Results 81 to 90 of about 1,031,550 (305)
ChemistryOpenNovel tetrahydroisoquinoline and piperidine derivatives were selectively synthesized from substituted indenes or cyclopentenes. The process starts with an oxidative cleavage of the ring olefin bond, which gives reactive diformyl intermediates.
Anas Semghouli +4 more
doaj +1 more source
FEBS Letters, EarlyView.Fluorescent probes allow dynamic visualization of phosphoinositides in living cells (left), whereas mass spectrometry provides high‐sensitivity, isomer‐resolved quantitation (right). Their synergistic use captures complementary aspects of lipid signaling. This review illustrates how these approaches reveal the spatiotemporal regulation and quantitative
Hiroaki Kajiho +3 more
wiley +1 more source
The synthesis and ring-opening polymerisation of functionalised chiral O-carboxyanhydrides and cyclic carbonates [PDF]
This thesis presents the synthesis of two novel O-carboxyanhydrides derived from L-malic acid bearing 2,2,2-trichloroethyl- and 2-nitrobenzyl esters, followed by investigation of their ring-opening polymerisation to furnish chiral, functionalised poly ...
Bennison, Michael J.
core
Ring-Opening Olefin Metathesis of Twisted Amides: Activation of Amide Bonds by CC Cleavage
, 2019 Selective CC bond cleavage in twisted amides by ring-opening olefin metathesis (ROM) was accomplished. The reaction represents the third mechanism for ring opening of nonplanar amide bonds discovered.
Roger Lalancette +7 more
core +1 more source
Nature Communications, 2019 Ring-opening reaction via selective cleavage of C–C bond is a powerful strategy to increase molecular complexity. Here the authors present the facile synthesis of chiral 1,5- and 1,6-dinitriles via the radical-mediated ring-opening and enantioselective ...
Tao Wang +6 more
doaj +1 more source
Phosphatidylinositol 4‐kinase as a target of pathogens—friend or foe?
FEBS Letters, EarlyView.This graphical summary illustrates the roles of phosphatidylinositol 4‐kinases (PI4Ks). PI4Ks regulate key cellular processes and can be hijacked by pathogens, such as viruses, bacteria and parasites, to support their intracellular replication. Their dual role as essential host enzymes and pathogen cofactors makes them promising drug targets.
Ana C. Mendes +3 more
wiley +1 more source
Protein pyrophosphorylation by inositol pyrophosphates — detection, function, and regulation
FEBS Letters, EarlyView.Protein pyrophosphorylation is an unusual signaling mechanism that was discovered two decades ago. It can be driven by inositol pyrophosphate messengers and influences various cellular processes. Herein, we summarize the research progress and challenges of this field, covering pathways found to be regulated by this posttranslational modification as ...
Sarah Lampe +3 more
wiley +1 more source
Ring-Opening Hydroarylation of Monosubstituted Cyclopropanes Enabled by Hexafluoroisopropanol
, 2018 Ring-opening hydroarylation of cyclopropanes is typically limited to substrates bearing a donor-acceptor motif. Here, the transformation is achieved for monosubstituted cyclopropanes by using catalytic Brønsted acid in hexafluoroisopropanol (HFIP ...
Christopher Rowley +11 more
core +1 more source
, 2016 Ring-Opening Protonolysis of Strained Silicon-Containing Rings: A New Approach to Ions with Silylium ...
Alan J. Lough (1306146) +3 more
core +2 more sources
Two-step ATP-driven opening of cohesin head
Scientific Reports, 2017 The cohesin ring is a protein complex composed of four core subunits: Smc1A, Smc3, Rad21 and Stag1/2. It is involved in chromosome segregation, DNA repair, chromatin organization and transcription regulation.
Íñigo Marcos-Alcalde +10 more
doaj +1 more source