Results 51 to 60 of about 108,684 (302)

Protein pyrophosphorylation by inositol pyrophosphates — detection, function, and regulation

FEBS Letters, EarlyView.
Protein pyrophosphorylation is an unusual signaling mechanism that was discovered two decades ago. It can be driven by inositol pyrophosphate messengers and influences various cellular processes. Herein, we summarize the research progress and challenges of this field, covering pathways found to be regulated by this posttranslational modification as ...
Sarah Lampe, Tanmay Kumar Mohanty, Rashna Bhandari, Dorothea Fiedler   +3 more
wiley   +1 more source

Fluorination Homologation of Biorenewable Synthon Cyrene

Molbank
A one-carbon difluorocyclopropanation/ring-expansion has been developed for the chiral synthon Cyrene, which is obtained via cellulose pyrolysis. The ring-enlargement was achieved by converting Cyrene (dihydrolevoglucosenone) into an enamine, reacting it
Johannes Puschnig, Ben W. Greatrex
doaj   +1 more source

Structural insights into an engineered feruloyl esterase with improved MHET degrading properties

FEBS Letters, EarlyView.
A feruloyl esterase was engineered to mimic key features of MHETase, enhancing the degradation of PET oligomers. Structural and computational analysis reveal how a point mutation stabilizes the active site and reshapes the binding cleft, expading substrate scope.
Panagiota Karampa, Konstantinos Makryniotis, Theofani‐Iosifina Sousani, Evangelos Topakas, Vangelis Daskalakis, Maria Dimarogona   +5 more
wiley   +1 more source

Efficient Identity-based Encryption Scheme over Ideal Lattice [PDF]

Jisuanji gongcheng, 2016
Recently,Identity-based Encryption(IBE) scheme based on lattices becomes one of the focuses of cryptographic research.But the IBE scheme based on standard lattice have large key size and high ciphertext expansion rate.So based on ideal lattices,this ...
WEI Lihao,AI Jieqing,LIU Shenghan
doaj   +1 more source

Gut microbiome and aging—A dynamic interplay of microbes, metabolites, and the immune system

FEBS Letters, EarlyView.
Age‐dependent shifts in microbial communities engender shifts in microbial metabolite profiles. These in turn drive shifts in barrier surface permeability of the gut and brain and induce immune activation. When paired with preexisting age‐related chronic inflammation this increases the risk of neuroinflammation and neurodegenerative diseases.
Aaron Mehl, Eran Blacher
wiley   +1 more source

The ubiquitin ligase RNF115 is required for the clearance of damaged lysosomes

FEBS Letters, EarlyView.
Upon lysosomal rupture, an E3 ubiquitin ligase RNF115 translocates from the cytosol to the damaged lysosomal membrane. Moreover, RNF115 depletion impairs the clearance of damaged lysosomes, identifying it as a key regulator of lysosomal quality control.
Sae Nakanaga, Toshiki Takahashi, Akiko Kuma, Hiroyuki Kawahara   +3 more
wiley   +1 more source

Synthetic applications of gold-catalyzed ring expansions

Beilstein Journal of Organic Chemistry, 2011
The development of new methodologies catalyzed by late transition metals involving cycloisomerizations of strained rings can open new venues for the synthesis of structurally complex molecules with interesting biological activities.
David Garayalde, Cristina Nevado
doaj   +1 more source

The human gut microbiome across the life course

FEBS Letters, EarlyView.
Despite significant individual variation and continuous change throughout life, the human gut microbiome follows some life stage‐specific trends. This article provides a brief overview of how gut microbiome composition shifts across different phases of life. Created in BioRender. Özkurt, E. (2026) https://BioRender.com/8q4nrnc.
Alise J. Ponsero, Basak Bahcivanci, Antonietta Hayhoe, Animesh Acharjee, Ezgi Özkurt   +4 more
wiley   +1 more source

The C-Ring Problem of Sterol Biosynthesis:  TiCl₄-Induced Rearrangement into the Anti-Markovnikov Cation Corresponding to the C-Ring

, 2016
Cation 9, generated by the reaction of diol 8 and BF3·Et2O, SnCl4, Sc(OTf)3, FeCl3, TiF4, or CF3SO3H, leads to a hydride shift, providing cation 11, which corresponds to the initiation of backbone rearrangement.
Mugio Nishizawa (2004031), Yoshihiro Iwamoto (3062490), Takumichi Sugihara (2730133), Hiroshi Imagawa (1596826), Hiroko Takao (2730136)   +4 more
core   +2 more sources

Asymmetric [3 + 2] Cycloaddition to Access 3‐Pyrrolines and Their Switchable Transformations to Nine‐Membered Cyclic Sulfamidates and 2H‐Pyrroles

Advanced Science
Herein, Pd‐catalyzed asymmetric [3 + 2] cycloaddition and olefin isomerization is reported to afford chiral 3‐pyrrolines using cyano‐TMM (trimethylenemethane) and cyclic sulfamidate imines.
Seoung‐Mi Choi, Jong‐Un Park, Ju Hyun Kim   +2 more
doaj   +1 more source