Results 61 to 70 of about 10,421 (212)
Why Can't We Predict RNA Structure At Atomic Resolution? [PDF]
arXiv, 2011 No existing algorithm can start with arbitrary RNA sequences and return the precise, three-dimensional structures that ensures their biological function. This chapter outlines current algorithms for automated RNA structure prediction (including our own FARNA-FARFAR), highlights their successes, and dissects their limitations, using a tetraloop and the ...
arxiv
Toxins, 2017 Ricin is a type II ribosome-inactivating toxin that catalytically inactivates ribosomes ultimately leading to cell death. The toxicity of ricin along with the prevalence of castor beans (its natural source) has led to its increased notoriety and ...
Sarah J. C. Whitfield +8 more
doaj +1 more source
The receptor-toxin-antibody interaction: Mathematical model and numerical simulation [PDF]
arXiv, 2012 A reaction-diffusion model of receptor-toxin-antibody (RTA) interaction is studied numerically. The protective properties of an antibody against a given toxin are evaluated for a spherical cell placed into a toxin-antibody solution. The selection of parameters for numerical simulation approximately corresponds to the practically relevant values ...
arxiv
Pairing Alpaca and Llama-Derived Single Domain Antibodies to Enhance Immunoassays for Ricin
Antibodies, 2017 Previously, our group isolated and evaluated anti-ricin single domain antibodies (sdAbs) derived from llamas, engineered them to further increase their thermal stability, and utilized them for the development of sensitive immunoassays. In work focused on
Kendrick B. Turner +6 more
doaj +1 more source
Toxins, 2020 Ricin, produced from the castor beans of Ricinus communis, is a cytotoxin that exerts its action by inactivating ribosomes and causing cell death. Accidental (e.g., ingestion of castor beans) and/or intentional (e.g., suicide) exposure to ricin through ...
Sarah J. Whitfield +6 more
doaj +1 more source
Single domain antibody: Development and application in biotechnology and biopharma
Immunological Reviews, Volume 328, Issue 1, Page 98-112, November 2024.Summary Heavy‐chain antibodies (HCAbs) are a unique type of antibodies devoid of light chains, and comprised of two heavy chains‐only that recognize their cognate antigen by virtue of a single variable domain also referred to as VHH, single domain antibody (sdAb), or nanobody (Nb).
Ting Yu +4 more
wiley +1 more source
Toxins, 2017 Ricin, a highly toxic plant-derived toxin, is considered a potential weapon in biowarfare and bioterrorism due to its pronounced toxicity, high availability, and ease of preparation.
Yoav Gal +6 more
doaj +1 more source
Antibodies in breast milk: Pro‐bodies designed for healthy newborn development
Immunological Reviews, Volume 328, Issue 1, Page 192-204, November 2024.Summary This manuscript sheds light on the impact of maternal breast milk antibodies on infant health. Milk antibodies prepare and protect the newborn against environmental exposure, guide and regulate the offspring's immune system, and promote transgenerational adaptation of the immune system to its environment.
Valerie Verhasselt +3 more
wiley +1 more source
Understanding Ricin from a Defensive Viewpoint
Toxins, 2011 The toxin ricin has long been understood to have potential for criminal activity and there has been concern that it might be used as a mass-scale weapon on a military basis for at least two decades.
Gareth D. Griffiths
doaj +1 more source
Mitochondrial ribosome biogenesis and redox sensing
FEBS Open Bio, Volume 14, Issue 10, Page 1640-1655, October 2024.Mitoribosome assembly coordinates rRNAs folding and modification with riboprotein incorporation assisted by assembly factors like RNA helicases, GTPases, and RNA‐modifying enzymes. Biochemical and structural analyses have enhanced the pathway resolution.
Michele Brischigliaro +3 more
wiley +1 more source