Results 111 to 120 of about 1,582 (158)

Mechanism-guided radiosensitization strategies for nasopharyngeal carcinoma: Current evidence and translational perspectives (Review). [PDF]

Oncol Lett
Deng W, Li Z, Zhu Z.
europepmc   +1 more source

Decoding the Snail transcriptional network: its role in cancer progression and therapy. [PDF]

Biol Direct
Parfenyev SE, Nazarov AN, Daks AA, Fedorova OA, Barlev NA, Shuvalov OY.   +5 more
europepmc   +1 more source

Pharmacological advances of honokiol: Mechanisms, targets and therapeutic potential (Review). [PDF]

Biomed Rep
Jiang W.
europepmc   +1 more source

The Role of RKIP in the Regulation of EMT in the Tumor Microenvironment

Cancers, 2022
The Raf Kinase Inhibitor Protein (RKIP) is a unique gene product that directly inhibits the Raf/Mek/Erk and NF-kB pathways in cancer cells and resulting in the inhibition of cell proliferation, viability, EMT, and metastasis. Additionally, RKIP is involved in the regulation of cancer cell resistance to both chemotherapy and immunotherapy.
Benjamin Bonavida, Stavroula Baritaki, Apostolos Zaravinos   +2 more
exaly   +3 more sources

RKIP Structure Drives Its Function: A Three-State Model for Regulation of RKIP [PDF]

Critical Reviews in Oncogenesis, 2014
Raf kinase inhibitory protein (RKIP) is a highly conserved regulator of many signaling networks whose loss or inactivation can lead to a variety of disease states. The multifaceted roles played by RKIP are enabled by an allosteric structure that is controlled through phosphorylation of RKIP and dynamics in the RKIP pocket loop.
Marsha Rosner
exaly   +3 more sources

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Raf Kinase Inhibitor Protein (RKIP) in Cancer

Cancer and Metastasis Reviews, 2012
Raf kinase inhibitory protein (RKIP) was initially identified as phosphatidylethanolamine binding protein in bovine brain. It was later identified as a protein that inhibits Raf kinase activation of MEK. Further exploration has revealed that RKIP modulates several other signaling pathways including NF-κB and G-protein signaling.
Kam C Yeung, Evan T Keller, June Escara-Wilke   +2 more
exaly   +3 more sources

Raf Kinase Inhibitor Protein (RKIP) and Phospho-RKIP Expression in Melanomas

Acta Histochemica, 2013
Melanoma, a cancer notorious for its high potential to metastasize, arises from melanocytes, cells dedicated to melanin production and located in the basal layer of the epidermis. Raf-1 kinase inhibitor protein (RKIP) is an inhibitory molecule that down-regulates the effects of the Ras/Raf/MEK/ERK signaling pathway. The aim of this study was to examine
Carla Loreto, Grazia Malaponte, Venera Cardile   +2 more
exaly   +4 more sources

Genetic and Epigenetic Control of RKIP Transcription

Critical Reviews in Oncogenesis, 2014
Raf kinase inhibitory protein (RKIP) is known to modulate key signaling cascades and regulate normal physiological processes such as cellular proliferation, differentiation, and apoptosis. The expression of RKIP is found to be downregulated in several cancer metastases and the repressed RKIP expression can be reactivated on treatment with ...
Fahd Al-mulla, Milad S Bitar, Ila Datar
exaly   +3 more sources