Results 71 to 80 of about 3,211,194 (278)

Ringing medicinal chemistry: The importance of 3-membered rings in drug discovery

Bioorganic & Medicinal Chemistry
Scaffold-based drug design has become increasingly prominent in the pharmaceutical field due to the systematic and effective approach through which it facilitates the development of novel drugs. The identification of key scaffolds provides medicinal chemists with a fundamental framework for subsequent research.
Sahani Sandalima, Uthumange, Angie Jun Hui, Liew, Xavier Wezen, Chee, Keng Yoon, Yeong   +3 more
openaire   +2 more sources

Liver organoids: modelling complexity in homeostasis and disease

FEBS Letters, EarlyView.
Studying liver in vitro has been challenging because simple 2D cell cultures fail to capture liver's cellular and architectural complexity. To bridge this gap, scientists increasingly use organoids, 3D liver models which better mimic liver composition and function. This review examines recent advances in liver organoid complexity and realism, discusses
Anna M. Dowbaj, Meritxell Huch
wiley   +1 more source

Unveiling SEI Formation Dynamics of PEO: LiTFSI with Lithium Metal: An In Situ Approach Combining SIMS, XPS, and CTTA

Advanced Materials Interfaces
Electrolyte interfaces with freshly plated lithium metal are crucial for the development of reservoir‐free all‐solid‐state batteries (ASSBs).
Timo Weintraut, Alexander Weiss, Sebastian Leonard Benz, Burak Aktekin, Joachim Sann, Anja Henss   +5 more
doaj   +1 more source

Ligand‐dependent transcriptional heterogeneity in cell cycle gene expression delays G1/S entry

FEBS Letters, EarlyView.
EGF and HRG induce distinct G1/S progression programs in ErbB2‐amplified BT474 breast cancer cells. Despite activating the potent ErbB2–ErbB3 heterodimer, HRG does not accelerate cell‐cycle entry. Instead, EGF promotes earlier restriction‐point passage via ERK–FOS signaling, whereas HRG activates the AKT–MYC axis, driving transcriptional heterogeneity ...
Ririn Rahmala Febri, Ayaka Nagasato‐Ichikawa, Keita Iida, Shuhei Kimura, Akira Imamoto, Mariko Okada   +5 more
wiley   +1 more source

Emerging experimental and computational methods for studying redox‐regulated structural transitions

FEBS Letters, EarlyView.
Redox reactions can reshape proteins and alter how they behave in cells, with important consequences for health and disease. This review explores emerging experimental and computational approaches for discovering these redox‐sensitive protein switches, revealing their structural effects, and predicting their behavior, opening new opportunities to ...
Tasneem Rass, Dana Reichmann, Gábor Erdős   +2 more
wiley   +1 more source

Time‐of‐Flight Secondary Ion Mass Spectrometry Revealing the Organocatalyst Distribution in Functionalized Silica Monoliths

ChemistryOpen
Hierarchically porous monolithic silica shows promise as a carrier material for immobilized organocatalysts. Conventional analysis usually includes physisorption, infrared spectroscopy and elemental analysis, among others, to elucidate the pore space and
Raoul D. Brand, Dr. Julia S. Schulze, Dr. Anja Henss, Prof. Bernd M. Smarsly   +3 more
doaj   +1 more source

Exploring Catalysis inside Self-assembled Supramolecular Containers

CHIMIA, 2016
Our group is interested in applying supramolecular host systems as catalysts for challenging transformations. Although a variety of supramolecular containers has been described in literature, their use as reaction chambers is still underexplored.
Lorenzo Catti, Thomas M. Bräuer, Qi Zhang, Konrad Tiefenbacher   +3 more
doaj   +1 more source

Starazo triple switches – synthesis of unsymmetrical 1,3,5-tris(arylazo)benzenes

Beilstein Journal of Organic Chemistry, 2020
Multistate switches allow to drastically increase the information storage capacity and complexity of smart materials. In this context, unsymmetrical 1,3,5-tris(arylazo)benzenes – ‘starazos’ – which merge three photoswitches on one benzene ring, were ...
Andreas H. Heindl, Hermann A. Wegner
doaj   +1 more source

Synergistic perspectives—How single‐molecule biophysics complement biochemical understanding

FEBS Letters, EarlyView.
In this review, we discuss how ensemble biochemistry and single‐molecule approaches are complementary, outline commonly used single‐molecule techniques, and illustrate their relevance through two representative case studies: chromatin organization by SMC complexes and pathway choice during DNA double‐strand break repair.
Sara De Bragança, Eline L. Jansen, Jorine M. Eeftens   +2 more
wiley   +1 more source

Density of Tree-Ring Grids in Western North America

, 1982
The separating distance over which tree-ring chronologies are significantly correlated is investigated. Any chronology occuring within a radius of 161 km of another is estimated to contain at least half of the common variance occurring at zero separating
Cropper, John Philip, Fritts, Harold C.
core   +4 more sources