Antibody-Mediated Inhibition of Ricin Toxin Retrograde Transport
mBio, 2014 Ricin is a member of the ubiquitous family of plant and bacterial AB toxins that gain entry into the cytosol of host cells through receptor-mediated endocytosis and retrograde traffic through the trans-Golgi network (TGN) and endoplasmic reticulum (ER ...
Anastasiya Yermakova +4 more
doaj +1 more source
Role of the Mannose Receptor (CD206) in Innate Immunity to Ricin Toxin
Toxins, 2011 The entry of ricin toxin into macrophages and certain other cell types in the spleen and liver results in toxin-induced inflammation, tissue damage and organ failure.
Emily Gage +4 more
doaj +1 more source
Restricted replication of two alphaviruses in ricin-resistant mouse L cells with altered glycosyltransferase activities [PDF]
, 1979 Charlene Gottlieb +2 more
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Can Large Language Models Design Biological Weapons? Evaluating Moremi Bio [PDF]
arXivAdvances in AI, particularly LLMs, have dramatically shortened drug discovery cycles by up to 40% and improved molecular target identification. However, these innovations also raise dual-use concerns by enabling the design of toxic compounds. Prompting Moremi Bio Agent without the safety guardrails to specifically design novel toxic substances, our ...
arxiv
BiP Negatively Affects Ricin Transport
Toxins, 2013 The AB plant toxin ricin binds both glycoproteins and glycolipids at the cell surface via its B subunit. After binding, ricin is endocytosed and then transported retrogradely through the Golgi to the endoplasmic reticulum (ER).
Kirsten Sandvig +4 more
doaj +1 more source
Insensitivity of a ricin-resistant mutant of Chinese hamster ovary cells to fusion induced by Newcastle disease virus [PDF]
, 1979 Peter G. Polos, William R. Gallaher
openalex +1 more source
Ricin — a potent inhibitor of protein synthesis [PDF]
, 1972 Sjur Olsnes, Alexander Pihl
openalex +1 more source
Differences between ricin and phytohemagglutinins from Ricinus communis seeds [PDF]
, 1973 A. Lugnier, G. Dirheimer
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Inhibition of protein synthesis by ricin: experiments with rat liver mitochondria and nuclei and with ribosomes from Escherichia coli [PDF]
, 1974 Margherita Greco +5 more
openalex +1 more source
Chemical Studies on Toxic Protein “Ricin” in Castor Bean. Part I
, 1959 Masaru Funatsu, Gunki Funatsu
openalex +2 more sources