Results 81 to 90 of about 3,611 (194)

Evolutionary origin and functional investigation of the widely conserved plant PEBP gene STEPMOTHER OF FT AND TFL1 (SMFT)

The Plant Journal, Volume 120, Issue 4, Page 1410-1420, November 2024.
SUMMARY Genes of the family PHOSPHATIDYLETHANOLAMINE‐BINDING PROTEINS (PEBP) have been intensely studied in plants for their role in cell (re)programming and meristem differentiation. Recently, sporadic reports of the presence of a new type of PEBP in plants became available, highly similar to the YY‐PEBPs of prokaryotes.
Francesca Bellinazzo, Judit Nadal Bigas, Rensco A. H. Hogers, Jan Kodde, Froukje van der Wal, Pinelopi Kokkinopoulou, Kilian T. M. Duijts, Gerco C. Angenent, Aalt D. J. van Dijk, Robin van Velzen, Richard G. H. Immink   +10 more
wiley   +1 more source

Implication of RAF and RKIP Genes in Urinary Bladder Cancer

Pathology & Oncology Research, 2010
RKIP has been shown to regulate the RAS-RAF-MEK-ERK kinase cascade acting as modulator of apoptosis and metastasis in prostate cancer. Our goal was to examine the expression of the RAF (A-RAF, B-RAF and RAF-1) and RKIP genes in urinary bladder cancer.
Zaravinos, A., Chatziioannou, M., Lambrou, G.I., Boulalas, I., Delakas, D., Spandidos, D.A.   +5 more
openaire   +3 more sources

NeiyiKangfu tablets control the progression of endometriosis through inhibiting RAF/MEK/ERK signal pathway by targeting RKIP

Gynecological Endocrinology, 2022
Background NeiyiKangfu tablets (NYKF) are widely used clinically for the treatment of endometriosis (EMS), whose mechanism of action has been extensively studied.
Yi Wen, Lingxiu Fan, Lili Pang, Tingting Zhao, Ruonan Li, Ying Zhang, Liye Zhang, Wei Yang   +7 more
doaj   +1 more source

Merkel Cell Polyomavirus—Pathophysiology and Treatment in the Era of Gene‐Targeted Therapies

Reviews in Medical Virology, Volume 34, Issue 5, September 2024.
ABSTRACT Merkel cell polyomavirus (MCPyV) is a significant contributor to the development of Merkel cell carcinoma (MCC), an aggressive skin cancer with high recurrence and a low survival rate. In fact, it is the deadliest skin cancer. The precise routes of transmission for MCPyV‐positive MCC remain unclear, but several factors may trigger its ...
Trairong Chokwassanasakulkit, Nigel A. J. McMillan   +1 more
wiley   +1 more source

RKIP inhibits the malignant phenotypes of gastric cancer cells

Neoplasma, 2012
Raf kinase inhibitor protein (RKIP) is first identified as an interacting partner of Raf-1. RKIP expression is low or absent in several established cell lines derived from metastatic breast cancer, prostate cancer and melanoma cells. However, the functional role of RKIP in gastric cancer remains unclear.
X M, Zhang, H, Gu, L, Yan, G Y, Zhang
openaire   +3 more sources

RKIP as an Inflammatory and Immune System Modulator: Implications in Cancer

Biomolecules, 2019
Raf kinase inhibitor protein (RKIP), an important modulator of intracellular signalling pathways, is commonly downregulated in multiple cancers. This reduction, or loss of expression, is correlated not only with the presence of metastasis, contributing ...
Maria Gabriela-Freitas, Joana Pinheiro, Ana Raquel-Cunha, Diana Cardoso-Carneiro, Olga Martinho   +4 more
doaj   +1 more source

Directivity patterns of laser-generated sound in solids: Effects of optical and thermal parameters [PDF]

, 2014
In the present paper, directivity patterns of laser-generated sound in solids are investigated theoretically. Two main approaches to the calculation of directivity patterns of laser-generated sound are discussed for the most important case of thermo ...
Krylov, Victor V.
core   +2 more sources

Immune‐mediated disruption of the blood–brain barrier after intracerebral hemorrhage: Insights and potential therapeutic targets

CNS Neuroscience &Therapeutics, Volume 30, Issue 7, July 2024.
Blood–brain barrier disruption and immune system infiltration after intracerebral hemorrhage. Abstract Aims Intracerebral hemorrhage (ICH) is a condition that arises due to the rupture of cerebral blood vessels, leading to the flow of blood into the brain tissue.
Peijun Jia, Qinfeng Peng, Xiaochong Fan, Yumeng Zhang, Hanxiao Xu, Jiaxin Li, Houn Sonita, Simon Liu, Anh Le, Qiongqiong Hu, Ting Zhao, Shijie Zhang, Junmin Wang, Marietta Zille, Chao Jiang, Xuemei Chen, Jian Wang   +16 more
wiley   +1 more source

Cyclin‐dependent kinase 5 (CDK5) inhibitors in Parkinson disease

Journal of Cellular and Molecular Medicine, Volume 28, Issue 11, June 2024.
Abstract Cyclin‐dependent kinase 5 (Cdk5) is a protein expressed in postmitotic neurons in the central nervous system (CNS). Cdk5 is activated by p35 and p39 which are neuron regulatory subunits. Cdk5/p35 complex is activated by calpain protease to form Cdk5/p35 which has a neuroprotective effect by regulating the synaptic plasticity and memory ...
Mohammed Alrouji, Haydar M. Al‐kuraishy, Ali I. Al‐Gareeb, Mohammed S. Alshammari, Athanasios Alexiou, Marios Papadakis, Mostafa M. Bahaa, Gaber El‐Saber Batiha   +7 more
wiley   +1 more source

E-cadherin expression is associated with somatostatin analogue response in acromegaly [PDF]

, 2018
Acromegaly is a rare disease resulting from hypersecretion of growth hormone (GH) and insulin‐like growth factor 1 (IGF1) typically caused by pituitary adenomas, which is associated with increased mortality and morbidity. Somatostatin analogues (SSAs)
Cano, David A., Castaño, Justo P., Dios, Elena, Flores Martínez, Álvaro, Ibáñez Costa, Alejandro, Japón Rodríguez, Miguel Ángel, Luque, Raúl M., Madrazo Atutxa, Ainara, Soto Moreno, Alfonso Manuel, Venegas Moreno, Eva, Vázquez Borrego, Mari C.   +10 more
core   +1 more source