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Rifampicin-resistant Tuberculosis: A Global Health Dilemma
Rahnuma Ahmad +3 more
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Rifampicin resistant Mycobacterium tuberculosis in Vietnam: Comment
Daungsupawong, Hineptch +1 more
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Detection of rifampicin-resistance mutations in Mycobacterium tuberculosis
Lancet, The, 1993Control of tuberculosis is threatened by widespread emergence of drug resistance in Mycobacterium tuberculosis. Understanding the molecular basis of resistance might lead to development of novel rapid methods for diagnosing drug resistance. We set out to determine the molecular basis of resistance to rifampicin, a major component of multidrug regimens ...
Amalio Telenti, T Bodmer, L Matter
exaly +4 more sources
Rifampicin-induced transcriptome response in rifampicin-resistant Mycobacterium tuberculosis
Tuberculosis, 2013Tuberculosis (TB) is still a major life-threatening infectious disease, within which especially the rise of multidrug resistant TB (MDR-TB) is currently worrying. This study focuses on mechanisms of development of rifampicin resistance, since rifampicin seems to play an important role in the development of MDR-TB.
de Knegt, G.J. +8 more
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Acquired resistance to rifampicin by Mycobacterium kansasii
Tubercle, 1976Two patients with Mycobacterium kansasii infection of the lung had organisms sensitive to rifampicin. Following treatment, essentially with rifampicin alone, the patients began to excrete organisms completely resistant to rifampicin. The ability of M. kansasii to acquire resistance to rifampicin during treatment has been clearly demonstrated.
P T, Davidson, R, Waggoner
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Methods and Difficulties of the Resistance Test with Rifampicin
Respiration, 20092,570 strains of tuberculosis bacilli were tested against 12 tuberculostatics and also against the recently marketed compound Rifampicin. The culture medium employed was Löwenstein-Jensen and the solvent for Rifampicin was either DMSO or dimethylformamide; both were equally efficient. Due to a certain instability of the medicament in the culture medium,
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Interspecific transformation of rifampicin resistance in the genus Bacillus
Molecular and General Genetics MGG, 1973Transfer of resistance to rifampicin, a genetic determinant for RNA polymerase, was tested by transformation between B. subtilis as recipient and eight other Bacillus species as DNA donors. Seven of these donors effected transformation of rifampicin as well as erythromycin resistance, and cotransfer of these linked markers was also found in the ...
N, Harford, M, Mergeay
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Rifampicin-resistant replication of coliphage N4 DNA
Nature, 1974IT has recently been reported that rifampicin-sensitive RNA synthesis participates in the replication of bacterial1,2, episome or plasmid3–8 and phage7–11 DNA, presumably in a primer role during initiation. A more complex model of DNA replication may, however, be provided by the development of coliphage N4 (ref. 12).
G C, Schito, M, Giraldi, M, Toni
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Rifampicin with ethambutol for drug-resistant tuberculosis
British Journal of Diseases of the Chest, 1971Abstract Thirty patients have been treated with rifampicin and ethambutol and sometimes with other drugs in addition. All had long-standing advanced tuberculosis with organisms resistant to the standard and often to the older ‘reserve' drugs. Four discharged themselves during the first month of treatment.
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