Results 21 to 30 of about 9,997 (164)

Antimuscarinic delirium in a pediatric patient reversed with transdermal rivastigmine: A case report

JEM Reports
Background: Antidotal treatment of antimuscarinic delirium (AMD) standardly involves parenteral administration of physostigmine. However, due to cessation of physostigmine production, administration of oral or transdermal rivastigmine may serve as a ...
Natalie E. Ebeling-Koning, Natalie A. Burkert, Laura Koons, John D. Lindmark, Anthony F. Pizon, Kenneth D. Katz   +5 more
doaj   +1 more source

Design Considerations for Polymer–Deep Eutectic Solvent Hybrid Systems for Transdermal Drug Delivery

Journal of Applied Polymer Science, EarlyView.
Deep eutectic solvents (DESs) act as tunable, green excipients that modulate polymer structure–property relationships to enhance drug solubility, skin permeation, stability, and controlled release. Through hydrogen‐bond interactions, DES–polymer hybrid systems enable improved transdermal performance, offering a rational, design‐driven platform for ...
Madhavi Kailas Kapale, Madhur Kulkarni, Pranav J. Shah, Furqan A. Maulvi   +3 more
wiley   +1 more source

Connecting the dots: A narrative review of the relationship between heart failure and cognitive impairment

ESC Heart Failure, Volume 12, Issue 2, Page 1119-1131, April 2025.
Abstract Large clinical data underscore that heart failure is independently associated to an increased risk of negative cognitive outcome and dementia. Emerging evidence suggests that cerebral hypoperfusion, stemming from reduced cardiac output and vascular pathology, may contribute to the largely overlapping vascular dementia and Alzheimer's disease ...
Mauro Massussi, Maria Giulia Bellicini, Marianna Adamo, Andrea Pilotto, Marco Metra, Alessandro Padovani, Riccardo Proietti   +6 more
wiley   +1 more source

Serum Concentrations of Cholinesterase Inhibitors in Patients With Alzheimer’s Dementia Are Frequently Below the Recommended Levels

Frontiers in Pharmacology, 2020
BackgroundAcetylcholinesterase inhibitors (AChE-I) are recommended for the treatment of cognitive symptoms but also of behavioral and psychological symptoms in dementia.
Marion Ortner, Marion Stange, Heike Schneider, Charlotte Schroeder, Katharina Buerger, Katharina Buerger, Claudia Müller, Bianca Dorn, Oliver Goldhardt, Janine Diehl-Schmid, Hans Förstl, Werner Steimer, Timo Grimmer   +12 more
doaj   +1 more source

Rivastigmine for ECT-induced cognitive adverse effects in late life depression (RECALL study): A multicenter, randomized, double blind, placebo-controlled, cross-over trial in patients with depression aged 55 years or older: Rationale, objectives and methods

Frontiers in Psychiatry, 2022
BackgroundCognitive side-effects are an important reason for the limited use of electroconvulsive therapy (ECT). Cognitive side-effects are heterogeneous and occur frequently in older persons.
Marieke J. Henstra, Marieke J. Henstra, Marieke J. Henstra, Thomas C. Feenstra, Thomas C. Feenstra, Rob M. Kok, Harm-Pieter Spaans, Eric van Exel, Eric van Exel, Eric van Exel, Eric van Exel, Annemiek Dols, Annemiek Dols, Annemiek Dols, Annemiek Dols, Annemiek Dols, Mardien Oudega, Mardien Oudega, Mardien Oudega, Mardien Oudega, Anton C. M. Vergouwen, Adriano van der Loo, Pierre M. Bet, Stephan A. Loer, Merijn Eikelenboom, Merijn Eikelenboom, Pascal Sienaert, Simon Lambrichts, Filip Bouckaert, Judith E. Bosmans, Judith E. Bosmans, Nathalie van der Velde, Nathalie van der Velde, Aartjan T. F. Beekman, Aartjan T. F. Beekman, Aartjan T. F. Beekman, Max L. Stek, Didi Rhebergen, Didi Rhebergen, Didi Rhebergen   +39 more
doaj   +1 more source

Antiseizure potency and neurotoxicity of the enantiomers of fenfluramine and norfenfluramine in rats and correlations with their concentrations in plasma and brain

Epilepsia, EarlyView.
Abstract Objective Based on the evidence that fenfluramine‐induced anorexia, weight loss, and cardiovascular toxicity are primarily mediated by the d‐enantiomers of fenfluramine and its metabolite norfenfluramine, we investigated pharmacokinetic/pharmacodynamic correlations for the active enantiomers of fenfluramine and norfenfluramine in the rat ...
Yara Sheeni, Dinorah Barasch, Tawfeeq Shekh‐Ahmad, Emilio Perucca, Meir Bialer   +4 more
wiley   +1 more source

Ambient technology in epilepsy clinical practice

Epilepsia Open, EarlyView.
Abstract The utilization of large language model‐based artificial intelligence (AI) in the field of neurology has gained attention as a viable tool to enhance and assist providers with processes ranging from scheduling patients to providing preliminary interpretations of testing results, pending orders, and documenting encounters. Epileptologists could
Haania Kakwan, Justin F. Rousseau, Lidia M. Moura, Irfan S. Sheikh   +3 more
wiley   +1 more source

Vocal Fold Atrophy in Patients With Alzheimer's Disease and Related Dementias

The Laryngoscope, EarlyView.
This is the first study to quantify vocal fold atrophy in patients with Alzheimer's disease and related dementias (AD/ADRD) using endoscopic imaging. Compared with age‐matched controls, AD/ADRD patients showed significantly greater vocal fold bowing and reduced mucosal wave amplitude, while normalized glottal gap area did not differ.
Byron Kim, Carson Miller, Shruti Dhingra, Mahdi Al‐Ghezi, Emily Wilson, Neel K. Bhatt   +5 more
wiley   +1 more source

Rivastigmine Improves Appetite by Increasing the Plasma Acyl/Des-Acyl Ghrelin Ratio and Cortisol in Alzheimer Disease

Dementia and Geriatric Cognitive Disorders Extra, 2018
Background: Weight loss accelerates cognitive decline and increases mortality in patients with dementia. While acetylcholinesterase (AChE) inhibitors are known to cause appetite loss, we sometimes encounter patients in whom switching from donepezil (AChE
Yoshiko Furiya, Takami Tomiyama, Tesseki Izumi, Naoki Ohba, Satoshi Ueno   +4 more
doaj   +1 more source

Improvement in delirium and visuospatial function after rivastigmine in antimuscarinic toxicity: a case report

Toxicology Communications, 2023
Treatment of antimuscarinic toxicity has become more difficult in the United States due to an ongoing national shortage of physostigmine. Rivastigmine has emerged as an alternative, off-label therapy due to its similar mechanism of action as a reversible,
Matthew S. Correia, Robert G. Hendrickson   +1 more
doaj   +1 more source