Results 41 to 50 of about 7,735 (212)
Nature Communications, 2018 Resistance to rifamycin antibiotics, which target bacterial RNA polymerases, is a growing problem. Here, the authors identify gene clusters from soil metagenomes encoding production of rifamycin analogues that are active against rifampicin-resistant ...
James Peek +16 more
doaj +1 more source
Stereochemical Assignment of Intermediates in the Rifamycin Biosynthetic Pathway by Precursor-Directed Biosynthesis [PDF]
, 2016 Natural and semisynthetic rifamycins are clinically important inhibitors of bacterial DNA-dependent RNA polymerase. Although the polyketide-nonribosomal peptide origin of the naphthalene core of rifamycin B is well established, the absolute and relative ...
Mathew A. Rude (2673727) +4 more
core +1 more source
Machine Learning Accelerates Crystallization for Structure Determination
Angewandte Chemie, Volume 138, Issue 25, 15 June 2026.Single‐crystal X‐ray diffraction (SCXRD) is often constrained by the difficulty of obtaining suitable crystals. Here, a machine learning‐accelerated co‐crystal discovery workflow is established for a crystalline mate strategy that achieves over 95% prediction accuracy and experimentally delivers 114 co‐crystals from 120 candidates.
Cui‐Zhou Luan +10 more
wiley +2 more sources
Advanced Science, EarlyView.Dominant antimicrobial resistance reservoirs in Klebsiella pneumoniae vary across eco‐geographic settings rather than following a universal pattern. Integrated One Health and global genomic analyses show that lineage structure, integron load, and cross‐niche connectivity shape whether AMR burden accumulates primarily in human or nonhuman compartments ...
Hui Lin +12 more
wiley +1 more source
Microbial Transformation of Rifamycin: A Novel Approach to Rifamycin Derivatives [PDF]
, 2003 370-377Biotransformation of an ansamycin group of antibiotic, rifamycin B (clinically less active) to a more potent antibiotic rifamycin S, involves the action of rifamycin oxidase.
Chincholkar, S B +4 more
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British Journal of Clinical Pharmacology, EarlyView.Abstract Aim Balcinrenone (previously AZD9977) is a novel selective non‐steroidal mineralocorticoid receptor antagonist (MRA) with a differential mechanism of action relative to approved MRAs. The aim of this trial was to assess the pharmacokinetics, safety and tolerability of balcinrenone in participants with mild and moderate hepatic impairment ...
Anna L. Eriksson +8 more
wiley +1 more source
, 2013 Rifamycin derivs., such as I [R is hydrogen or acetyl R1 and R2 are independently selected from the group consisting of hydrogen, ( C1-4) alkyl, benzyloxy, mono- and di-(C1-3) alkylamino-(C1-4)alkyl, (C1-3)alkoxy, (C1-4) alkyl, hydroxy-Me ...
M. Campana +5 more
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The in vitro efficacy of Nitrofurazone-Rifamycin combination [PDF]
, 2002 Rifamycin and nitrofurazone combination in the form of a hand made mesh is widely used empirically in wound care, with a considerable success in Turkey. Despite this widespread use, we are unable to find any information in the literature about the use of
Sumer, Z +5 more
core +3 more sources
Food Safety and Health, EarlyView.ABSTRACT Azithromycin has been used for clinical invasive infections caused by fluoroquinolone‐ and third‐generation cephalosporin‐resistant Salmonella, and mass drug administration with azithromycin has been used to reduce under‐5 mortality in children in some countries.
Yuhang Pei +4 more
wiley +1 more source
International Journal of Mycobacteriology, 2017 Introduction: Information on the long-term treatment outcome following nontuberculous mycobacterial (NTM) lymphadenitis is very limited. We performed a study to (a) compare cure rates following different initial treatment courses, (b) describe subsequent
Annicka Reuss +4 more
doaj +1 more source