Results 71 to 80 of about 6,382 (203)

Quality by Design‐Based Development of a Robust LC Method for Simultaneous Estimation of Process‐ and Degradation‐Related Impurities in Rifapentine Drug Product for the Treatment of Active and Latent Tuberculosis

open access: yesBiomedical Chromatography, Volume 40, Issue 5, May 2026.
ABSTRACT A precise, robust, and stability‐indicating liquid chromatographic (LC) method coupled with a photodiode array (PDA) detector was developed and validated for the quantitative estimation of rifapentine, an essential therapeutic agent for both active and latent tuberculosis (TB).
Siva Prasad Korikana   +5 more
wiley   +1 more source

Epidemiology and genetic characteristics of Clostridioides difficile isolates in Northwest China [PDF]

open access: yesPeerJ
Clostridioides difficile (C. difficile) is a significant hospital-acquired pathogen that can cause antibiotic-associated diarrhea. In this study, we investigate the epidemiological and genetic characteristics of C.
Yang Li   +5 more
doaj   +2 more sources

Invasive pulmonary aspergillosis and pulmonary tuberculosis in a patient treated with infliximab for Crohn’s disease

open access: yesIDCases, 2019
We report a case of concurrent development of active pulmonary tuberculosis and invasive pulmonary aspergillosis (IPA) in a patient who received therapy with infliximab for Crohn’s disease.
Antonio Riccardo Buonomo   +9 more
doaj   +1 more source

Intracellular Penetration and Effects of Antibiotics on Staphylococcus aureus Inside Human Neutrophils: A Comprehensive Review

open access: yesAntibiotics, 2019
Neutrophils are important assets in defense against invading bacteria like staphylococci. However, (dysfunctioning) neutrophils can also serve as reservoir for pathogens that are able to survive inside the cellular environment. Staphylococcus aureus is a
Suzanne Bongers   +4 more
doaj   +1 more source

Biosynthesis of Rifamycine [PDF]

open access: yesPathologia et Microbiologia, 2008
M, Liersch   +3 more
openaire   +2 more sources

Rifamycins, Alone and in Combination [PDF]

open access: yesCold Spring Harbor Perspectives in Medicine, 2016
Rifamycins inhibit RNA polymerase of most bacterial genera. Rifampicin remains part of combination therapy for treating tuberculosis (TB), and for treating Gram-positive prosthetic joint and valve infections, in which biofilms are prominent. Rifabutin has use for AIDS patients in treating mycobacterial infections TB and Mycobacterium avium complex (MAC)
openaire   +2 more sources

Synthesis of Nucleosidyl Rifamycins as Inhibitors of Human Immunodeficiency Virus Type 1 [PDF]

open access: yes, 1997
In the search for potential nucleoside/non-nucleoside mixed type inhibitors of human immunodeficiency virus type 1 (HIV-1) reverse transcriptase, we synthesized a new set of rifamycin S derivatives, containing AZT connected via its hydroxyl at 5' C ...
A. DI CARO   +10 more
core  

Divergent Rifamycin Susceptibilities of Clostridium difficile Strains in Canada and Italy and Predictive Accuracy of Rifampin Etest for Rifamycin Resistance [PDF]

open access: yes, 2011
We tested the activities of rifampin (RIF) and rifaximin (RFX) against 180 Clostridium difficile clinical isolates selected from Canadian and Italian culture collections.
Mark A. Miller   +4 more
core   +1 more source

Expeditious asymmetric synthesis of a stereoheptad corresponding to the C(19)-C(27)-ansa chain of rifamycins: Formal total synthesis of Rifamycin S [PDF]

open access: yes
In the presence of sulfur dioxide and an acid promoter, (-)-(1E,3Z)-2-methyl-1-((1S)-1-phenyleth- oxy)penta-1,3-dien-3-yl isobutyrate reacts with (Z)-3-(trimethylsilyloxy)-pent-2-ene giving a silyl sulfinate intermediate that undergoes, in the presence ...
Vogel, P., Huang, X. G., Turks, M.
core   +1 more source

Biological activity of a new class of rifamycins Spiro-piperidyl-rifamycins.

open access: yesThe Journal of Antibiotics, 1980
The biological properties of spiro-piperidyl-rifamycins, a new class of rifamycin antibiotics, are described. In these derivatives the positions 3 and 4 have been incorporated into an imidazolyl ring bearing a spiro-piperidyl group N substituted with linear and branched aliphatic chains. The in vitro antibacterial activity against Staphylococcus aureus
A, Sanfilippo   +6 more
openaire   +3 more sources

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