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The impact of rifampin on the efficacy of implant retention and prosthesis removal in staphylococcal periprosthetic joint infection [PDF]

Frontiers in Cellular and Infection Microbiology
ObjectivesThe purpose of this study was to evaluate the impact of adjunctive rifampicin therapy on the outcomes of prosthesis retention versus removal in patients with staphylococcal prosthetic joint infection (PJI) undergoing antibacterial treatment ...
Canhong Zhang, Canhong Zhang, Canhong Zhang, Canhong Zhang, Juncheng Li, Juncheng Li, Juncheng Li, Lan Lin, Lan Lin, Lan Lin, Mingzhong Liu, Yang Chen, Yang Chen, Yang Chen, Yuanqing Cai, Yuanqing Cai, Yuanqing Cai, Jiexin Huang, Zida Huang, Zida Huang, Zida Huang, Chaofan Zhang, Chaofan Zhang, Chaofan Zhang, Wenming Zhang, Wenming Zhang, Wenming Zhang, Xinyu Fang, Xinyu Fang, Xinyu Fang, Wenbo Li, Wenbo Li, Wenbo Li   +32 more
doaj   +2 more sources

Etymologia: Rifampin [PDF]

Emerging Infectious Diseases, 2018
Ronnie Henry
doaj   +2 more sources

Rifampin-loaded Mesoporous Silica Nanoparticles Improved Physical and Mechanical Properties and Biological Response of Acrylic Bone Cement [PDF]

Journal of Medical Signals and Sensors
Background: Acrylic bone cement, which is used to fix implants in the knee and hip, is prone to contamination with various types of infections. Adding small amounts of different antibiotics to the cement can help prevent and treat infections.
Mohammad Reza Shafiei, Nader Nezafati, Saeed Karbasi, Anousheh Zargar Kharazi   +3 more
doaj   +2 more sources

Activity of contezolid against methicillin-resistant Staphylococcus aureus in a rat model of foreign body osteomyelitis [PDF]

Microbiology Spectrum
Contezolid has activity against methicillin-resistant Staphylococcus aureus (MRSA), a common cause of orthopedic infection. In a rat model of foreign body osteomyelitis, 1.3 log10 cfu/g bone and 0.5 log10 cfu/k-wire reduction in MRSA was found in tibiae (
Sebastian C. Herren, Melissa J. Karau, Christina Koscianski, Kerryl E. Greenwood-Quaintance, Jayawant N. Mandrekar, Wen Wang, Robin Patel   +6 more
doaj   +2 more sources

Enhanced Biofilm Disruption in Methicillin-Resistant Staphylococcus aureus Using Rifampin and Fluoroquinolone Combinations [PDF]

Pathogens
Staphylococcus aureus biofilms complicate the treatment of device-related infections. We hypothesized that combining rifampin with fluoroquinolones could eradicate biofilms even in antimicrobial-resistant S. aureus strains.
Yu Ri Kang, Joo-Young Park, Doo Ryeon Chung, Minhee Kang, Jae-Hoon Ko, Kyungmin Huh, Sun Young Cho, Cheol-In Kang, Kyong Ran Peck   +8 more
doaj   +2 more sources

Differential effects of cotreatment of the antibiotic rifampin with host-directed therapeutics in reducing intracellular Staphylococcus aureus infection [PDF]

PeerJ, 2020
Background Chronic infection by Staphylococcus aureus drives pathogenesis in important clinical settings, such as recurrent pulmonary infection in cystic fibrosis and relapsing infection in osteomyelitis. Treatment options for intracellular S.
Melissa D. Evans, Robert Sammelson, Susan McDowell   +2 more
doaj   +2 more sources

Delayed Rifampin Administration in the Antibiotic Treatment of Periprosthetic Joint Infections Significantly Reduces the Emergence of Rifampin Resistance

Antibiotics, 2021
Rifampin is one of the most important biofilm-active antibiotics in the treatment of periprosthetic joint infection (PJI), and antibiotic regimens not involving rifampin were shown to have higher failure rates.
Ali Darwich, Franz-Joseph Dally, Mohamad Bdeir, Katharina Kehr, Thomas Miethke, Svetlana Hetjens, Sascha Gravius, Elio Assaf, Elisabeth Mohs   +8 more
doaj   +1 more source

Comparing the Synergistic and Antagonistic Interactions of Ciprofloxacin and Levofloxacin Combined with Rifampin against Drug-Resistant Staphylococcus aureus: A Time–Kill Assay

Antibiotics, 2023
Background: Treatment of device-related infections by drug-resistant Staphylococcus aureus can be challenging, and combination therapy has been proposed as a potential solution.
Yu Ri Kang, Doo Ryeon Chung, Jae-Hoon Ko, Kyungmin Huh, Sun Young Cho, Cheol-In Kang, Kyong Ran Peck   +6 more
doaj   +1 more source

Comparative evaluation of critical concentrationsfor detecting borderline rifampin resistance in Mycobacterium tuberculosis

Annals of Clinical Microbiology, 2023
Background: Rifampin plays an important role in tuberculosis treatment. In recent years, the introduction of molecular testing techniques has enabled the rapid detection of rifampin resistance, leading to discrepancies with conventional methods.
Chang-Ki Kim, Hee Jae Huh, Jeong Su Park, Taesoung Kim, Jae Han Sohn   +4 more
doaj   +1 more source

Diagnosis and Interim Treatment Outcomes from the First Cohort of Multidrug-Resistant Tuberculosis Patients in Tanzania. [PDF]

, 2013
Kibong'oto National Tuberculosis Hospital (KNTH), Kilimanjaro, Tanzania. Characterize the diagnostic process and interim treatment outcomes from patients treated for multidrug-resistant tuberculosis (MDR-TB) in Tanzania.
Boeree, Martin J, Gratz, Jean, Heysell, Scott K, Houpt, Eric R, Kibiki, Gibson S, Kisonga, Riziki M, Kumburu, Happiness H, Lekule, Isack A, Mpagama, Stellah G, Ndusilo, Nora D   +9 more
core   +12 more sources