Results 161 to 170 of about 2,301,251 (349)

Recent Progress in the Chemistry of Ring‐Fused Azulenes: Synthesis, Reactivity and Properties [PDF]

Taku Shoji, Shunji Ito
openalex   +1 more source

Overexpression of CDT1 inhibits cell cycle progression at S phase by interacting with the mini‐chromosome maintenance complex and causes DNA damage

FEBS Open Bio, EarlyView.
CDT1 is an essential protein for DNA replication licensing that loads the MCM complex, the eukaryotic replicative DNA helicase, onto replication origins. Overexpression of CDT1 induces cell cycle arrest at the S phase. Here we showed CDT1 inhibits the progression of replication forks by interacting with the MCM complex, leading to the stalling and ...
Takashi Tsuyama, Nonoka Takayama, Rina Tanaka, Yuuki Arai, Yohko Yamaguchi, Yuko Nawata, Yutaro Azuma, Shusuke Tada   +7 more
wiley   +1 more source

Health Correlates of Extended Longevity in Captive Ring-Tailed Lemurs (Lemur catta). [PDF]

Am J Primatol
Mustill RL, Ellsaesser LN, Williams CV, Petersdorf M, Greene LK.   +4 more
europepmc   +1 more source

Chemistry of Germanium-Characteristics and Similarity as a Group 14 Element. Photosensitized (Electron Transfer) Reaction of Peralkyltrisilagermacyclobutanes; Ring-Opening Chlorination.

, 1994
Hideo Suzuki, Syuji Takahashi, Yoshikuni ODAKA, Kazutoshi Okabe, Hamao Watanabe   +4 more
openalex   +2 more sources

A general model for analysis of linear and hyperbolic enzyme inhibition mechanisms

FEBS Open Bio, EarlyView.
We developed a general enzyme kinetic model that integrates these six basic inhibition mechanism onto a single one. From this model, we deduced a general enzyme kinetic equation that through modulation of simple parameters, γ (the relative inhibitor affinity for two binding sites) and β (the reactivity of the enzyme–substrate–inhibitor complex), is ...
Rafael S. Chagas, Sandro R. Marana
wiley   +1 more source

Toward the Observation of Dimagnesocene. [PDF]

ACS Omega
Briggs CG, Goodlett SM, Schaefer HF.
europepmc   +1 more source

Effects of Additional Ring-Fusion Site on Dual Reactivity Based Dynamic Covalent Chemistry

Fa Zhong, Xiaojun Wan, Lei You
openalex   +1 more source

Homologous expression and purification of human HAX‐1 for structural studies

FEBS Open Bio, EarlyView.
This research protocol provides detailed instructions for cloning, expressing, and purifying large quantities of the intrinsically disordered human HAX‐1 protein, N‐terminally fused to a cleavable superfolder GFP, from mammalian cells. HAX‐1 is predicted to undergo posttranslational modifications and to interact with membranes, various cellular ...
Mariana Grieben
wiley   +1 more source

Bridging mechanism and design: modern medicinal chemistry approaches to thymidylate synthase inhibitors. [PDF]

RSC Adv
Al-Karmalawy AA, Eissa ME, Yousef TA, Al Khatib AO, Hawas SS.   +4 more
europepmc   +1 more source

Thrombolytic proteins profiling: High‐throughput activity, selectivity, and resistance assays

FEBS Open Bio, EarlyView.
We present optimized biochemical protocols for evaluating thrombolytic proteins, enabling rapid and robust screening of enzymatic activity, inhibition resistance, and fibrin affinity, stimulation, and selectivity. The outcome translates to key clinical indicators such as biological half‐life and bleeding risk. These assays streamline the development of
Martin Toul, Alan Strunga, Jiri Damborsky, Zbynek Prokop   +3 more
wiley   +1 more source