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Materials and extracellular matrix rigidity highlighted in tissue damages and diseases: Implication for biomaterials design and therapeutic targets

open access: yesBioactive Materials, 2023
Rigidity (or stiffness) of materials and extracellular matrix has proven to be one of the most significant extracellular physicochemical cues that can control diverse cell behaviors, such as contractility, motility, and spreading, and the resultant ...
Jae Hee Park   +5 more
doaj   +3 more sources

Uniqueness of Nonnegative Matrix Factorizations by Rigidity Theory [PDF]

open access: yesSIAM Journal on Matrix Analysis and Applications, 2021
Nonnegative matrix factorizations are often encountered in data mining applications where they are used to explain datasets by a small number of parts. For many of these applications it is desirable that there exists a unique nonnegative matrix factorization up to trivial modifications given by scalings and permutations.
Robert Krone, Kaie Kubjas
exaly   +4 more sources

Matrix Rigidity from the Viewpoint of Parameterized Complexity [PDF]

open access: yesSIAM Journal on Discrete Mathematics, 2018
Given an integer \(r>0\), the rigidity of a matrix \(A\) over a field \(\mathbb{F}\), denoted by \(\mathcal{R}^\mathbb{F}_A(r)\), is defined as the minimum Hamming distance between \(A\) and a matrix of rank at most \(r\); in other words, the minimum number of entries in \(A\) which one has to change in order to reduce its rank to at most \(r\).
Saket Saurabh   +2 more
exaly   +4 more sources

Matrix Rigidity and the Ill-Posedness of Robust PCA and Matrix Completion [PDF]

open access: yesSIAM Journal on Mathematics of Data Science, 2019
19 pages, 3 ...
Jared Tanner, Simon Vary
exaly   +5 more sources

Targeting the Akt–EphA2 axis and cell–cell adhesion enhances anoikis sensitivity in cancer cells [PDF]

open access: yesScientific Reports
Rigidity sensing enables cells to respond to extracellular matrix stiffness and governs survival and apoptotic decisions. Tropomyosin 2.1 (Tpm2.1), a key actin-binding protein, is frequently downregulated in cancer.
Anat Galis Vivante   +3 more
doaj   +2 more sources

On the dual rigidity matrix

open access: yesLinear Algebra and Its Applications, 2008
zbMATH Open Web Interface contents unavailable due to conflicting licenses.
A Y Alfakih
exaly   +2 more sources

Matrix rigidity

open access: yesLinear Algebra and Its Applications, 2000
Matrix rigidity has been introduced by \textit{L. G. Valiant} [Lect. Notes Comput. Sci. 53, 162-176 (1977; Zbl 0384.68046)] in connection with the complexity theory, namely that of proving nontrivial lower bounds on the length of computations. Valiant suggested that nonlinear lower bounds on the length of programs can be proved by constructing matrices
exaly   +3 more sources

Elucidating the Role of Matrix Porosity and Rigidity in Glioblastoma Type IV Progression

open access: yesApplied Sciences, 2020
The highly infiltrating nature of glioma cells is the major cause for the poor prognosis of brain malignancies. Motility, proliferation, and gene expression of cells in natural and synthetic gels have been analyzed by several authors, yet quantitative ...
Rui C. Pereira   +5 more
doaj   +3 more sources

Zyxin Is Involved in Fibroblast Rigidity Sensing and Durotaxis

open access: yesFrontiers in Cell and Developmental Biology, 2021
Focal adhesions (FAs) are specialized structures that enable cells to sense their extracellular matrix rigidity and transmit these signals to the interior of the cells, bringing about actin cytoskeleton reorganization, FA maturation, and cell migration ...
Ai Kia Yip   +14 more
doaj   +1 more source

Differential matrix rigidity response in breast cancer cell lines correlates with the tissue tropism. [PDF]

open access: yesPLoS ONE, 2009
Metastasis to a variety of distant organs, such as lung, brain, bone, and liver, is a leading cause of mortality in the breast cancer patients. The tissue tropism of breast cancer metastasis has been recognized and studied extensively, but the cellular ...
Ana Kostic   +2 more
doaj   +1 more source

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