Results 51 to 60 of about 46,701 (237)

Maralixibat for the treatment of severe xanthomas in two children with Alagille syndrome: Case reports

JPGN Reports, EarlyView.
Abstract Alagille syndrome (ALGS) is a rare, autosomal dominant disorder which presents with a broad range of clinical manifestations, including cholestatic pruritus. A unique manifestation of ALGS is the presence of xanthomas in 24%–42% of patients, which can lead to liver transplantation.
Geetanjali Bora, Ruben E. Quiros‐Tejeira, Bernadette Vitola   +2 more
wiley   +1 more source

Mycobacterial SigA and SigB Cotranscribe Essential Housekeeping Genes during Exponential Growth

mBio, 2019
Mycobacterial σB belongs to the group II family of sigma factors, which are widely considered to transcribe genes required for stationary-phase survival and the response to stress.
Kelley Hurst-Hess, Rajesh Biswas, Yong Yang, Paulami Rudra, Erica Lasek-Nesselquist, Pallavi Ghosh   +5 more
doaj   +1 more source

Structural basis of rifampin inactivation by rifampin phosphotransferase [PDF]

Proceedings of the National Academy of Sciences, 2016
Significance Rifampin phosphotransferases (RPH) belong to a recently identified antibiotic-resistance protein family that inactivates rifampin, the first-line drug against tuberculosis, by phosphorylation. By determining the structures of RPH from Listeria monocytogenes (LmRPH) in different conformations ...
Xiaofeng Qi, Wei Lin, Miaolian Ma, Chengyuan Wang, Yang He, Nisha He, Jing Gao, Hu Zhou, Youli Xiao, Yong Wang, Peng Zhang   +10 more
openaire   +2 more sources

Characteristics and Clinical Outcomes of Patients With Hidradenitis Suppurativa (HS) Treated With Bimekizumab: A Canadian Retrospective Chart Review

JEADV Clinical Practice, EarlyView.
ABSTRACT Background Hidradenitis suppurativa (HS) is a chronic, recurrent inflammatory skin disease characterised by painful nodules, abscesses, and draining and non‐draining tunnels. Currently, there are two biologics approved in Canada for the treatment of moderate‐to‐severe HS, adalimumab (anti‐TNF) and secukinumab (anti‐IL‐17A).
Irina Turchin, Tracey Brown‐Maher, Hélène Veillette, David O. Croitoru, Kyle Cullingham   +4 more
wiley   +1 more source

Rifampin-loaded Mesoporous Silica Nanoparticles Improved Physical and Mechanical Properties and Biological Response of Acrylic Bone Cement

Journal of Medical Signals and Sensors
Background: Acrylic bone cement, which is used to fix implants in the knee and hip, is prone to contamination with various types of infections. Adding small amounts of different antibiotics to the cement can help prevent and treat infections.
Mohammad Reza Shafiei, Nader Nezafati, Saeed Karbasi, Anousheh Zargar Kharazi   +3 more
doaj   +1 more source

Fatal spinal cord compression in a horse with chronic actinobacterial cranial nuchal bursitis

Equine Veterinary Education, EarlyView.
Summary A 14‐year‐old warmblood gelding was managed for waxing and waning cranial nuchal bursitis for 2 years. Intensive medical and surgical management was not curative, and the patient was subjected to euthanasia after becoming acutely recumbent. Ante‐mortem and post‐mortem next generation sequencing of bursal tissue and post‐mortem conventional PCR ...
H. Mesch, C. Frank, J. B. Daniels, E. Acutt, E. Contino   +4 more
wiley   +1 more source

Reassessment of the genetic basis of natural rifampin resistance in the genus Rickettsia

MicrobiologyOpen
Rickettsia, a genus of obligate intracellular bacteria, includes species that cause significant human diseases. This study challenges previous claims that the Leucine‐973 residue in the RNA polymerase beta subunit is the primary determinant of rifampin ...
Julien Amoros, Noor Fattar, Marie Buysse, Meriem Louni, Joanne Bertaux, Didier Bouchon, Olivier Duron   +6 more
doaj   +1 more source

Plasma C‐reactive protein and interleukin‐6 concentrations in foals during health and respiratory disease

Equine Veterinary Journal, EarlyView.
Abstract Background Early and specific diagnosis of bronchopneumonia in foals is important to prevent severe disease. In human medicine, C‐reactive protein (CRP) and interleukin‐6 (IL‐6) are important diagnostic and prognostic biomarkers in neonatal pneumonia in other species.
Dorothea Hildebrandt, Monica Venner, Kelsey A. Hart, Londa Berghaus   +3 more
wiley   +1 more source

The potential value of cytokine, cortisol and vitamin D profiles in foals from birth to weaning for respiratory disease prediction on a farm endemic for Rhodococcus equi pneumonia

Equine Veterinary Journal, EarlyView.
Abstract Background Rhodococcus equi causes pneumonia in young foals, but disease susceptibility and severity vary. Cortisol and vitamin D modulate immune responses and cytokine production during bacterial infection, and altered concentrations are associated with sepsis in neonatal foals. We hypothesised an age and disease effect on circulating steroid
Londa J. Berghaus, Monica Venner, Hannah Helbig, Dorothea Hildebrandt, Kelsey Hart   +4 more
wiley   +1 more source

Pathogenesis and Therapeutics for Chronic Pruritus of Unknown Origin: A Systematic Review

International Journal of Dermatology, EarlyView.
ABSTRACT Chronic pruritus of unknown origin (CPUO) is a distressing condition characterized by persistent itch lasting over 6 weeks without an identifiable cause. The underlying mechanisms remain poorly understood, complicating diagnosis and treatment.
Yagiz Matthew Akiska, Isha Gandhi, Robert Adler, Deena Fayyad, Perya Bhagchandani, Shabnam Afzal, Waleed Adawi, Shivani Patel, Shawn G. Kwatra   +8 more
wiley   +1 more source