Results 121 to 130 of about 19,353 (245)

RIPK3 deficiency blocks R-2-hydroxyglutarate–induced necroptosis in IDH-mutated AML cells

Science Advances
Mutant isocitrate dehydrogenases (IDHs) produce R-2-hydroxyglutarate (R-2HG), which inhibits the growth of most acute myeloid leukemia (AML) cells.
Shuanghong Zhu, Yingwan Luo, Kongfei Li, C. Mei, Yuxia Wang, Lingxu Jiang, Wei Wang, Qi Zhang, Wenli Yang, W. Lang, Xinping Zhou, Lu Wang, Yanling Ren, Liya Ma, L. Ye, Xin Huang, Jianjun Chen, Jie Sun, Hongyan Tong   +18 more
semanticscholar   +1 more source

Bacillus cereus Induces Necroptosis in Microglia via the RIPK1/3‐MLKL Pathway

MicrobiologyOpen, Volume 15, Issue 2, April 2026.
Bacillus cereus induces necroptosis in murine/human microglia via the RIPK1/3‐MLKL pathway, triggering inflammatory cytokine release—uncovering a new pathogenic mechanism for its severe ocular infection. ABSTRACT Bacillus cereus endophthalmitis is a rapidly progressing intraocular infection that often results in poor visual outcomes due to extensive ...
Jing Yang, Bianjin Sun, Huijing Xu, Yangyang Shen, Huili Ye, Qiheng Yuan, Siwen Chen, Meiqin Zheng   +7 more
wiley   +1 more source

RIPK3 mediates pathogenesis of experimental ventilator-induced lung injury [PDF]

JCI Insight, 2018
In patients requiring ventilator support, mechanical ventilation (MV) may induce acute lung injury (ventilator-induced lung injury [VILI]). VILI is associated with substantial morbidity and mortality in mechanically ventilated patients with and without acute respiratory distress syndrome. At the cellular level, VILI induces necrotic cell death. However,
Ilias I. Siempos, Kevin C. Ma, Mitsuru Imamura, Rebecca M. Baron, Laura E. Fredenburgh, Jin-Won Huh, Jong-Seok Moon, Eli J. Finkelsztein, Daniel S. Jones, Michael Torres Lizardi, Edward J. Schenck, Stefan W. Ryter, Kiichi Nakahira, Augustine M.K. Choi   +13 more
openaire   +2 more sources

Necrostatin-1 Analogues: Critical Issues on the Specificity, Activity and In Vivo Use in Experimental Disease Models [PDF]

, 2012
Necrostatin-1 (Nec-1) is widely used in disease models to examine the contribution of receptor-interacting protein kinase (RIPK) 1 in cell death and inflammation.
Callewaert, N, Cauwels, A, Declercq, W, Degterev, A, DuHadaway, J B, Duprez, L, Goossens, V, Grootjans, S, Libert, C, Nerinckx, W, Prendergast, G C, Roelandt, R, Takahashi, N, Van Hauwermeiren, F, Vandenabeele, P, Yuan, Junying   +15 more
core   +2 more sources

Expression of HIF1α in intestinal epithelium restricts arthritis inflammation by inhibiting RIPK3-induced cell death machinery

Annals of the Rheumatic Diseases
Objectives To investigate the mechanism by which intestinal epithelial cell (IEC) death induces arthritis. Methods IEC death was assessed by staining for necroptosis and apoptosis markers and fluorescence in situ hybridisation at different time points ...
P. Lyu, Jinming Wen, Wenshuo Zhang, Ning Liu, I. Stolzer, Andreas Gießl, Yewei Jia, D. Mauro, Fulin Zhang, F. Ciccia, D. Soulat, Claudia Günther, G. Schett, A. Bozec   +13 more
semanticscholar   +1 more source

Liquid–Liquid Phase Separation in Viral Infection and Immunology

MedComm, Volume 7, Issue 4, April 2026.
LLPS organizes viral replication and antiviral immunity. Viruses hijack LLPS to form replication factories and evade immune sensors, while hosts assemble LLPS‐driven signaling hubs (e.g., MAVS, RIG‐I, and SGs) to amplify interferon responses. Targeting these condensate interfaces offers novel therapeutic strategies against infectious diseases ...
Jiuzhi Xu, Lan Bai, Bin Wang, Hai Song, Long Zhang, Fangfang Zhou   +5 more
wiley   +1 more source

Necroptosis induced by RIPK3 requires MLKL but not Drp1 [PDF]

Cell Death & Disease, 2014
Necroptosis is a mechanism by which cells can kill themselves that does not require caspase activity or the presence of the pro-apoptotic Bcl-2 family members Bax or Bak. It has been reported that RIPK3 (receptor interacting protein kinase 3) activates MLKL (mixed lineage kinase domain-like) to cause cell death that requires dynamin-related protein 1 ...
Moujalled, DM, Cook, WD, Murphy, JM, Vaux, DL   +3 more
openaire   +3 more sources

Reformulating Pro-Oxidant Microglia in Neurodegeneration [PDF]

, 2019
In neurodegenerative diseases, microglia-mediated neuroinflammation and oxidative stress are central events. Recent genome-wide transcriptomic analyses of microglial cells under different disease conditions have uncovered a new subpopulation named ...
Alonso Bellido, Isabel María, Burguillos García, Miguel Ángel, Cruz Hernández, Luis, Espinosa Oliva, Ana María, García Domínguez, Irene, García Revilla, Juan, Herrera Carmona, Antonio José, Martínez de Pablos, Rocío, Roca Ceballos, María Angustias, Rodríguez Gómez, José Antonio, Ruiz Laza, Rocío, Santiago Pavón, Martiniano, Sarmiento Soto, Manuel, Venero Recio, José Luis   +13 more
core   +2 more sources

RIPK3 cleavage is dispensable for necroptosis inhibition but restricts NLRP3 inflammasome activation

Cell Death and Differentiation
Caspase-8 activity is required to inhibit necroptosis during embryogenesis in mice. In vitro studies have suggested that caspase-8 directly cleaves RIPK1, CYLD and the key necroptotic effector kinase RIPK3 to repress necroptosis.
H. Tran, Tobias Kratina, Auriane Coutansais, Dominika Michalek, Benjamin M. Hogan, Kate E. Lawlor, J. Vince, J. Silke, N. Lalaoui   +8 more
semanticscholar   +1 more source

Cerebral Infarction: Epidemiology, Classification, Mechanisms, Diagnosis, and Management

MedComm, Volume 7, Issue 4, April 2026.
Within minutes after ischemia onset, deprivation of oxygen and glucose leads to rapid ATP depletion, resulting in failure of Na+/K+‐ATPase activity and membrane depolarization. This ionic imbalance promotes uncontrolled synaptic release of glutamate and excessive activation of postsynaptic NMDA and AMPA receptors.
Meibiao Zhang, Jianxun Hou, Jia Kuang, Lei Hao, Zhao Yang   +4 more
wiley   +1 more source