Results 51 to 60 of about 10,421 (212)

Flotillins in membrane trafficking and physiopathology

Biology of the Cell, Volume 117, Issue 1, January 2025.
Flotillin 1 and 2 scaffold sphingolipid‐rich membrane microdomains involved in endocytosis and endolysosome maturation through the generation of sphingosine 1‐phosphate (S1P) by sphingosine kinase 2 (SphK2). Hence they deregulate protein cargo trafficking and influence cell signaling and cellular invasion.
Stéphane Bodin, Hadeer Elhabashy, Ewan Macdonald, Dominic Winter, Cécile Gauthier‐Rouvière   +4 more
wiley   +1 more source

Neutralising antibodies against ricin toxin. [PDF]

PLoS ONE, 2011
The Centers for Disease Control and Prevention have listed the potential bioweapon ricin as a Category B Agent. Ricin is a so-called A/B toxin produced by plants and is one of the deadliest molecules known. It is easy to prepare and no curative treatment
Julie Prigent, Laetitia Panigai, Patricia Lamourette, Didier Sauvaire, Karine Devilliers, Marc Plaisance, Hervé Volland, Christophe Créminon, Stéphanie Simon   +8 more
doaj   +1 more source

Elucidation of the late steps in the glycan‐dependent ERAD of soluble misfolded glycoproteins

The Plant Journal, Volume 121, Issue 1, January 2025.
Significance Statement ER‐associated degradation (ERAD) represents an important cellular pathway that ensures protein degradation and restores protein homeostasis. In this study, we employed a retrotranslocation assay in conjunction with a biochemical analysis to elucidate the role of distinct ER and cytosolic proteins during ERAD.
Jennifer Schoberer, Ulrike Vavra, Yun‐Ji Shin, Clemens Grünwald‐Gruber, Richard Strasser   +4 more
wiley   +1 more source

Recommended Immunological Assays to Screen for Ricin-Containing Samples

Toxins, 2015
Ricin, a toxin from the plant Ricinus communis, is one of the most toxic biological agents known. Due to its availability, toxicity, ease of production and absence of curative treatments, ricin has been classified by the Centers for Disease Control and ...
Stéphanie Simon, Sylvia Worbs, Marc-André Avondet, Dobryan M. Tracz, Julie Dano, Lisa Schmidt, Hervé Volland, Brigitte G. Dorner, Cindi R. Corbett   +8 more
doaj   +1 more source

Ricin Poisoning [PDF]

JAMA, 2005
The recent discoveries of ricin, a deadly biologic toxin, at a South Carolina postal facility, a White House mail facility, and a US senator's office has raised concerns among public health officials, physicians, and citizens. Ricin is one of the most potent and lethal substances known, particularly when inhaled.
John D. Osterloh, Jennifer Audi, Joshua G. Schier, Manish M. Patel, Martin G. Belson   +4 more
openaire   +2 more sources

Broad‐Spectrum Engineered Multivalent Nanobodies Against SARS‐CoV‐1/2

Advanced Science, Volume 11, Issue 45, December 4, 2024.
This study presents the design and development of multivalent nanobodies targeting conserved epitopes of SARS‐CoV‐1 and SARS‐CoV‐2. The trivalent nanobody B11‐E8‐F3 exhibits broad‐spectrum neutralization against SARS‐CoV‐1 and multiple SARS‐CoV‐2 variants, including Omicron sublineages, and demonstrates significant preventive and therapeutic efficacy ...
Zhihong Wang, Zhuangzhuang Shi, Xiaochen Liao, Guiqi Quan, Hui Dong, Pinnan Zhao, Yangyihua Zhou, Ning Shi, Jie Wang, Yahui Wu, Chunxia Qiao, Xin ying Li, Ran Zhang, Zekun Wang, Tiecheng Wang, Xiang Gao, Jiannan Feng, Longlong Luo   +17 more
wiley   +1 more source

Recommended Mass Spectrometry-Based Strategies to Identify Ricin-Containing Samples

Toxins, 2015
Ricin is a protein toxin produced by the castor bean plant (Ricinus communis) together with a related protein known as R. communis agglutinin (RCA120). Mass spectrometric (MS) assays have the capacity to unambiguously identify ricin and to detect ricin’s
Suzanne R. Kalb, David M. Schieltz, François Becher, Crister Astot, Sten-Åke Fredriksson, John R. Barr   +5 more
doaj   +1 more source

Biotechnological Interventions for the Production of Subunit Vaccines Against Group A Rotavirus

Cell Biochemistry and Function, Volume 42, Issue 8, December 2024.
ABSTRACT Group A rotavirus (RVA) is a major cause of severe gastroenteritis in infants and young children globally, despite the availability of live‐attenuated vaccines. Challenges such as limited efficacy in low‐income regions, safety concerns for immunocompromised individuals, and cold‐chain dependency necessitate alternative vaccine strategies ...
Mukta Prajapati, Pooja Malik, Astha Sinha, Honey Yadav, Yachna K. Jaiwal, Yogesh K. Ahlawat, Darshna Chaudhary, Ranjana Jaiwal, Nisha Sharma, Pawan K. Jaiwal, Vijay K. Chattu   +10 more
wiley   +1 more source

A Novel Zak Knockout Mouse with a Defective Ribotoxic Stress Response

Toxins, 2016
Ricin activates the proinflammatory ribotoxic stress response through the mitogen activated protein 3 kinase (MAP3K) ZAK, resulting in activation of mitogen activated protein kinases (MAPKs) p38 and JNK1/2.
Dakshina M. Jandhyala, John Wong, Nicholas J. Mantis, Bruce E. Magun, John M. Leong, Cheleste M. Thorpe   +5 more
doaj   +1 more source

Review article: The nature of terror medicine

Emergency Medicine Australasia, Volume 36, Issue 6, Page 815-822, December 2024.
Unique and Severe Injuries (Explosion Icon). Rapid Triage and Scene Safety (Clock Icon). Psychological Effects (Brain/Heart Icon). Broader Public Health Implications (Globe/Community Icon). Ethical and Legal Challenges (Scales/Legal Document Icon). This graphical abstract connects the central theme of the topic to the key points.
George Braitberg
wiley   +1 more source