Results 51 to 60 of about 28,198 (287)
Arginine cofactors on the polymerase ribozyme. [PDF]
PLoS ONE, 2011 The RNA world hypothesis states that the early evolution of life went through a stage in which RNA served both as genome and as catalyst. The central catalyst in an RNA world organism would have been a ribozyme that catalyzed RNA polymerization to ...
Chengguo Yao +4 more
doaj +1 more source
A reverse transcriptase ribozyme [PDF]
eLife, 2017 A highly evolved RNA polymerase ribozyme was found to also be capable of functioning as a reverse transcriptase, an activity that has never been demonstrated before for RNA. This activity is thought to have been crucial for the transition from RNA to DNA genomes during the early history of life on Earth, when it similarly could have arisen as a ...
Biswajit Samanta, Gerald F Joyce
openaire +3 more sources
Journal of the American Chemical Society, 2019 Molecular evolution can be conceptualized as a walk over a “fitness landscape”, or the function of fitness (e.g., catalytic activity) over the space of all possible sequences.
A. Pressman +7 more
semanticscholar +1 more source
Information theory in molecular biology [PDF]
Physics of Life Reviews 1 (2004) 3-22, 2004 This article introduces the physics of information in the context of molecular biology and genomics. Entropy and information, the two central concepts of Shannon's theory of information and communication, are often confused with each other but play transparent roles when applied to statistical ensembles (i.e., identically prepared sets) of symbolic ...
arxiv +1 more source
Ribocentre: a database of ribozymes
Nucleic Acids Research, 2022 Abstract Ribozymes are excellent systems in which to study ‘sequence - structure - function’ relationships in RNA molecules. Understanding these relationships may greatly help structural modeling and design of functional RNA structures and some functional structural modules could be repurposed in molecular design. At present, there is no
Jie Deng +12 more
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Pistol ribozyme adopts a pseudoknot fold facilitating site-specific in-line cleavage
Nature Chemical Biology, 2016 The field of small self-cleaving nucleolytic ribozymes has been invigorated by the recent discovery of the twister, twister-sister, pistol and hatchet ribozymes.
A. Ren +7 more
semanticscholar +1 more source
The structure of a nucleolytic ribozyme that employs a catalytic metal ion
Nature Chemical Biology, 2017 The TS ribozyme (originally called twister-sister) is a nucleolytic catalytic RNA. We present a crystal structure of the ribozyme in a pre-reactive conformation. Two co-axial helical stacks are organized by a three-way junction and two tertiary contacts.
Yanjun Liu, T. J. Wilson, D. Lilley
semanticscholar +1 more source
Ion Condensation onto Ribozyme is Site-Specific and Fold-Dependent [PDF]
, 2019 The highly charged RNA molecules, with each phosphate carrying a single negative charge, cannot fold into well-defined architectures with tertiary interactions, in the absence of ions. For ribozymes, divalent cations are known to be more efficient than monovalent ions in driving them to a compact state although Mg$^{2+}$ ions are needed for catalytic ...
arxiv +1 more source
Watching ion-driven kinetics of ribozyme folding and misfolding caused by energetic and topological frustration one molecule at a time [PDF]
arXiv, 2023 Folding of ribozymes into well-defined tertiary structures usually requires divalent cations. How Mg$^{2+}$ ions direct the folding kinetics has been a long-standing unsolved problem because experiments cannot detect the positions and dynamics of ions.
arxiv
Horizontal transfer between loose compartments stabilizes replication of fragmented ribozymes [PDF]
, 2019 The emergence of replicases that can replicate themselves is a central issue in the origin of life. Recent experiments suggest that such replicases can be realized if an RNA polymerase ribozyme is divided into fragments short enough to be replicable by the ribozyme and if these fragments self-assemble into a functional ribozyme.
arxiv +1 more source