Results 111 to 120 of about 17,129 (242)

Machine Learning‐Based Integrative Analysis Identifies SUMOylation‐Related Genes Underlying the Immune Heterogeneity of Sepsis

IET Systems Biology, Volume 20, Issue 1, January/December 2026.
This study identified an eight‐gene signature associated with SUMOylation using machine learning and bioinformatics approaches, which effectively stratifies sepsis patients into two distinct subtypes: immune‐suppressive and hyper‐inflammatory. This discovery not only reveals the critical role of SUMOylation in sepsis heterogeneity but also provides new
Zeqian Li, Jian Yang, Jiale Dong, Zhaofei Ye, Chengxiang Li, Yang Hu, Han Ren, Shiran Li, Zhili Ji   +8 more
wiley   +1 more source

Therapeutic contribution of melatonin to the treatment of septic cardiomyopathy: A novel mechanism linking Ripk3-modified mitochondrial performance and endoplasmic reticulum function

Redox Biology, 2019
The basic pathophysiological mechanisms underlying septic cardiomyopathy have not yet been completely clarified. Disease-specific treatments are lacking, and care is still based on supportive modalities.
Jiankai Zhong, Ying Tan, Jianhua Lu, Jichen Liu, Xiaochan Xiao, Pinji Zhu, Sainan Chen, Sulin Zheng, Yuying Chen, Yunzhao Hu, Zhigang Guo   +10 more
doaj   +1 more source

TRADD Mediates RIPK1-Independent Necroptosis Induced by Tumor Necrosis Factor

Frontiers in Cell and Developmental Biology, 2020
As a programmed necrotic cell death, necroptosis has the intrinsic initiators, including receptor-interacting serine/threonine-protein kinase 1 (RIPK1), RIPK3 and mixed-lineage kinase domain-like protein (MLKL), which combine to form necroptotic ...
Lili Wang, Xixi Chang, Jinli Feng, Jiyun Yu, Jiyun Yu, Guozhu Chen   +5 more
doaj   +1 more source

Necroptosis-driving genes RIPK1, RIPK3 and MLKL-p are associated with intratumoral CD3⁺ and CD8⁺ T cell density and predict prognosis in hepatocellular carcinoma [PDF]

, 2022
Lorenzo Nicolè, Tiziana Sanavia, Rocco Cappellesso, Valeria Maffeis, Jun Akiba, Akihiko Kawahara, Yoshiki Naito, Claudia Maria Radu, Paolo Simioni, Davide Serafin, Giuliana Cortese, Maria Guido, Giacomo Zanus, Hirohisa Yano, Ambrogio Fassina   +14 more
openalex   +1 more source

Ubiquitin-mediated regulation of RIPK1 kinase activity independent of IKK and MK2 [PDF]

, 2018
Tumor necrosis factor (TNF) can drive inflammation, cell survival, and death. While ubiquitylation-, phosphorylation-, and nuclear factor kappa B (NF-kappa B)-dependent checkpoints suppress the cytotoxic potential of TNF, it remains unclear whether ...
Annibaldi, Alessandro, Bertin, John, Bianchi, Katiuscia, Choi, Sze Men, Elliott, Paul R, John, Sidonie Wicky, Komander, David, Liccardi, Gianmaria, Meier, Pascal, Ruan, Jianbin, Silke, John, Swatek, Kirby N, Van Coillie, Samya, Vanden Berghe, Tom, Vandenabeele, Peter, Wu, Hao   +15 more
core   +2 more sources

β‐Hydroxybutyrate Acts as an Exercise Mimetic to Protect the Aging Liver

Aging Cell, Volume 25, Issue 1, January 2026.
β‐hydroxybutyrate (β‐HB) acts as an exercise mimetic to protect the aging liver. In aged models, exercise‐induced β‐HB delays liver aging by reversing macrophage senescence, blocking mtDNA/cGAS‐STING‐driven inflammation, and alleviating hepatocyte lipid deposition/PANoptosis.
Ke Li, Lian Wang, Danlin Zhu, Wenhong Wang, Yifan Guo, Haoyang Gao, Muge Zhou, Weihua Xiao   +7 more
wiley   +1 more source

The Inflammatory Signal Adaptor RIPK3: Functions Beyond Necroptosis [PDF]

, 2017
Receptor interacting protein kinase 3 (RIPK3) is an essential serine/threonine kinase for necroptosis, a type of regulated necrosis. A variety of stimuli can cause RIPK3 activation through phosphorylation. Activated RIPK3 in turn phosphorylates and activates the downstream necroptosis executioner mixed lineage kinase domain-like (MLKL).
K, Moriwaki, F K-M, Chan
openaire   +2 more sources

Dynamic Regulation of Collagens, Proteases, Their Inhibitors, and Cell Death in Experimental Asthma in Mice

Allergy, Volume 81, Issue 1, Page 170-184, January 2026.
This study investigates airway remodeling in acute and chronic experimental asthma models induced by house dust mite extract to elucidate inflammatory and structural changes. Two acute T2‐low models demonstrated pronounced airway inflammation characterized by goblet cell hyperplasia, collagen deposition, and significant upregulation of extracellular ...
Marlena Tynecka, Agnieszka Tarasik, Bartosz Hanczaruk, Adrian Janucik, Krystian Czolpinski, Alicja Walewska, Arkadiusz Zbikowski, Anna Zeller, Agnieszka Kulczynska‐Przybik, Magdalena Niemira, Joanna Reszec‐Gielazyn, Barbara Mroczko, Adam Kretowski, Cezmi A. Akdis, Milena Sokolowska, Marcin Moniuszko, Cagatay Karaaslan, Andrzej Eljaszewicz   +17 more
wiley   +1 more source

NEMO regulates a cell death switch in TNF signaling by inhibiting recruitment of RIPK3 to the cell death-inducing complex II [PDF]

, 2016
Incontinentia Pigmenti (IP) is a rare X-linked disease characterized by early male lethality and multiple abnormalities in heterozygous females. IP is caused by NF-κB essential modulator (NEMO) mutations.
Draber, P, Esposito, E, Pescatore, A, Ursini, MV, Walczak, H   +4 more
core   +1 more source

Dysregulation of the endosomal sorting complex III is linked to neurodegeneration in progressive multiple sclerosis

Brain Pathology, Volume 36, Issue 1, January 2026.
This study shows that components of the ESCRT‐III membrane repair machinery, VPS4B and CHMP2A, are dysregulated in progressive MS and are associated with higher neurodegeneration and inflammation. This might lead to improper function of the complex to inhibit the final stages of necroptosis activation and thus impede neuronal cell death.
Carmen Picon, Robertas Aleksynas, Marcelina Wojewska, Francesco de Virgiliis, Doron Merkler, Richard Reynolds   +5 more
wiley   +1 more source