Results 121 to 130 of about 1,582 (158)

RKIP and cytotrophoblast motility

Journal of Cellular Physiology, 2012
Motility PASQUAPINA CIARMELA,* DANIELA MARZIONI, MD. SORIFUL ISLAM, PETER CLARKE GRAY, LUIGI TERRACCIANO, TERESA LORENZI, TULLIA TODROS, FELICE PETRAGLIA, AND MARIO CASTELLUCCI Faculty of Medicine, Department of Experimental and Clinical Medicine, Polytechnic University of Marche, Ancona, Italy Clayton Foundation Laboratories for Peptide Biology, The ...
Ciarmela P, Marzioni D, Islam MS, Gray PC, Terracciano L, Lorenzi T, TODROS, Tullia, Petraglia F, Castellucci M.   +8 more
openaire   +3 more sources

RKIP: A Governor of Intracellular Signaling

Critical Reviews in Oncogenesis, 2014
The Raf kinase inhibitor protein (RKIP) increasingly evolves as an important regulator of intracellular signaling networks and thus participates in diverse physiological functions ranging from growth and differentiation processes to muscle contraction.
Kristina, Lorenz, Evelyn, Schmid, Katharina, Deiss   +2 more
openaire   +2 more sources

Killing two birds with one RKIP

Trends in Endocrinology and Metabolism, 2004
Analysis of metastatic prostate cancers has identified the Raf kinase inhibitory protein (RKIP) as a suppressor of metastases. Previous studies demonstrated that RKIP binds to Raf-1 and prevents the activation of the extracellular regulated kinase (ERK) cascade. New work shows that phosphorylation of RKIP by protein kinase C disassociates RKIP from Raf-
Reema, Goel, Joseph J, Baldassare
openaire   +2 more sources

Loss of RKIP Expression Is Associated With Poor Survival in GISTs

Virchows Archiv Fur Pathologische Anatomie Und Physiologie Und Fur Klinische Medizin, 2009
Gastrointestinal stromal tumours (GISTs) are rare mesenchymal tumours of the digestive tract and are commonly driven by oncogenic mutations in KIT and PDGFRA genes. Tumour size, location, mitotic index and KIT/PDGFRA mutations are the most important prognostic parameters in GISTs.
Olga Martinho, Rui Manuel Reis
exaly   +4 more sources

Unique Pattern of Raf-1 Kinase Inhibitory Protein (RKIP) Expression in Multiple Myeloma (MM): RKIP Overexpression and RKIP Phosphorylation Is Common in MM Tumor Cells

Blood, 2008
Abstract Objective and Rationale Raf-1 kinase inhibitor protein (RKIP) is a modulator of cell signaling and survival that functions as an endogenous inhibitor of multiple kinases, including kinases involved in the Raf-1/MEK/ERK and NF-kB pathways.
Benjamin Bonavida, James R. Berenson, Haiming Chen, Manuel L Penichet, Kam Yeung, Clara Rivera-Pazos, Ma de Lourdes Cabera-Muñoz, Sara Huerta-Yepez, Stavroula Baritaki   +8 more
openaire   +1 more source

Resveratrol binds and activates RKIP protein in colorectal cancer

Amino Acids, 2020
Raf-1 kinase inhibitory protein (RKIP) acts as a tumor cell metastasis suppressor and prognostic indicator for survival in various cancers. Its use is predicted to improve therapy for various malignancies, including colorectal cancer (CRC). RKIP, frequently denoted as phosphatidylethanolamine-binding protein 1, is expressed in all normal mammalian ...
Begum Dariya, Santosh Kumar Behera, Gowru Srivani, Sheik Aliya, Afroz Alam, Ganji Purnachandra Nagaraju   +5 more
openaire   +2 more sources

Unique Pattern of Raf-1 Kinase Inhibitory Protein (RKIP) Expression in Multiple Myeloma (MM) Compared to Other Tumor Types: Overexpression of RKIP and a Phosphorylated RKIP Is Common in MM Tumor Cells.

Blood, 2007
Abstract Objective and Rationale Raf-1 kinase inhibitory protein (RKIP) is a modulator of cell signaling and survival that functions as an endogenous inhibitor of multiple kinases, including kinases involved in the Raf/MEK/ERK and NF-κB pathways.
Stavroula Baritaki, Sara Huerta-Yepez, Kam Yeung, Manuel Penichet, Haiming Chen, Dror Shalitin, James Berenson, Benjamin Bonavida   +7 more
openaire   +1 more source

Role of RKIP in the tumor response to photooxidative damage

2020
The Raf-kinase inhibitor protein (RKIP) plays a role in the regulation of different processes, through its interaction with several signaling pathways. These pathways include the mitogen activated protein kinase (MAPK), nuclear factor kappa-light chain enhancer of activated B cells (NF-κB), G protein-coupled receptors (GPCR) and glycogen synthase ...
Rapozzi V., Xodo L. E.
openaire   +1 more source

Possible role of RKIP in cytotrophoblast migration: immunohistochemical and in vitro studies

Journal of Cellular Physiology, 2012
AbstractRaf kinase inhibitor protein (RKIP) regulates growth and differentiation signaling of mitogen‐activated protein kinases (MAPK), GRK2 and NF‐kappaB pathways each of which regulates cytotrophoblast differentiation and normal placental development.
Ciarmela P, Marzioni D, Islam MS, Gray PC, Terracciano L, Lorenzi T, TODROS, Tullia, Petraglia F, Castellucci M.   +8 more
openaire   +4 more sources

Mathematical Modeling of the Influence of RKIP on the ERK Signaling Pathway

2003
This paper investigates the influence of the Raf Kinase Inhibitor Protein (RKIP) on the Extracellular signal Regulated Kinase (ERK) signaling pathway through mathematical modeling and simulation. Using nonlinear ordinary differential equations to represent biochemical reactions in the pathway, we suggest a technique for parameter estimation, utilizing ...
Kwang-Hyun Cho, Sung-Young Shin, Hyun Woo Kim, Olaf Wolkenhauer, Brian McFerran, Walter Kolch   +5 more
openaire   +2 more sources