Results 1 to 10 of about 6,661 (161)
Frontiers in Microbiology, 2020 Rifamycin derivatives, such as rifampicin, have potent antibiotic activity and have long been used in the clinic as mainstay components for the treatment of tuberculosis, leprosy, and AIDS-associated mycobacterial infections. However, the extensive usage
Bin Xu, Hua Yuan, Gong-Li Tang
exaly +3 more sources
Genome Mining Reveals Rifamycin Biosynthesis in a Taklamakan Desert Actinomycete [PDF]
MicroorganismsActinomycetes are recognized for producing diverse bioactive natural products, yet most biosynthetic gene clusters (BGCs) remain inactive under laboratory conditions.
Xinrong Luo +6 more
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Late-Stage Functionalization of the Rifamycin Core via Click Chemistry Toward New Antibacterial Derivatives [PDF]
MoleculesAntimicrobial resistance (AMR) threatens global health, particularly through the rise of multidrug-resistant tuberculosis (MDR-TB) and other critical bacterial infections such as methicillin-resistant Staphylococcus aureus (MRSA).
Lola Beeser +18 more
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A macroevolution-inspired approach to reveal novel antibiotic resistance mechanisms [PDF]
eLifeWith the continuous rise in antibiotic resistance, novel methods that can reveal currently unknown antibiotic resistance mechanisms are essential to prepare and inform health responses and novel antibiotic discovery campaigns. Here, we built a library of
Fernanda T Subtil +6 more
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In vitro activity of rifampicin, rifapentine and rifabutin in combination with their 25-deacetyl-metabolites against various Mycobacterium tuberculosis lineages [PDF]
Annals of Clinical Microbiology and AntimicrobialsObjectives Rifamycin agents (rifampicin (RIF), rifapentine (RFP), rifabutin (RFB)) are the cornerstone of tuberculosis (TB) therapy. Rifamycins are metabolized into 25-deacetyl-metabolites, which have been described has active and may contribute to in ...
Charlotte Genestet +7 more
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Biomedicines, 2023 Background: The coexistence of lung cancer and tuberculosis is not rare. Rifamycin plays a pivotal role in anti-tuberculosis therapy. However, its potential impact on the liver metabolism of oncology drugs raises concerns.
Ho-Sheng Lee +2 more
doaj +1 more source
Topical Rifamycin Prophylaxis in Gynecological and Obstetric Surgery
Gynecology Obstetrics & Reproductive Medicine, 2022 OBJECTIVE: Antibiotic prophylaxis is one of the most important steps to reduce surgical site infections. First-generation cephalosporin (cefazolin) is used prophylactically in the majority of operations.
Nahit Ata +5 more
doaj +1 more source
Rifampin-divalproex drug-drug interaction in an adult patient: A case report [PDF]
Mental Health Clinician, 2021 The divalproex (DVP) package insert states that rifampin may increase the oral clearance of valproate by 40% and that valproic acid derivative dose adjustments may be required when starting or stopping rifampin. However, the overall clinical significance
Christine Doran, PharmD +3 more
doaj +1 more source
Cumhuriyet Dental Journal, 2020 Objectives: To assess differential effects of different materials combined with allograft on bone-to-implant contact and newly formed bone formation in dental implants with coronal defects histomorphometrically.
Hasan Yeler +5 more
doaj +1 more source
Rifamycin W Analogues from Amycolatopsis mediterranei S699 Δrif-orf5 Strain
Biomolecules, 2021 Rifamycin W, the most predominant intermediate in the biosynthesis of rifamycin, needs to undergo polyketide backbone rearrangement to produce rifamycin B via an oxidative cleavage of the C-12/C-29 double bond.
Yanrong Shi +5 more
doaj +1 more source