Results 121 to 130 of about 502,163 (208)

RNA recognition by double-stranded RNA binding domains: a matter of shape and sequence [PDF]

, 2018
The double-stranded RNA binding domain (dsRBD) is a small protein domain of 65-70 amino acids adopting an αβββα fold, whose central property is to bind to double-stranded RNA (dsRNA).
Allain, Frédéric, Barraud, Pierre, Masliah, Grégoire   +2 more
core  

Activation of PKR by a short-hairpin RNA

Scientific Reports
Recognition of viral infection often relies on the detection of double-stranded RNA (dsRNA), a process that is conserved in many different organisms. In mammals, proteins such as MDA5, RIG-I, OAS, and PKR detect viral dsRNA, but struggle to differentiate
Kyle A. Cottrell, Sua Ryu, Helen Donelick, Hung Mai, Addison A. Young, Jackson R. Pierce, Brenda L. Bass, Jason D. Weber   +7 more
doaj   +1 more source

An RNA condensate model for the origin of life [PDF]

arXiv
The RNA World hypothesis predicts that self-replicating RNAs evolved before DNA genomes and coded proteins. Despite widespread support for the RNA World, self-replicating RNAs have yet to be identified in a natural context, leaving a key 'missing link' for this explanation of the origin of life.
arxiv  

Effects of pH on Double Stranded RNA Stability in European Corn Borer Nucleases [PDF]

, 2019
RNA interference (RNAI) is an immune response that can be exploited to make greener pesticides. It works by inciting suppression of a specific target gene using fed or injected dsRNA.
Biondi, Marie, Cooper, Anastasia, Song, Huifang, Yu, Zhitao, Zhu, Kun Yan   +4 more
core  

Comprehensive benchmarking of large language models for RNA secondary structure prediction [PDF]

arXiv
Inspired by the success of large language models (LLM) for DNA and proteins, several LLM for RNA have been developed recently. RNA-LLM uses large datasets of RNA sequences to learn, in a self-supervised way, how to represent each RNA base with a semantically rich numerical vector.
arxiv  

Neuroprotective effects of minocycline on double-stranded RNA-induced neurotoxicity in cultured cortical neurons [PDF]

, 2012
1. Minocycline, memantine,and glycoconjugate were assessed for their ability to protect cultured primary cortical neurons against double-stranded RNA-induced neurotoxicity. 2.
Chang, RCC, Cheung, YT, Ho, YS, Lai, SW, So, KF, Yik, SY, Yu, MS   +6 more
core  

RiboFlow: Conditional De Novo RNA Sequence-Structure Co-Design via Synergistic Flow Matching [PDF]

arXiv
Ribonucleic acid (RNA) binds to molecules to achieve specific biological functions. While generative models are advancing biomolecule design, existing methods for designing RNA that target specific ligands face limitations in capturing RNA's conformational flexibility, ensuring structural validity, and overcoming data scarcity.
arxiv  

A Comparative Review of RNA Language Models [PDF]

arXiv
Given usefulness of protein language models (LMs) in structure and functional inference, RNA LMs have received increased attentions in the last few years. However, these RNA models are often not compared against the same standard. Here, we divided RNA LMs into three classes (pretrained on multiple RNA types (especially noncoding RNAs), specific-purpose
arxiv  

RNAi Double-Stranded RNA Directs the ATP-Dependent Cleavage of mRNA at 21 to 23 Nucleotide Intervals

Cell, 2000
P. Zamore, T. Tuschl, P. Sharp, D. Bartel   +3 more
semanticscholar   +1 more source

RiboDiffusion: Tertiary Structure-based RNA Inverse Folding with Generative Diffusion Models [PDF]

arXiv
RNA design shows growing applications in synthetic biology and therapeutics, driven by the crucial role of RNA in various biological processes. A fundamental challenge is to find functional RNA sequences that satisfy given structural constraints, known as the inverse folding problem.
arxiv