Results 211 to 220 of about 157,428 (296)

A Novel Small Molecule Accelerates Early Persister Regrowth and Potentiates Antibiotic Killing via MdtL–DcrB

Microbial Biotechnology, Volume 19, Issue 5, May 2026.
bymBDZ accelerates early regrowth of persister‐derived E. coli and potentiates antibiotic killing. Its activity requires the MdtL–DcrB axis and is associated with envelope‐linked transport changes that increase intracellular small‐molecule exposure during recovery, thereby enhancing clearance in early treatment windows. ABSTRACT Persister cells survive
Garin Park, Hyein Kim, Sooyeon Song
wiley   +1 more source

Congenital brucellosis in a preterm infant: A case report from France and literature review. [PDF]

IDCases
Ozcan L, Malorey D, Martin Perceval L, Leroux M, Bridonneau C, Corvec S, Pineau V, Flamant C, Lavigne JP, Launay E.   +9 more
europepmc   +1 more source

Growth Differentiation Factor‐15 Could Predict Decreased Hemoglobin in Tuberculosis Treated With Linezolid‐Containing Regimen

The Clinical Respiratory Journal, Volume 20, Issue 5, May 2026.
Baseline GDF‐15 predicts linezolid‐induced myelosuppression in rifampicin‐resistant tuberculosis. Patients with higher pretreatment GDF‐15 (> 950 pg/mL) were more likely to develop significant hemoglobin decline during therapy. Measuring GDF‐15 before treatment may help identify high‐risk patients and guide safer, personalized linezolid use.
Amaylia Oehadian, Prayudi Santoso, Delita Prihatni, Andini Kartikasari, Ida Parwati, Diah Handayani, Thomas Handoyo, Noorwati Sutandiyo, Bachti Alisjahbana, Dick Menzies, Rovina Ruslami   +10 more
wiley   +1 more source

Deficiency of the Mycobacterial Lipoarabinomannan Biosynthesis Glycosyltransferase MptC Enhances Antibacterial Immune Response and Rifapicin Antibiotic Susceptibility. [PDF]

Antibiotics (Basel)
Hu J, Chen H, Li Z, Sun H, Sun YC, Zhang XL.   +5 more
europepmc   +1 more source

Predicting Pharmacokinetic Variability and Drug Interaction Risk Using Omics‐Based Biomarkers

Clinical and Translational Science, Volume 19, Issue 5, May 2026.
ABSTRACT Interindividual variability in drug pharmacokinetics and susceptibility to drug–drug interactions remain major barriers in precision dosing, particularly for narrow therapeutic index drugs. While genetic factors contribute, much variability arises from dynamic influences such as physiology, disease, age, diet, microbiome, and concomitant ...
Bhagwat Prasad
wiley   +1 more source

A pragmatic trial with an optimized dose of rifampicin and moxifloxacin for the treatment of drug-susceptible pulmonary tuberculosis: a study protocol for open-label, randomized phase III trial (OptiRiMoxTB). [PDF]

Trials
Mlyuka HJ, Liyoyo A, Nyaulingo B, Mpolya E, Kaswaga OL, Semvua H, Lwambura S, McHugh TD, Wildner L, Sabiiti W, Adegbite BR, Nliwasa M, Khosa C, Mbelele P, Mbeya B, Jeremiah K, Boeree MJ, Gillespie SH, Sloan DJ, Mpagama SG, SimpliciTB Consortium.   +20 more
europepmc   +1 more source

Cutaneous non‐tuberculous mycobacterial infections: A retrospective study of 94 cases from Germany

JDDG: Journal der Deutschen Dermatologischen Gesellschaft, Volume 24, Issue 5, Page 608-617, May 2026.
Summary Background Cutaneous non‐tuberculous mycobacterial infections (NTM) remain a diagnostic and therapeutic challenge. The aim of this study was to characterize cutaneous NTM infections in Germany over a 24‐year‐period. Patients and Methods 73 patients with cutaneous NTM infections diagnosed at 17 different German University Hospitals from 2000 ...
Luisa Bopp, Nicolai Deresz, Henning Klapproth, Isabelle Suárez, Jonathan Jantsch, Mario Fabri, Esther von Stebut   +6 more
wiley   +1 more source

Naturally occurring dinactin targets cpsA protein and kills Mycobacterium tuberculosis by disrupting the proton motive force. [PDF]

Commun Biol
Wang G, Dong W, Bai Y, Li Y, Lu H, Lu W, Wang C, Tang J, Li P, Wang R, Wang X, Chen H, Tan C.   +12 more
europepmc   +1 more source

Kutane Infektionen mit nicht‐tuberkulösen Mykobakterien: eine retrospektive Studie mit 94 Fällen aus Deutschland

JDDG: Journal der Deutschen Dermatologischen Gesellschaft, Volume 24, Issue 5, Page 608-618, May 2026.
Zusammenfassung Hintergrund Kutane nichttuberkulöse Mykobakterien‐Infektionen (NTM) sind diagnostisch und therapeutisch herausfordernd. Ziel dieser Studie war die Charakterisierung kutaner NTM‐Infektionen in Deutschland über einen Zeitraum von 24 Jahren. Patienten und Methodik Eingeschlossen wurden 73 Patienten mit kutanen NTM‐Infektionen, die zwischen
Luisa Bopp, Nicolai Deresz, Henning Klapproth, Isabelle Suárez, Jonathan Jantsch, Mario Fabri, Esther von Stebut   +6 more
wiley   +1 more source