Results 91 to 100 of about 51,024 (230)

Triple Threat: Elucidating Evolution Under Antibiotic, Metal, and Phage Pressure in Escherichia coli

Ecology and Evolution, Volume 16, Issue 9, September 2026.
Antibiotic resistance threatens treatment of bacterial infections, increasing research into alternative therapies, in particular whether new resistances will arise to these novel treatments. We evolved bacteria under phage, antibiotic, and heavy metal exposure.
Lindsey W. McGee, Noah K. Radtke, Gretchen S. Taylor, Joseph L. Graves Jr., Liesl Jeffers‐Francis   +4 more
wiley   +1 more source

Relationship between antibiotic concentration in bone and efficacy of treatment of staphylococcal osteomyelitis in rats: azithromycin compared with clindamycin and rifampin

, 1992
We examined the effect of azithromycin (CP-62,993), a new oral macrolide-like antibiotic, alone and in combination with rifampin, as treatment for experimental staphylococcal osteomyelitis. Clindamycin was used as a comparison drug.
Sande, E, Täuber, MG, Kunz, S, Zak, O, O'Reilly, T, Sande, MA   +5 more
core   +1 more source

Activity of contezolid against methicillin-resistant Staphylococcus aureus in a rat model of foreign body osteomyelitis

Microbiology Spectrum
Contezolid has activity against methicillin-resistant Staphylococcus aureus (MRSA), a common cause of orthopedic infection. In a rat model of foreign body osteomyelitis, 1.3 log10 cfu/g bone and 0.5 log10 cfu/k-wire reduction in MRSA was found in tibiae (
Sebastian C. Herren, Melissa J. Karau, Christina Koscianski, Kerryl E. Greenwood-Quaintance, Jayawant N. Mandrekar, Wen Wang, Robin Patel   +6 more
doaj   +1 more source

Hypercalcemia in a Patient With Spinal Tuberculosis and Aspergillus Co‐Infection: A Case‐Report

Immunity, Inflammation and Disease, Volume 14, Issue 9, September 2026.
ABSTRACT Background Tuberculosis (TB), one of the leading infectious causes of mortality worldwide, may disseminate hematogenously and result in extrapulmonary manifestations. Spinal tuberculosis (ST) is an uncommon but serious form of extrapulmonary TB.
Negin Parsa, Amirpasha Amlelshahbaz, Hamidreza Soltani   +2 more
wiley   +1 more source

Warfarin-Rifampin Drug Interaction in a Pediatric Patient

, 2017
Rifampin has been documented to significantly attenuate the effect of warfarin in adult patients. No data have been presented on the use of rifampin and warfarin in a pediatric patient.
Donald L. Yee, Brady S. Moffett, Michael Poon   +2 more
core   +1 more source

Rifampin monotherapy for multidrug-resistant Chryseobacterium indologenes meningitis unresponsive to trimethoprim-sulfamethoxazole: a case report and review of the literature

Frontiers in Medicine
Multidrug-resistant (MDR) Chryseobacterium indologenes is an emerging pathogen causing challenging central nervous system (CNS) infections, for which there are no standardized treatment guidelines.
Dongchuan Shao, Zhe Li, Zhiwei Cao, Zhou Yang, Wenbiao Huang, Kuairong Pu, Jun Wu, Nan Zhao   +7 more
doaj   +1 more source

Reproductive Futures in Focus: Contraceptive Choices Among Individuals With Cystic Fibrosis—Patterns, Preferences, and Influencing Factors

Pediatric Pulmonology, Volume 61, Issue 9, September 2026.
ABSTRACT Introduction Advancements in the care of people with cystic fibrosis (PwCF) have made discussions about reproductive health increasingly important. Rising rates of both intended and unintended pregnancies highlight the need for effective contraception counseling.
Kevin P. Lonabaugh, HollyAnn Jacobs, Jordan Orofino, Leanne Saville, Brittany A. Wright   +4 more
wiley   +1 more source

Unpredictable Effects of Rifampin as an Adjunctive Agent in Elimination of Rifampin-Susceptible and -Resistant Staphylococcus aureus Strains Grown in Biofilms

, 2010
The use of rifampin as an adjunct in biofilm-associated infections is based on the ability to penetrate into biofilms and a presumed activity against dormant bacteria.
Stobberingh, Ellen E., Patrick S. Beisser, Cees Neef, Neef, Cees, Sander Croes, Beisser, Patrick S., Cathrien A. Bruggeman, Bruggeman, Cathrien A., Croes, Sander, Ellen E. Stobberingh   +9 more
core   +1 more source

Prevalencia de la resistencia de Mycobacterium tuberculosis a quinolonas y fármacos inyectables en Colombia, 2012-2013

Biomédica: revista del Instituto Nacional de Salud, 2017
Introducción. La tuberculosis es un problema de salud pública a nivel mundial. En 2014, la Organización Mundial de la Salud estimó que se habían presentado 9,6 millones de casos nuevos y 480.000 multirresistentes.
Claudia Llerena, Angie Zabaleta, Angélica Valbuena, Martha Murcia   +3 more
doaj   +1 more source

A Practical Alternative to Refine the Estimate of fmCYP3A4 and Evaluate Drug–Drug Interaction Potential for Ziftomenib Using PBPK Modeling to Inform Labeling

CPT: Pharmacometrics &Systems Pharmacology, Volume 15, Issue 9, September 2026.
ABSTRACT Accurate physiologically based pharmacokinetic (PBPK) simulation of drug–drug interaction (DDI) potential requires estimation of the relative contribution of the impacted pathway. While fraction metabolized by CYP enzymes is usually estimated using dedicated clinical DDI studies with strong CYP inhibitors, this approach might not be available ...
Ian E. Templeton, Chara Litou, Hannah M. Jones, Julie Mackey Ahsan, Marilyn Tabachri, Mollie Leoni, Amitava Mitra   +6 more
wiley   +1 more source