Approximations and their consequences for dynamic modelling of signal transduction pathways [PDF]
, 2007 Signal transduction is the process by which the cell converts one kind of signal or stimulus into another. This involves a sequence of biochemical reactions, carried out by proteins.
Asthagiri +49 more
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Transcriptional Regulation of RKIP Expression by Androgen in Prostate Cells [PDF]
Cellular Physiology and Biochemistry, 2012 Raf kinase inhibitory protein (RKIP) is a scaffolding molecule in the PEBP family that sequesters certain signaling molecules away from their pathways, thereby abrogating intracellular growth signals. RKIP has been assigned multiple functions and is associated with an increasing number of diseases through its involvement with signal transduction ...
Honglai, Zhang +5 more
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Neoplasia: An International Journal for Oncology Research, 2013 p53, a strong tumor suppressor protein, is known to be involved in cellular senescence, particularly premature cellular senescence. Oncogenic stresses, such as Ras activation, can initiate p53-mediated senescence, whereas activation of the Ras-mitogen ...
Su-Jin Lee +3 more
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G protein-coupled receptor kinase 2 (GRK2) as a potential therapeutic target in cardiovascular and metabolic diseases [PDF]
, 2019 G protein-coupled receptor kinase 2 (GRK2) is a central signaling node involved in the modulation of many G protein-coupled receptors (GPCRs) and also displaying regulatory functions in other cell signaling routes.
Arcones, Alba C. +5 more
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Indirect treatment comparison of dabrafenib plus trametinib versus vemurafenib plus cobimetinib in previously untreated metastatic melanoma patients. [PDF]
, 2017 BackgroundMetastatic melanoma is an aggressive form of skin cancer with a high mortality rate and the fastest growing global incidence rate of all malignancies.
Ahuja, Amit +4 more
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The Expression and Significance of RKIP in Lung Squamous Cell Carcinoma Tissues
Chinese Journal of Lung Cancer, 2011 Background and objective Raf kinase inhibitory protein (RKIP) belongs to the phosphatidylethanolamine binding protein (PEBP) family. RKIP is an endogenous inhibitor of the Raf-1-MEK1/2-ERK1/2 signaling pathway, NFkappaB signaling pathway and G protein ...
Haiyuan XU +6 more
doaj
BioNessie - a grid enabled biochemical networks simulation environment [PDF]
, 2008 The simulation of biochemical networks provides insight and understanding about the underlying biochemical processes and pathways used by cells and organisms.
Ajayi, O. +5 more
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RKIP-Mediated Chemo-Immunosensitization of Resistant Cancer Cells via Disruption of the NF-κB/Snail/YY1/RKIP Resistance-Driver Loop [PDF]
Critical Reviews in Oncogenesis, 2014 Cancer remains one of the most dreadful diseases. Whereas most treatment regimens for various cancers have resulted in improved clinical responses and sometimes cures, unfortunately, subsets of cancer patients are either pretreatment resistant or develop resistance following therapy.
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Molecular Oncology, Volume 19, Issue S1, Page 1-940, June 2025.Abstracts submitted to the ‘EACR 2025 Congress: Innovative Cancer Science’, from 16–19 June 2025 and accepted by the Congress Organising Committee are published in this Supplement of Molecular Oncology, an affiliated journal of the European Association for Cancer Research (EACR).
wiley +1 more source
Overexpression of RKIP and its cross-talk with several regulatory gene products in multiple myeloma
Journal of Experimental & Clinical Cancer Research, 2017 Multiple myeloma (MM) is a clonal plasma-cell neoplastic disorder arising from an indolent premalignant disease known as monoclonal gammopathy of undetermined significance (MGUS).
Anna Shvartsur +3 more
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