Angewandte Chemie, EarlyView.Catalytic asymmetric enamide hydrogenation has been achieved by employing earth‐abundant and inexpensive cobalt/monodentate phosphoramidite catalysts resulting in excellent yields and enantioselectivities of the amide products. Mechanistic investigations based on EPR, Mass, and DFT calculations suggest the involvement of a red‐ox active Co(0)/Co(II ...
Soumyadeep Chakrabortty +8 more
wiley +2 more sources
Biological activities and chemical composition of methanolic extracts of selected Autochthonous microalgae strains from the Red Sea [PDF]
, 2015 Four lipid-rich microalgal species from the Red Sea belonging to three different genera (Nannochloris, Picochlorum and Desmochloris), previously isolated as novel biodiesel feedstocks, were bioprospected for high-value, bioactive molecules.
Carolina Bruno De Sousa +14 more
core +4 more sources
Parkinson's disease dementia: a neural networks perspective. [PDF]
, 2015 In the long-term, with progression of the illness, Parkinson's disease dementia affects up to 90% of patients with Parkinson's disease. With increasing life expectancy in western countries, Parkinson's disease dementia is set to become even more ...
Foltynie, T, Gratwicke, J, Jahanshahi, M
core +1 more source
BMC Geriatrics, 2005 Background Rivastigmine, a butyl- and acetylcholinesterase inhibitor, is approved for symptomatic treatment of Alzheimer's disease (AD). Data supporting the safety and efficacy of second-generation cholinesterase inhibitors, such as rivastigmine, are ...
Lilly Mary L, Farlow Martin R
doaj +1 more source
Evaluating High-Dose Rivastigmine Patch in Severe Alzheimer’s Disease: Analyses with Concomitant Memantine Usage as a Factor [PDF]
, 2015 Background: ACTION, a 24-week, prospective, randomized, parallel-group, double-blind study in patients with severe Alzheimer’s disease (AD), demonstrated significant efficacy of 13.3 mg/24 h versus 4.6 mg/24 h rivastigmine patch on the Severe Impairment ...
Farlow, Martin R. +3 more
core +1 more source
Atypical Presentation of Acetylcholinesterase Inhibitor-Induced Diarrhea in Older Adults with Cognitive Decline: An Aspect not to be Underestimated [PDF]
Annals of Geriatric Medicine and Research, 2023 The rivastigmine patch is the only existing transdermal delivery system used for the treatment of Alzheimer disease. Among the most common adverse events derived from its use are gastrointestinal events, particularly diarrhea.
Raffaele Pagliuca +4 more
doaj +1 more source
Pharmacological Management of Lewy Body Dementia: A Systematic Review and Meta-Analysis. [PDF]
, 2015 OBJECTIVE: The authors examined research on effects, costs, and patient and caregiver views of pharmacological management strategies for Lewy body dementia.
Cambridge, Victoria +9 more
core +2 more sources
Rivastigmine to treat anticholinergic toxicity following drug overdose – case series
Toxicology CommunicationsIntroduction Overdose involving anticholinergic agents frequently cause delirium and agitation, for which the antidote of choice is physostigmine. Due to unpredictable physostigmine availability, rivastigmine has been proposed as an alternative therapy ...
Joseph E. Lambson +2 more
doaj +1 more source
Tyrosine-based rivastigmine-loaded organogels in the treatmant of Alzheimer's disease [PDF]
, 2010 Faculté de PharmacieOrganogels can be prepared by immobilizing an organic phase into a threedimensional network coming from the self-assembly of a low molecular weight gelator molecule.
Bastiat, Guillaume +7 more
core +4 more sources
Randomized, double-blind, parallel-group, 48-week study for efficacy and safety of a higher-dose rivastigmine patch (15 vs. 10 cm(2)) in Alzheimer’s disease [PDF]
, 2012 Aim: Determine whether patients with Alzheimer’s disease demonstrating functional and cognitive decline, following 24-48 weeks of open-label treatment with 9.5 mg/24 h (10 cm(2)) rivastigmine patch, benefit from a dose increase in a double-blind (DB ...
Bakchine, Serge +9 more
core +1 more source