Results 91 to 100 of about 19,353 (245)

RIPK3—a predictive marker for personalized immunotherapy? [PDF]

OncoImmunology, 2016
Cancer immunotherapy is an attractive therapeutic option but it is currently unclear which patient may benefit from such approaches. Using the model of cervical cancer, we have demonstrated that PolyIC-driven immunogenicity strictly depends on the necroptosis regulator RIPK3 in the neoplastic cells.
openaire   +3 more sources

Leishmania braziliensis Subverts Necroptosis by Modulating RIPK3 Expression [PDF]

Frontiers in Microbiology, 2018
Leishmania braziliensis infection causes skin ulcers, typically found in localized cutaneous leishmaniasis (LCL). This tissue pathology associates with different modalities of cell necrosis, which are subverted by the parasite as a survival strategy.
Nivea F. Luz, Ricardo Khouri, Ricardo Khouri, Johan Van Weyenbergh, Johan Van Weyenbergh, Dalila L. Zanette, Dalila L. Zanette, Paloma P. Fiuza, Almerio Noronha, Aldina Barral, Aldina Barral, Viviane S. Boaventura, Viviane S. Boaventura, Deboraci B. Prates, Deboraci B. Prates, Francis Ka-Ming Chan, Bruno B. Andrade, Bruno B. Andrade, Bruno B. Andrade, Valeria M. Borges, Valeria M. Borges   +20 more
openaire   +4 more sources

Akt and mTOR mediate programmed necrosis in neurons [PDF]

, 2014
Necroptosis is a newly described form of regulated necrosis that contributes to neuronal death in experimental models of stroke and brain trauma. Although much work has been done elucidating initiating mechanisms, signaling events governing necroptosis ...
Degterev, A, Golinski, J, Jung, J E, Liang, M, Liu, Q, Lo, E H, Qiu, J, van Leyen, K, Whalen, M J, You, Z   +9 more
core   +1 more source

Role of the caspase-8/RIPK3 axis in Alzheimer’s disease pathogenesis and Aβ-induced NLRP3 inflammasome activation

JCI Insight, 2023
The molecular mediators of cell death and inflammation in Alzheimer’s disease (AD) have yet to be fully elucidated. Caspase-8 is a critical regulator of several cell death and inflammatory pathways; however, its role in AD pathogenesis has not yet been ...
Sushanth Kumar, Sakar Budhathoki, C. Oliveira, August D. Kahle, O. Calhan, J. Lukens, C. Deppmann   +6 more
semanticscholar   +1 more source

Respiratory Syncytial Virus (RSV): A Comprehensive Overview From Basic Biology to Clinical Prevention and Control

Medicinal Research Reviews, EarlyView.
ABSTRACT Respiratory syncytial virus (RSV) is a common virus that causes respiratory infections, posing a serious threat, particularly to infants, the elderly, and individuals with compromised immune systems. As the leading cause of lower respiratory tract infections (LRTIs) in infants, RSV is responsible for millions of cases worldwide each year.
Jie Shi, Xiya Huang, Chunjun Ye, Yishan Lu, Yanyan Liu, Yuquan Wei, Xiawei Wei   +6 more
wiley   +1 more source

Gut microbiota facilitates dietary heme-induced epithelial hyperproliferation by opening the mucus barrier in colon [PDF]

, 2015
Colorectal cancer risk is associated with diets high in red meat. Heme, the pigment of red meat, induces cytotoxicity of colonic contents and elicits epithelial damage and compensatory hyperproliferation, leading to hyperplasia.
Clara Belzer, Giovannucci, Guido J. Hooiveld, Jan Dekker, Lapré, McGarr, Michael Müller, Michiel Kleerebezem, Noortje Ijssennagger, Roelof van der Meer, Saskia W. C. van Mil, Sesink, Sheffner, van Klinken   +13 more
core   +2 more sources

Impact of Mlkl or Ripk3 deletion on age-associated liver inflammation, metabolic health, and lifespan

GeroScience
Chronic, low-grade inflammation is a hallmark of aging and various age-related diseases, including metabolic dysfunction-associated steatotic liver disease (MASLD).
Sabira Mohammed, Phoebe Ohene-Marfo, Chao Jiang, Zongkai Peng, Nidheesh Thadathil, Albert L Tran, Evan H Nicklas, S. Bhaskaran, Dawei Wang, Ramasamy Selvarani, Amit Singh, Zhibo Yang, Nagib Ahsan, S. S. Deepa   +13 more
semanticscholar   +1 more source

6‐Shogaol Attenuates Doxorubicin‐Induced Cardiac and Skeletal Muscle Atrophy by Inhibiting E3 Ubiquitin Ligases and Necroptosis

Phytotherapy Research, EarlyView.
Doxorubicin induces cardiac and skeletal muscle atrophy by upregulating E3 ubiquitin ligases, inhibiting myogenic regulatory factors, and activating necroptosis. Cardiac atrophy can further exacerbate cardiotoxicity. 6‐Shogaol negatively regulates these processes and attenuates doxorubicin‐induced cardiac and skeletal muscle atrophy.
Xipeng Sun, Yaxian Wang, Quanjun Yang, Bo Xin, Jinlu Huang, Cheng Guo   +5 more
wiley   +1 more source

Receptor-Interacting Protein Kinase 3 Deficiency Delays Cutaneous Wound Healing. [PDF]

PLoS ONE, 2015
Wound healing consists of a complex, dynamic and overlapping process involving inflammation, proliferation and tissue remodeling. A better understanding of wound healing process at the molecular level is needed for the development of novel therapeutic ...
Andrew Godwin, Archna Sharma, Weng-Lang Yang, Zhimin Wang, Jeffrey Nicastro, Gene F Coppa, Ping Wang   +6 more
doaj   +1 more source

PLK1-mediated S369 phosphorylation of RIPK3 during G2 and M phases enables its ripoptosome incorporation and activity

iScience, 2021
Summary: Receptor-interacting protein kinase 3 executes a form of regulated necrosis called necroptosis. Upon induction of an altered conformation by chemical inhibitors or via mutations in its kinase site, RIPK3 associates with a multiprotein complex ...
Kartik Gupta, Bo Liu
doaj   +1 more source