Results 181 to 190 of about 15,294 (209)
RIPK3 Restricts Viral Pathogenesis via Cell Death-Independent Neuroinflammation [PDF]
Cell, 2017 Receptor-interacting protein kinase-3 (RIPK3) is an activator of necroptotic cell death, but recent work has implicated additional roles for RIPK3 in inflammatory signaling independent of cell death.
Yueh-Ming Loo +2 more
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RIPK1 and RIPK3 in antibacterial defence
Biochemical Society Transactions, 2022Upon sensing pathogenic bacterial infection, host cells activate a multitude of inflammatory and immunogenic responses to promote bacterial clearance and restore tissue homeostasis. RIPK1 and RIPK3 are two key players in antimicrobial defence, by either driving inflammatory signalling or inducing programmed cell death activation, ranging from apoptosis,
Hui Wen Yeap, Kaiwen W. Chen
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RIPK3 Signaling and Its Role in the Pathogenesis of Cancers
Cellular and Molecular Life Sciences, 2021RIPK3 (receptor-interacting protein kinase 3) is a serine/threonine-protein kinase. As a key component of necrosomes, RIPK3 is an essential mediator of inflammatory factors (such as TNFα-tumor necrosis factor α) and infection-induced necroptosis, a programmed necrosis.
Mitchell F. Denning +2 more
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Biomedicine and Pharmacotherapy, 2023 Myocardial fibrosis (MF) remains a prominent challenge in heart disease. The role of receptor-interacting protein kinase 3 (RIPK3)-mediated necroptosis is evident in the pathogenesis of numerous heart diseases. Concurrently, the activation of Ca2+/calmodulin-dependent protein kinase (CaMKII) is pivotal in cardiovascular disease (CVD).
Xiaosong Gu, Jianan Qian
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The role of RIPK3 in liver mitochondria bioenergetics and function
European Journal of Clinical Investigation, 2021AbstractBackgroundReceptor‐interacting protein kinase 3 (RIPK3) is a key player of regulated necrosis or necroptosis, an inflammatory form of cell death possibly governing outcomes in chronic liver diseases, such as nonalcoholic fatty liver disease and nonalcoholic steatohepatitis.MethodsThis narrative review is based on literature search using PubMed ...
Tawhidul Islam +2 more
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Mechanisms of RIPK3‐induced inflammation
Immunology & Cell Biology, 2017Receptor‐interacting protein kinase 3 (RIP3/RIPK3) is a multifunctional regulator of cell death and inflammation. It controls signalling downstream of the tumor necrosis factor (TNF) receptor family, DNA‐dependent activator of IFN‐regulatory factors (DAI) and toll‐like receptors (TLRs).
Inbar Shlomovitz +2 more
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Ring closure strategy leads to potent RIPK3 inhibitors
European Journal of Medicinal Chemistry, 2021Necroptosis is a form of regulated necrotic cell death that is independent of caspases. Receptor-interacting protein kinase 3 (RIPK3) has been identified as a key regulator for necroptosis, and has been proposed as a potential therapeutic target for the treatment of diseases associated with necroptosis. In this report, we describe the design, synthesis,
Shuwei, Wu +9 more
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The Inflammatory Signal Adaptor RIPK3: Functions Beyond Necroptosis [PDF]
International Review of Cell and Molecular Biology, 2017 Receptor interacting protein kinase 3 (RIPK3) is an essential serine/threonine kinase for necroptosis, a type of regulated necrosis. A variety of stimuli can cause RIPK3 activation through phosphorylation. Activated RIPK3 in turn phosphorylates and activates the downstream necroptosis executioner mixed lineage kinase domain-like (MLKL).
K, Moriwaki, F K-M, Chan
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SPOP-Mediated RIPK3 Destabilization Desensitizes LPS/sMAC/zVAD-Induced Necroptotic Cell Death [PDF]
Cellular and Molecular Life SciencesRIPK1/RIPK3-MLKL signaling molecules are fundamental in initiating necroptotic cell death, but their roles in the development of colon cancer are unclear.
Yong-Yeon Cho +2 more
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