Results 221 to 230 of about 157,428 (296)

Dexamethasone‐Mediated Regulation of CYP3A4 and UGTs in Human Hepatoma HuH‐7 Cells

open access: yesFundamental &Clinical Pharmacology, Volume 40, Issue 3, May 2026.
ABSTRACT Background The application of human hepatic cell lines to early drug discovery and development instead of human primary hepatocytes (HPHs) has been limited because of the low level of drug‐metabolizing enzymes (DMEs). Objective The study aimed to evaluate the effects of dexamethasone (DEX) treatment on DME expression, activities, and ...
Hana Yu   +4 more
wiley   +1 more source

Therapeutic drug monitoring-guided treatment of XDR TB with an RpoB I491F mutation-a case report. [PDF]

open access: yesJAC Antimicrob Resist
Klingmüller A   +12 more
europepmc   +1 more source

Hierarchical analysis of unsuccessful tuberculosis treatment among people living with HIV in Brazil using nationwide surveillance data

open access: yesHIV Medicine, Volume 27, Issue 5, Page 710-726, May 2026.
Abstract Introduction People with tuberculosis‐HIV coinfection face multiple barriers to effective treatment, including social vulnerability, stigma and limited access to healthcare. This study examined factors associated with loss to follow‐up and death among individuals with tuberculosis‐HIV in Brazil.
Lucas Vinícius de Lima   +9 more
wiley   +1 more source

Method Validation of an Ultra-High-Performance Liquid Chromatography (UHPLC) for the Bioequivalence Study of Rifampicin. [PDF]

open access: yesActa Med Philipp
Diño AJD   +6 more
europepmc   +1 more source

Clinical and Postoperative Applications of Manuka Honey in Wound Healing: An Evidence‐Based Review

open access: yesInternational Wound Journal, Volume 23, Issue 5, May 2026.
ABSTRACT Chronic and postoperative wounds remain challenging to manage, with high risks of infection, delayed healing and increased costs. Manuka honey offers antibacterial, anti‐inflammatory, antioxidant and tissue‐regenerative properties through methylglyoxal, phenolic compounds, high sugar content and low pH.
Ayman N. Alhabsi   +6 more
wiley   +1 more source

The Ti Plasmid‐Encoded VirJ Functions as a Lysyl‐Phosphatidylglycerol Hydrolase in Agrobacterium tumefaciens

open access: yesMolecular Microbiology, Volume 125, Issue 5, Page 426-441, May 2026.
We identify the long‐known virulence factor VirJ as a lysyl‐phosphatidylglycerol (L‐PG) hydrolase. Like the chromosomally encoded virulence factor AcvB, it prevents excessive accumulation of L‐PG in the membrane, thereby maintaining efficient T‐DNA transfer via the Type IV secretion system (T4SS) in Agrobacterium tumefaciens.
Britta Lotz   +9 more
wiley   +1 more source

‘Candidatus Liberibacter asiaticus’ Effector SDE4250 Targets Citrus Proteasome Protein RPN10 to Inhibit Salicylic Acid‐Mediated Citrus Immunity

open access: yesMolecular Plant Pathology, Volume 27, Issue 5, May 2026.
SDE4250 suppressed 26S proteasome activity by targeting CsRPN10 and enhancing its degradation via the proteasome pathway. This impairment of proteasome function subsequently attenuates SA‐mediated defence responses, thereby increasing citrus susceptibility to promote CLas infection.
Yalin Mei   +7 more
wiley   +1 more source

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