitness (e.g., catalytic activity) over the space of all possible sequences.
A. Pressman +7 more
semanticscholar +1 more source
Equilibrium properties and force-driven unfolding pathways of RNA molecules
, 2009 The mechanical unfolding of a simple RNA hairpin and of a 236--bases portion of the Tetrahymena thermophila ribozyme is studied by means of an Ising--like model.
A. Imparato +3 more
core +1 more source
A reverse transcriptase ribozyme [PDF]
eLife, 2017 A highly evolved RNA polymerase ribozyme was found to also be capable of functioning as a reverse transcriptase, an activity that has never been demonstrated before for RNA. This activity is thought to have been crucial for the transition from RNA to DNA genomes during the early history of life on Earth, when it similarly could have arisen as a ...
Biswajit Samanta, Gerald F Joyce
openaire +3 more sources
Biochemical prevention and treatment of viral infections – A new paradigm in medicine for infectious diseases [PDF]
, 2004 For two centuries, vaccination has been the dominating approach to develop prophylaxis against viral infections through immunological prevention. However, vaccines are not always possible to make, are ineffective for many viral infections, and also carry
Fang, Fang, Le Calvez, Hervé, Yu, Mang
core +3 more sources
Design of Mammalian ON-Riboswitches Based on Tandemly Fused Aptamer and Ribozyme.
ACS Synthetic Biology, 2019 Self-cleaving ribozymes engineered to be activated or inhibited by a small molecule binding to an RNA aptamer inserted within a ribozyme (aptazymes) have proven to be useful for controlling gene expression in living cells. In mammalian cells, an aptazyme
Kamila Mustafina +2 more
semanticscholar +1 more source
Pistol ribozyme adopts a pseudoknot fold facilitating site-specific in-line cleavage
Nature Chemical Biology, 2016 The field of small self-cleaving nucleolytic ribozymes has been invigorated by the recent discovery of the twister, twister-sister, pistol and hatchet ribozymes.
A. Ren +7 more
semanticscholar +1 more source
Ribocentre: a database of ribozymes
Nucleic Acids Research, 2022 Abstract Ribozymes are excellent systems in which to study ‘sequence - structure - function’ relationships in RNA molecules. Understanding these relationships may greatly help structural modeling and design of functional RNA structures and some functional structural modules could be repurposed in molecular design. At present, there is no
Jie Deng +12 more
openaire +3 more sources
Horizontal transfer between loose compartments stabilizes replication of fragmented ribozymes
, 2019 The emergence of replicases that can replicate themselves is a central issue in the origin of life. Recent experiments suggest that such replicases can be realized if an RNA polymerase ribozyme is divided into fragments short enough to be replicable by ...
Kamimura, Atsushi +3 more
core +2 more sources
Journal of Integrative Plant Biology, 2014 CRISPR/Cas9 uses a guide RNA (gRNA) molecule to execute sequence-specific DNA cleavage and it has been widely used for genome editing in many organisms. Modifications at either end of the gRNAs often render Cas9/gRNA inactive.
Yangbin Gao, Yunde Zhao
semanticscholar +1 more source