Results 211 to 220 of about 2,415,366 (239)
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Methods and Difficulties of the Resistance Test with Rifampicin
Respiration, 20092,570 strains of tuberculosis bacilli were tested against 12 tuberculostatics and also against the recently marketed compound Rifampicin. The culture medium employed was Löwenstein-Jensen and the solvent for Rifampicin was either DMSO or dimethylformamide; both were equally efficient. Due to a certain instability of the medicament in the culture medium,
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Rifampicin-resistant replication of coliphage N4 DNA
Nature, 1974IT has recently been reported that rifampicin-sensitive RNA synthesis participates in the replication of bacterial1,2, episome or plasmid3–8 and phage7–11 DNA, presumably in a primer role during initiation. A more complex model of DNA replication may, however, be provided by the development of coliphage N4 (ref. 12).
G C, Schito, M, Giraldi, M, Toni
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Interspecific transformation of rifampicin resistance in the genus Bacillus
Molecular and General Genetics MGG, 1973Transfer of resistance to rifampicin, a genetic determinant for RNA polymerase, was tested by transformation between B. subtilis as recipient and eight other Bacillus species as DNA donors. Seven of these donors effected transformation of rifampicin as well as erythromycin resistance, and cotransfer of these linked markers was also found in the ...
N, Harford, M, Mergeay
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Rifampicin with ethambutol for drug-resistant tuberculosis
British Journal of Diseases of the Chest, 1971Abstract Thirty patients have been treated with rifampicin and ethambutol and sometimes with other drugs in addition. All had long-standing advanced tuberculosis with organisms resistant to the standard and often to the older ‘reserve' drugs. Four discharged themselves during the first month of treatment.
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RFA1 Inhibits Rifampicin-resistant RNA Polymerase by a Similar Mechanism as Rifampicin
Journal of Molecular BiologyThe anti-tuberculosis agent rifampicin functions by binding to RNA polymerase (RNAP) around the active centre Mg2+ and sterically prevents the synthesis of RNA products greater than 2-3 nt in length. In the rifampicin-resistant TB strains, the amino acid residues at/near the rifampicin-binding site on RNAP are substituted by other residues.
Sourajit Saha +4 more
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Management of individuals exposed to multidrug-resistant or rifampicin-resistant tuberculosis
The Lancet Infectious DiseasesIndividuals exposed to a person with infectious multidrug-resistant or rifampicin-resistant (MDR-RR) tuberculosis are at risk of developing tuberculosis disease. Historically, insufficient empirical evidence for preventive treatment in this group has permitted inadequate guidance for clinical decision making.
James A, Seddon +37 more
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The pattern of resistance development to rifampicin in mycobacterium tuberculosis
Tubercle, 1972Abstract Pattern of resistance development to rifampicin of tubercle bacilli is an obligatory ‘single-step' pattern. There is only one phenotype of resistance to rifampicin. Tubercle bacilli are either susceptible or resistant to this antibiotic, and there is no intermediate level of resistance between sensitivity and high resistance.
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Development of Drug Resistance to Rifampicin
Chemotherapy, 2009A, Manten, L J, Van Wijngaarden
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Rifampicin-resistant tuberculosis
The Lancet, 1995BeverleyA Wynne, Sunil Gupta
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Antibiotic Resistance in the Patient With Cancer: Escalating Challenges and Paths Forward
Ca-A Cancer Journal for Clinicians, 2021Amila K Nanayakkara, David E Greenberg
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