Results 61 to 70 of about 502,163 (208)

Virus Evolution: Fitting Lifestyles to a T [PDF]

, 2005
The structure of a double-stranded RNA virus outer shell has revealed unexpected similarities with virions of positive-strand RNA viruses. These similarities intersect with emerging parallels in RNA replication to create intriguing evolutionary ...
Ahlquist, Paul
core   +1 more source

Comparative Analysis of RNA Families Reveals Distinct Repertoires for Each Domain of Life [PDF]

PLoS Comput Biol. 2012 8(11):e1002752, 2012
The RNA world hypothesis, that RNA genomes and catalysts preceded DNA genomes and genetically-encoded protein catalysts, has been central to models for the early evolution of life on Earth. A key part of such models is continuity between the earliest stages in the evolution of life and the RNA repertoires of extant lineages.
arxiv   +1 more source

2006. aasta Nobeli auhind füsioloogias ja meditsiinis [PDF]

, 2006
2006. aasta Nobeli auhinna füsioloogia ja meditsiini alal pälvisid Andrew Z. Fire ja Craig C. Mellouurimuse eest teemal “RNA interferents – geenidevaigistamine kahe ahelalise RNA abil” (“RNAinterference – gene silencing by double-stranded RNA”).
Tamm, Riin
core   +2 more sources

Tomato chlorosis virus CPm protein is a pathogenicity determinant and suppresses host local RNA silencing induced by single-stranded RNA

Frontiers in Microbiology, 2023
IntroductionTomato chlorosis virus (ToCV) is a typical member of the genus Crinivirus, which severely threatens Solanaceae crops worldwide. The CPm protein encoded by ToCV has been reported to be associated with virus transmission by vectors and is ...
Xiao Yang, Xiangwen Luo, Xiangwen Luo, Yu Zhang, Zhanhong Zhang, Zhanhong Zhang, Xian OuYang, Xiaobin Shi, Xiaobin Shi, Xiaoyuan Lv, Fan Li, Songbai Zhang, Songbai Zhang, Yong Liu, Yong Liu, Deyong Zhang, Deyong Zhang   +16 more
doaj   +1 more source

Stress Granules Regulate Double-Stranded RNA-Dependent Protein Kinase Activation through a Complex Containing G3BP1 and Caprin1

mBio, 2015
Stress granules (SGs) are dynamic cytoplasmic repositories containing translationally silenced mRNAs that assemble upon cellular stress. We recently reported that the SG nucleating protein G3BP1 promotes antiviral activity and is essential in double ...
Lucas C. Reineke, N. Kedersha, M. Langereis, F. V. van Kuppeveld, R. Lloyd   +4 more
semanticscholar   +1 more source

Interpretable RNA Foundation Model from Unannotated Data for Highly Accurate RNA Structure and Function Predictions [PDF]

arXiv, 2022
Non-coding RNA structure and function are essential to understanding various biological processes, such as cell signaling, gene expression, and post-transcriptional regulations. These are all among the core problems in the RNA field. With the rapid growth of sequencing technology, we have accumulated a massive amount of unannotated RNA sequences.
arxiv  

Studies on Nucleic Acid Reassociation Kinetics: Retarded Rate of Hybridization of RNA with Excess DNA [PDF]

, 1977
The rate of reaction of excess double-stranded bacteriophage phi X174 and plasmid RSF2124 DNA drivers with enzymatically synthesized asymmetric RNA tracers was measured. Other reactions were carried out with excess Escherichia coli DNA and E.
Britten, Roy J., Davidson, Eric H., Galau, Glenn A., Smith, Michael J.   +3 more
core   +1 more source

Engineering double-stranded RNA binding activity into the Drosha double-stranded RNA binding domain results in a loss of microRNA processing function.

PLoS ONE, 2017
Canonical processing of miRNA begins in the nucleus with the Microprocessor complex, which is minimally composed of the RNase III enzyme Drosha and two copies of its cofactor protein DGCR8.
Joshua C Kranick, Durga M Chadalavada, Debashish Sahu, Scott A Showalter   +3 more
doaj   +1 more source

Production of a Discrete, Infectious, Double-stranded DNA by Reverse Transcription in Virions of Moloney Murine Leukemia Virus [PDF]

, 1979
One of the most unique viral replication schemes is that of the retroviruses (a class that includes the RNA tumor viruses). These viruses synthesize a double-stranded (DS) DNA copy of their single-stranded (SS) RNA genome as the initial event following ...
Baltimore, D., Gilboa, E., Rothenberg, E., Yoshimura, F.   +3 more
core   +1 more source

LL-37 and Double-Stranded RNA Synergistically Upregulate Bronchial Epithelial TLR3 Involving Enhanced Import of Double-Stranded RNA and Downstream TLR3 Signaling

Biomedicines, 2022
The human host defense peptide LL-37 influences double-stranded RNA signaling, but this process is not well understood. Here, we investigate synergistic actions of LL-37 and synthetic double-stranded RNA (poly I:C) on toll-like receptor 3 (TLR3 ...
Sara Bodahl, Samuel Cerps, Lena Uller, Bengt-Olof Nilsson   +3 more
doaj   +1 more source