Results 41 to 50 of about 19,353 (245)
Depletion of RIPK3 or MLKL blocks TNF-driven necroptosis and switches towards a delayed RIPK1 kinase-dependent apoptosis [PDF]
, 2014 In human cells, the RIPK1-RIPK3-MLKL-PGAM5-Drp1 axis drives tumor necrosis factor (TNF)-induced necroptosis through mitochondrial fission, but whether this pathway is conserved among mammals is not known. To answer this question, we analyzed the presence
Baekelandt, V +13 more
core +3 more sources
SARS-CoV-2 Z-RNA activates the ZBP1-RIPK3 pathway to promote virus-induced inflammatory responses
Cell Research, 2023 SARS-CoV-2 infection can trigger strong inflammatory responses and cause severe lung damage in COVID-19 patients with critical illness. However, the molecular mechanisms by which the infection induces excessive inflammatory responses are not fully ...
Shufen Li +11 more
semanticscholar +1 more source
RIPK3 Takes Another Deadly Turn [PDF]
Science, 2014 Blocking an enzyme involved in necroptosis may prove toxic by promoting another form of cell death. [Also see Report by Newton et al. ]
Jianke Zhang, Francis Ka-Ming Chan
openaire +1 more source
RIPK3 Promotes JEV Replication in Neurons via Downregulation of IFI44L
Frontiers in Microbiology, 2020 Japanese encephalitis virus (JEV), the leading cause of viral encephalitis in Asia, is neurovirulent and neuroinvasive. Neurons are the main target of JEV infection and propagation.
Peiyu Bian +13 more
doaj +1 more source
Viruses, 2022 Receptor interacting protein kinase 3 (RIPK3) is a vital serine/threonine kinase in regulating the programmed destruction of infected cells to defend against RNA viruses.
Guanming Tian +12 more
doaj +1 more source
Human RIPK3 C-lobe phosphorylation is essential for necroptotic signaling
Cell Death and Disease, 2022 Necroptosis is a caspase-independent, pro-inflammatory mode of programmed cell death which relies on the activation of the terminal effector, MLKL, by the upstream protein kinase RIPK3.
Yanxiang Meng +7 more
doaj +1 more source
Kinase domain dimerization drives RIPK3-dependent necroptosis [PDF]
Science Signaling, 2018 Necroptotic cell death is promoted by the dimerization-dependent activation of the kinase RIPK3.
Saravanan Raju +8 more
openaire +2 more sources
RIPK3 Contributes to Lyso-Gb3-Induced Podocyte Death [PDF]
Cells, 2021 Fabry disease is a lysosomal storage disease with an X-linked heritage caused by absent or decreased activity of lysosomal enzymes named alpha-galactosidase A (α-gal A). Among the various manifestations of Fabry disease, Fabry nephropathy significantly affects patients’ morbidity and mortality.
So-Young Kim +10 more
openaire +3 more sources
Cytoplasmic MYC is an anti-necroptotic protein
Molecular & Cellular Oncology, 2020 Cancer cells are often resistant to necroptosis as well as apotosis, but the underlying mechanisms are not fully understood. We recently revealed an important crosstalk between MYC, a potent oncogene, and receptor-interacting protein kinase 3 (RIPK3), a ...
Eun-Woo Lee +2 more
doaj +1 more source
Brainiac Caspases: Beyond the Wall of Apoptosis [PDF]
, 2019 For the last two decades, caspases, a family of cysteine-aspartic proteases, have evolved from being considered solely as regulators of apoptosis or inflammation to having a wider range of functions.
Alonso Bellido, Isabel María +3 more
core +1 more source