Results 1 to 10 of about 6,031 (156)

Blocking ADP-ribosylation expands the anti-mycobacterial spectrum of rifamycins

Microbiology Spectrum, 2023
The clinical utility of rifamycins against non-tuberculous mycobacterial (NTM) disease is limited by intrinsic drug resistance achieved by ADP-ribosyltransferase Arr.
Uday S Ganapathy, Tian Lan, Véronique Dartois   +2 more
exaly   +3 more sources

A macroevolution-inspired approach to reveal novel antibiotic resistance mechanisms [PDF]

eLife
With the continuous rise in antibiotic resistance, novel methods that can reveal currently unknown antibiotic resistance mechanisms are essential to prepare and inform health responses and novel antibiotic discovery campaigns. Here, we built a library of
Fernanda T Subtil, Teresa FG Machado, Holly Douglas, Joanna M Kirkpatrick, Mark Skehel, Acely Garza-Garcia, Luiz Pedro S de Carvalho   +6 more
doaj   +2 more sources

Late-Stage Functionalization of the Rifamycin Core via Click Chemistry Toward New Antibacterial Derivatives [PDF]

Molecules
Antimicrobial resistance (AMR) threatens global health, particularly through the rise of multidrug-resistant tuberculosis (MDR-TB) and other critical bacterial infections such as methicillin-resistant Staphylococcus aureus (MRSA).
Lola Beeser, Daniel Armstrong, Marissa S. Fullerton, Isabella Beasley, Wyatt Treadway, Clara Nikkel, Mai Lan Ho, Braden Glenn, Catherine Mills, Shailesh Budhathoki, Jessie Parchman, Ryan Holdiness, Jake Smith, Zachary Hodge, Amanda L. Dragan, Mohammad Abrar Alam, Robert C. Shields, Daniel E. Voth, Irosha N. Nawarathne   +18 more
doaj   +2 more sources

In vitro activity of rifampicin, rifapentine and rifabutin in combination with their 25-deacetyl-metabolites against various Mycobacterium tuberculosis lineages [PDF]

Annals of Clinical Microbiology and Antimicrobials
Objectives Rifamycin agents (rifampicin (RIF), rifapentine (RFP), rifabutin (RFB)) are the cornerstone of tuberculosis (TB) therapy. Rifamycins are metabolized into 25-deacetyl-metabolites, which have been described has active and may contribute to in ...
Charlotte Genestet, Chloé Bourg, Elisabeth Hodille, Olivier Bahuaud, Florence Ader, Sylvain Goutelle, Oana Dumitrescu, On behalf of the Lyon TB study group   +7 more
doaj   +2 more sources

Evaluating the efficacy of HRZE-based regimens in a high-burden murine model: a back-translational assessment of rifamycins and moxifloxacin substitutions in tuberculosis treatment [PDF]

Frontiers in Pharmacology
IntroductionThe standard treatment for tuberculosis is the isoniazid, rifampicin, pyrazinamide, and ethambutol (HRZE) regimen. Despite its efficacy, this regimen has limitations, including prolonged treatment duration and poor clinical outcomes in drug ...
Jason E. Cummings, Lisa K. Woolhiser, Vincent Guglielmi, Machenzie Wernsman, Ashley Romano, Samantha Pauly, Samantha Pauly, John T. Belisle, Nicholas D. Walter, Nicholas D. Walter, Nicholas D. Walter, Gregory T. Robertson, Gregory T. Robertson, Richard A. Slayden   +13 more
doaj   +2 more sources

Rifampin mediated decapsulation and enhanced bacterial clearance: a new mechanism of rifamycinsResearch in context [PDF]

EBioMedicine
Summary: Background: Many clinically relevant bacterial pathogens are encapsulated, as exemplified by Salmonella enterica serovar Typhi. S. Typhi, the causative agent of the life-threatening systemic disease typhoid fever, expresses Vi as the outermost ...
Gi Young Lee, Jeongmin Song
doaj   +2 more sources

Metagenomic analysis revealed the distribution of antibiotic resistance genes of Awang sheep (Ovis aries) gut microbiota [PDF]

Frontiers in Microbiology
Antimicrobial resistance (AMR) in livestock is a major contributor to the global AMR crisis, yet little is known about its dynamics in high-altitude pastoral systems.
Siyue Zhao, Xinping Wang, Heran Zhu, Ge Guo, Ghulam Raza Mustafa, Ahsan Mustafa, Yu Chen, Xiangle Li, Ying Wang, Bi Zhao   +9 more
doaj   +2 more sources

Comparison of Rifamycins for Efficacy Against Mycobacterium avium Complex and Resistance Emergence in the Hollow Fiber Model System

Frontiers in Pharmacology, 2021
Rifamycins are integral part of the combination regimen for treatment of pulmonary Mycobacterium avium-complex [MAC] infection, but different practitioners prefer different rifamycins.
Gunavanthi D. Boorgula, Laxmi U. M. R. Jakkula, Tawanda Gumbo, Bockgie Jung, Shashikant Srivastava, Shashikant Srivastava   +5 more
doaj   +1 more source

Going Retro, Going Viral: Experiences and Lessons in Drug Discovery from COVID-19

Molecules, 2022
The severity of the COVID-19 pandemic and the pace of its global spread have motivated researchers to opt for repurposing existing drugs against SARS-CoV-2 rather than discover or develop novel ones.
Bing Wang, Dmitri Svetlov, Dylan Bartikofsky, Christiane E. Wobus, Irina Artsimovitch   +4 more
doaj   +1 more source

Bioprospecting for the soil-derived actinobacteria and bioactive secondary metabolites on the Western Qinghai-Tibet Plateau

Frontiers in Microbiology, 2023
IntroductionThe increase in incidence of multidrug-resistant bacteria and the inadequacy of new antimicrobial drugs have led to a widespread outbreak of bacterial antimicrobial resistance.
Lifang Liu, Yuyu Liu, Yuyu Liu, Shaowei Liu, Shaowei Liu, Arina A. Nikandrova, Arina A. Nikandrova, Arina N. Imamutdinova, Arina N. Imamutdinova, Dmitrii A. Lukianov, Dmitrii A. Lukianov, Ilya A. Osterman, Ilya A. Osterman, Petr V. Sergiev, Petr V. Sergiev, Benyin Zhang, Dejun Zhang, Feina Li, Feina Li, Chenghang Sun, Chenghang Sun, Chenghang Sun, Chenghang Sun   +22 more
doaj   +1 more source