Results 51 to 60 of about 6,382 (203)
Marine Drugs, 2015 An LC-MS-based metabolomics approach was used to characterise the variation in secondary metabolite production due to changes in the salt content of the growth media as well as across different growth periods (incubation times). We used metabolomics as a
Utpal Bose +5 more
doaj +1 more source
Chemistry, 2021 Rifamycins are an extremely important class of antibacterial agents whose action results from the inhibition of DNA-dependent RNA synthesis. A special arrangement of unsubstituted hydroxy groups at C21 and C23, with oxygen atoms at C1 and C8 is essential
Christopher S. Frampton +2 more
doaj +1 more source
Plant, Cell &Environment, Volume 49, Issue 7, Page 3500-3517, July 2026.Abstract Although seed represents an important means of plant pathogen dispersion, the seed–pathogen dialogue remains largely unexplored. A multiomic approach was performed at different seed developmental stages of common bean (Phaseolus vulgaris L.) during asymptomatic colonization by Xanthomonas citri pv.
Armelle Darrasse +6 more
wiley +1 more source
eLife, 2014 Using a combination of genetic, biochemical, and structural approaches, we show that the cyclic-peptide antibiotic GE23077 (GE) binds directly to the bacterial RNA polymerase (RNAP) active-center ‘i’ and ‘i+1’ nucleotide binding sites, preventing the ...
Yu Zhang +16 more
doaj +1 more source
Discovery of pseudobaptigenin synthase in fungal‐infected Trifolium pratense roots
The Plant Journal, Volume 127, Issue 1, July 2026.Significance Statement The discovery of pseudobaptigenin synthase in red clover (CYP76F319), catalyzing the formation of a methylenedioxy bridge to convert calycosin to pseudobaptigenin. The integration of metabolomic and transcriptomic datasets to describe the defense response in red clover roots to hemibiotrophic and necrotrophic fungi.
Lee Marie Raytek +3 more
wiley +1 more source
Rifamycins as inhibitors of retroviral reverse transcriptase from M-MuLV, RAV-2 and HIV-1. [PDF]
, 1992 29 Rifamycins were tested for inhibition of Reverse Transcriptase (RT) as potential anti HIV drugs. Two purified commercial enzymes from M-MuLV and RAV-2 were used. Anti-RT activity was also measured on a crude lysate of HIV-1. The results show that some
P. DI FILIPPO +13 more
core
Frontiers in AntibioticsRifamycin and its derivatives are natural products that belong to the class of antibiotic-active polyketides and have significant therapeutic relevance within the therapy scheme of tuberculosis, a worldwide infectious disease caused by Mycobacterium ...
Moritz Müller +5 more
doaj +1 more source
Mutation position and type of substitution in the β-subunit of the RNA polymerase influence in-vitro activity of rifamycins in rifampicin-resistant Mycobacterium tuberculosis [PDF]
, 2017 Quantitative susceptibility testing for rifampicin, rifabutin and rifapentine of 36 Mycobacterium tuberculosis isolates with known sequences for the gene encoding for the RNA polymerase β-subunit (rpoB)revealed that both mutation position and type of ...
Zürcher, Gabriela +3 more
core
A glimpse of antimicrobial resistance gene diversity in kefir and yoghurt
Scientific Reports, 2020 Antimicrobial resistance (AMR) is a global threat gaining more and more practical significance every year. The main determinants of AMR are the antimicrobial resistance genes (ARGs).
Adrienn Gréta Tóth +11 more
doaj +1 more source
Metabolism‐Based Biomarkers for Rapid Phenotypic Antibiotic Susceptibility Testing
Advanced Science, Volume 13, Issue 33, 15 June 2026.Metabolic differences emerging after antibiotic exposure provide rapid phenotypic signals of susceptibility and resistance. This review summarizes metabolic biomarkers for rapid phenotypic AST, associated with nutrient uptake, respiratory activity, metabolic reprogramming, and enzymatic function. ABSTRACT The accelerating global crisis of antimicrobial
Sha Yu +7 more
wiley +1 more source