Materials and extracellular matrix rigidity highlighted in tissue damages and diseases: Implication for biomaterials design and therapeutic targets [PDF]
Bioactive Materials, 2023 Rigidity (or stiffness) of materials and extracellular matrix has proven to be one of the most significant extracellular physicochemical cues that can control diverse cell behaviors, such as contractility, motility, and spreading, and the resultant ...
Jae Hee Park +5 more
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Matrix‐Rigidity Cooperates With Biochemical Cues in M2 Macrophage Activation Through Increased Nuclear Deformation and Chromatin Accessibility [PDF]
Advanced ScienceMacrophages encounter a myriad of biochemical and mechanical stimuli across various tissues and pathological contexts. Notably, matrix rigidity has emerged as a pivotal regulator of macrophage activation through mechanotransduction.
Seung Jae Shin +11 more
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Cellular mechanosignaling for sensing and transducing matrix rigidity. [PDF]
Curr Opin Cell Biol, 2023 The mechanisms by which cells sense their mechanical environment and transduce the signal through focal adhesions and signaling pathways to the nucleus is an area of key focus for the field of mechanobiology. In the past two years, there has been expansion of our knowledge of commonly studied pathways, such as YAP/TAZ, FAK/Src, RhoA/ROCK, and Piezo1 ...
Young KM, Reinhart-King CA.
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Extracellular matrix rigidity controls breast cancer metastasis via TYK2-mediated mechanotransduction [PDF]
Nature CommunicationsMechanical cues from the extracellular matrix (ECM) regulate various cellular processes. In breast cancer, increased tumor stiffness is associated with elevated metastasis risks and poor survival.
Zhimin Hu +10 more
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The focal adhesion-localized CdGAP regulates matrix rigidity sensing and durotaxis. [PDF]
PLoS ONE, 2014 Motile cells are capable of sensing the stiffness of the surrounding extracellular matrix through integrin-mediated focal adhesions and migrate towards regions of higher rigidity in a process known as durotaxis.
Duncan B Wormer +3 more
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Uniqueness of Nonnegative Matrix Factorizations by Rigidity Theory [PDF]
SIAM Journal on Matrix Analysis and Applications, 2021 Nonnegative matrix factorizations are often encountered in data mining applications where they are used to explain datasets by a small number of parts. For many of these applications it is desirable that there exists a unique nonnegative matrix factorization up to trivial modifications given by scalings and permutations.
Robert Krone, Kaie Kubjas
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Matrix Rigidity from the Viewpoint of Parameterized Complexity [PDF]
SIAM Journal on Discrete Mathematics, 2018 Given an integer \(r>0\), the rigidity of a matrix \(A\) over a field \(\mathbb{F}\), denoted by \(\mathcal{R}^\mathbb{F}_A(r)\), is defined as the minimum Hamming distance between \(A\) and a matrix of rank at most \(r\); in other words, the minimum number of entries in \(A\) which one has to change in order to reduce its rank to at most \(r\).
Saket Saurabh +2 more
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Matrix Rigidity and the Ill-Posedness of Robust PCA and Matrix Completion [PDF]
SIAM Journal on Mathematics of Data Science, 2019 19 pages, 3 ...
Jared Tanner, Simon Vary
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Matrix rigidity-modulated cardiovascular organoid formation from embryoid bodies. [PDF]
PLoS ONE, 2014 Stem cell clusters, such as embryoid bodies (EBs) derived from embryonic stem cells, are extensively studied for creation of multicellular clusters and complex functional tissues.
Artem Shkumatov +2 more
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Standard Loading Profile in Matrix Rigidity Sensing. [PDF]
Biophys J, 2018 It is important to learn features of locally applied forces by cells during matrix rigidity sensing, since the function of mechanosensing proteins would be affected by force magnitude, loading velocity, or even loading history. Here, we investigate a rigidity-sensing apparatus consisting of a contractile unit on matrices.
Dong C, Chen X, Chen B.
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