Results 1 to 10 of about 60,594 (118)
Bioactive Materials, 2023 Rigidity (or stiffness) of materials and extracellular matrix has proven to be one of the most significant extracellular physicochemical cues that can control diverse cell behaviors, such as contractility, motility, and spreading, and the resultant ...
Jae Hee Park +5 more
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Matrix rigidity regulates cancer cell growth and cellular phenotype.
PLoS ONE, 2010 BackgroundThe mechanical properties of the extracellular matrix have an important role in cell growth and differentiation. However, it is unclear as to what extent cancer cells respond to changes in the mechanical properties (rigidity/stiffness) of the ...
Robert W Tilghman +8 more
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Zyxin Is Involved in Fibroblast Rigidity Sensing and Durotaxis
Frontiers in Cell and Developmental Biology, 2021 Focal adhesions (FAs) are specialized structures that enable cells to sense their extracellular matrix rigidity and transmit these signals to the interior of the cells, bringing about actin cytoskeleton reorganization, FA maturation, and cell migration ...
Ai Kia Yip +14 more
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Differential matrix rigidity response in breast cancer cell lines correlates with the tissue tropism. [PDF]
PLoS ONE, 2009 Metastasis to a variety of distant organs, such as lung, brain, bone, and liver, is a leading cause of mortality in the breast cancer patients. The tissue tropism of breast cancer metastasis has been recognized and studied extensively, but the cellular ...
Ana Kostic +2 more
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The focal adhesion-localized CdGAP regulates matrix rigidity sensing and durotaxis. [PDF]
PLoS ONE, 2014 Motile cells are capable of sensing the stiffness of the surrounding extracellular matrix through integrin-mediated focal adhesions and migrate towards regions of higher rigidity in a process known as durotaxis.
Duncan B Wormer +3 more
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Tumor Suppressor DAPK1 Catalyzes Adhesion Assembly on Rigid but Anoikis on Soft Matrices
Frontiers in Cell and Developmental Biology, 2022 Cancer cells normally grow on soft surfaces due to impaired mechanosensing of the extracellular matrix rigidity. Upon restoration of proper mechanosensing, cancer cells undergo apoptosis on soft surfaces (anoikis) like most normal cells.
Ruifang Qin +5 more
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SEISMIC ANALYSIS OF FRAMES WITH SEMI-RIGID CONNECTIONS IN ACCORDANCE WITH EC8
Facta Universitatis. Series: Architecture and Civil Engineering, 2020 Up to date research has pointed out that most of the structural connections of reinforced concrete (RC) frames, particularly precast ones, behave as semi-rigid.
Dragan Zlatkov +3 more
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Mechanics regulates fate decisions of human embryonic stem cells. [PDF]
PLoS ONE, 2012 Research on human embryonic stem cells (hESCs) has attracted much attention given their great potential for tissue regenerative therapy and fundamental developmental biology studies.
Yubing Sun +5 more
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Formation of Moments Influence Matrix in Frame Based on Graph of its Design Scheme [PDF]
MATEC Web of Conferences, 2021 A procedure is proposed for the automated construction of the bending moments influence matrix in the frame based on the graph of its discrete model. Forming the incidence matrix of the graph characterizing the topological structure of the design scheme ...
Monakhov V.А., Shein А.I.
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Matrix rigidity induces osteolytic gene expression of metastatic breast cancer cells. [PDF]
PLoS ONE, 2010 Nearly 70% of breast cancer patients with advanced disease will develop bone metastases. Once established in bone, tumor cells produce factors that cause changes in normal bone remodeling, such as parathyroid hormone-related protein (PTHrP).
Nazanin S Ruppender +5 more
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