A feedback regulatory model for RifQ-mediated repression of rifamycin export in Amycolatopsis mediterranei [PDF]
Microbial Cell Factories, 2018 Background Due to the important role of rifamycin in curing tuberculosis infection, the study on rifamycin has never been stopped. Although RifZ, which locates within the rifamycin biosynthetic cluster, has recently been characterized as a pathway ...
Chao Lei +5 more
doaj +2 more sources
Stability of Non-Ionic Surfactant Vesicles Loaded with Rifamycin S [PDF]
Pharmaceutics, 2022 These days, the eradication of bacterial infections is more difficult due to the mechanism of resistance that bacteria have developed towards traditional antibiotics.
Verdiana Marchianò +5 more
doaj +2 more sources
Rifamycin O, An Alternative Anti-Mycobacterium abscessus Agent [PDF]
Molecules, 2020 Mycobacterium abscessus is the most difficult-to-treat nontuberculous mycobacteria because of its resistance to many antibiotics. In this study, we screened the Korea Chemical Bank library for a bioluminescent reporter assay to identify molecules capable
Bui Thi Bich Hanh +8 more
doaj +2 more sources
Possible Ototoxic Effects of Topical Rifamycin Application: An Electrophysiological and Ultrastructural Study [PDF]
Turkish Archives of Otorhinolaryngology, 2017 Objective:This study aimed to investigate possible ototoxicity associated with topical rifamycin application via electrophysiological tests and ultrastructural examinations.Methods:Electrophysiological assessment was performed with tympanometry, auditory
Cihan Abaylı +6 more
doaj +2 more sources
8-Deoxy-Rifamycin Derivatives from Amycolatopsis mediterranei S699 ΔrifT Strain [PDF]
Biomolecules, 2020 Proansamycin X, a hypothetical earliest macrocyclic precursor in the biosynthesis of rifamycin, had never been isolated and identified. According to bioinformatics analysis, it was proposed that RifT (a putative NADH-dependent dehydrogenase) may be a ...
Feng Ye +6 more
doaj +2 more sources
Deciphering the late steps of rifamycin biosynthesis [PDF]
Nature Communications, 2018 The enzymes Rif15 and Rif16 are involved in the late steps of the biosynthesis of rifamycins, a group of antibiotics. Here, the authors characterized these two proteins and found that they catalyse unusual biochemical reactions.
Feifei Qi +11 more
doaj +2 more sources
Improved Rifamycin B Production by Nocardia mediterranei MTCC 14 under Solid-State Fermentation through Process Optimization [PDF]
Biochemistry Research International, 2014 Optimization of various production parameters using response surface methodology (RSM) was performed to assess maximum yield of rifamycin B from Nocardia mediterranei MTCC 14.
Basavaraj M. Vastrad +4 more
doaj +2 more sources
Genomic modifications for enhanced antibiotic production in rifamycin derivative-producing Amycolatopsis mediterranei S699 strains: focusing on rifQ and rifO genes [PDF]
Frontiers in AntibioticsRifamycin and its derivatives are natural products that belong to the class of antibiotic-active polyketides and have significant therapeutic relevance within the therapy scheme of tuberculosis, a worldwide infectious disease caused by Mycobacterium ...
Moritz Müller +5 more
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MICs for rifamycin compounds determined in RPMI-1640. [PDF]
, 2023 MICs for rifamycin compounds determined in RPMI-1640.
Peggy Lu (6997196) +8 more
core +1 more source
Titrations of Rifamycin SV. [PDF]
, 2023 Survival of V. cholerae N16961 WT and ΔompU in the presence of varying concentrations of rifamycin SV. Statistical comparisons were performed using two-way ANOVA analyses followed by a Bonferroni’s multiple comparison test.
Trudy-Ann Grant (14846215) +3 more
core +1 more source