Results 121 to 130 of about 108,684 (302)
Ring Expansions of Oxetanes [PDF]
Chinese Journal of Organic Chemistry, 2021 Jiaxi Xu, Wenhao Yuan
openaire +1 more source
FEBS Open Bio, EarlyView.Pharmacological inhibition of PERK in a DEN‐induced mouse model of liver cancer does not reduce tumor burden but alters cellular stress signaling. Despite blocking PERK activity, downstream stress responses, including CHOP expression, remain active, suggesting compensatory mechanisms within the unfolded protein response that may influence tumor ...
Ada Lerma‐Clavero +5 more
wiley +1 more source
Change of Connectivity on Catenane Ring: Ring Expansion by Annulation−Ring Scission Sequence
, 2016 Ring expansion of a catenane without destruction of the interlocked structure was attained by Diels−Alder reaction followed by ozonolysis. Annulation by Diels−Alder reaction introduced a C4 fragment onto the ring, and the ozonolysis scissored the ...
Nobuhiro Watanabe (85498) +2 more
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FEBS Open Bio, EarlyView.Early‐life exposure to a high‐fat diet altered intact Achilles tendons in rat offspring, making them thinner, stiffer, and molecularly distinct even without injury. These findings suggest that developmental high‐fat diet exposure may impair tendon quality and increase susceptibility to mechanical overload or tendon injury later in life.
Heyong Yin +3 more
wiley +1 more source
FEBS Open Bio, EarlyView.UiO‐66(Zr) metal–organic frameworks are chemically stable, biocompatible, and highly tunable nanomaterials. Their modular structure enables controlled drug delivery, multimodal bioimaging, and light‐activated photodynamic therapy, supporting integrated diagnostic and therapeutic (theranostic) applications in cancer and biomedical research.
Veronika Huntošová +2 more
wiley +1 more source
FEBS Open Bio, EarlyView.The dual roles of CC and CXC chemokines in distinguishing active, latent, and subclinical tuberculosis were reviewed, along with an evaluation of their potential as diagnostic biomarkers and therapeutic targets to advance precision medicine in tuberculosis management. The graphical abstract was generated with AI assistance (Gemini 3.0).
Xuying Yin, Dangsheng Xiao, Jiezuan Yang
wiley +1 more source
Medium Ring Ethers by Ring Expansion−Ring Contraction: Synthesis of Lauthisan
, 2016 A new general method for the construction of medium ring ethers has been developed. This involves the ring expansion of halo-O,S-acetals followed by a Ramburg−Bäcklund ring contraction reaction with concomitant extrusion of the sulfur atom.
Mark J. Coster (1846177) +1 more
core +1 more source
Directed evolution of enzymes at the crossroads of tradition and innovation
FEBS Open Bio, EarlyView.An iterative cycle of data‐driven enzyme optimization comprising four stages: genetic diversification of a template enzyme, expression of protein variants, high‐throughput evaluation, and machine‐learning‐guided redesign of the next variant library.
Maria Tomkova +2 more
wiley +1 more source
The mechanism of the enzymatic ring expansion of penicillin N to deacetoxycephalosporin C
, 1988 The order of events in the Deacetoxycephalosporin C/Deacetylcephalosporrn C Synthetase (DAOC/DAC Synthetase) catalysed ring expansion of penicillin N to deacetoxycephalosporin C has been investigated by the use of labelled/unlabelled penicillin N mixed ...
Crouch, Nicholas., Crouch, Nicholas P.
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Construction Land Expansion and the Influence Mechanism around Hainan Roundabout Railway Stations
Redai diliHigh-Speed Rail (HSR) stations can influence the expansion of the surrounding construction land. However, relevant studies face three main limitations: influence scope estimation lacking a theoretical foundation, less focus on whether the impacts of HSR ...
Xiong Changsheng +4 more
doaj +1 more source