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Interaction and cross-talk between non-coding RNAs. [PDF]
, 2017 Non-coding RNA (ncRNA) has been shown to regulate diverse cellular processes and functions through controlling gene expression. Long non-coding RNAs (lncRNAs) act as a competing endogenous RNAs (ceRNAs) where microRNAs (miRNAs) and lncRNAs regulate each ...
Dahiya, Rajvir +3 more
core +2 more sources
Circular RNAs and Cardiovascular Regeneration [PDF]
Frontiers in Cardiovascular Medicine, 2021 circular RNAs (circRNAs) are a type of non-coding RNAs that are widely present in eukaryotic cells. They have the characteristics of stable structure, high abundance, and cell or tissue specific expression. circRNAs are single-stranded RNAs that are covalently back spliced to form closed circular loops.
Ling Tang +3 more
openaire +3 more sources
Biochimica et Biophysica Acta (BBA) - Gene Regulatory Mechanisms, 2020 Skeletal muscles have an immense ability to regenerate from the muscle stem cells called satellite cells. The process of skeletal muscle regeneration is called myogenesis, which starts with activation of quiescent satellite cells immediately after muscle injury followed by proliferation and fusion of myoblasts into myotubes.
Arundhati, Das +4 more
openaire +3 more sources
Circular RNA Regulation of Myogenesis
Cells, 2019 Circular RNA (circRNA) is a novel class of non-coding RNA generated by pre-mRNA back splicing, which is characterized by a closed-loop structure. Although circRNAs were firstly reported decades ago, their regulatory roles have not been discovered until ...
Pengpeng Zhang +10 more
doaj +1 more source
EXCLI Journal : Experimental and Clinical Sciences, 2023 Circular RNAs (CircRNAs) are a class of regulatory RNA transcripts, which are ubiquitously expressed in eukaryotes. CircRNA dysregulation has been shown to disrupt the interaction of the Wnt/β-catenin pathway, which regulates several biological processes involved in tumorigenesis, thereby contributing to the development and progression of cancer ...
Mina Alimohammadi +7 more
openaire +1 more source
Circular DNA tumor viruses make circular RNAs [PDF]
Proceedings of the National Academy of Sciences, 2018 Significance Circular RNAs (circRNAs) play critical physiologic functions, but it is not known whether human DNA viruses express circRNAs. We surveyed Epstein−Barr virus (EBV) and Kaposi’s sarcoma herpesvirus (KSHV) tumors and cell lines, and found specific circRNAs expressed from both viruses.
Tuna Toptan +8 more
openaire +2 more sources
Cost-Effective Transcriptome-Wide Profiling of Circular RNAs by the Improved-tdMDA-NGS Method
Frontiers in Molecular Biosciences, 2022 Covalently closed circular RNAs are neoteric to the eukaryotic family of long non-coding RNAs emerging as a result of 5′–3′ backsplicing from exonic, intronic, or intergenic regions spanning the parental gene.
Ashirbad Guria +5 more
doaj +1 more source
FUS affects circular RNA expression in murine embryonic stem cell-derived motor neurons [PDF]
, 2017 The RNA-binding protein FUS participates in several RNA biosynthetic processes and has been linked to the pathogenesis of amyotrophic lateral sclerosis (ALS) and frontotemporal dementia.
Bozzoni, Irene +14 more
core +1 more source
Cell Transplantation, 2019 Emerging evidence demonstrates that dysregulation of circular RNA is linked to tumorigenesis and aggressive progression. However, its role in oral squamous cell carcinoma remains largely uncharacterized.
Bing Xia +4 more
doaj +1 more source
ViFi: accurate detection of viral integration and mRNA fusion reveals indiscriminate and unregulated transcription in proximal genomic regions in cervical cancer. [PDF]
, 2018 The integration of viral sequences into the host genome is an important driver of tumorigenesis in many viral mediated cancers, notably cervical cancer and hepatocellular carcinoma.
Bafna, Vineet +4 more
core +1 more source