Results 1 to 10 of about 132,574 (309)

From development to disease: the neuronal role of hnRNPs through the lens of Drosophila [PDF]

Frontiers in Cell and Developmental Biology
Heterogeneous nuclear ribonucleoproteins (hnRNPs) are a large family of RNA-binding proteins (RBPs) involved in multiple aspects of nucleic acid metabolism, ranging from DNA maintenance to RNA splicing and translation.
Chiara Stefanelli, Davide Colaianni, Cristiano De Pittà, Gabriella M. Mazzotta   +3 more
doaj   +2 more sources

HNRNPA2B1 as an emerging coordinator of RNA fate in cancer: m6A reading, RNA export, translation reprogramming, and immune–metabolic adaptation [PDF]

Frontiers in Immunology
Cancer progression and treatment failure are increasingly recognized as consequences of tumor plasticity rather than static genetic alterations. A key component of this plasticity is the ability of cancer cells to reprogram RNA fate, thereby reshaping ...
Wentao Bo, Biao Zhao, Yali Wang, Quan Dai   +3 more
doaj   +2 more sources

Phase separation as an emerging regulatory framework in antibody class switching and genome stability [PDF]

Frontiers in Immunology
The spatial and temporal organization of nuclear processes is increasingly interpreted through principles associated with liquid–liquid phase separation (LLPS), whereby multivalent interactions among proteins and nucleic acids generate dynamic ...
Ahmed M. Refaat, Ahmed M. Refaat, Hidetaka Shimizu, Takaaki Yasuhara   +3 more
doaj   +2 more sources

m6A RNA Methylation Regulators Act as Potential Prognostic Biomarkers in Lung Adenocarcinoma

Frontiers in Genetics, 2021
N6-methyladenosine [m(6)A/m6A] methylation is one of the most common RNA modifications in eukaryotic cell mRNA and plays an important regulatory role in mRNA metabolism, splicing, translocation, stability, and translation.
Hongbo Wang, Xiangxuan Zhao, Zaiming Lu
doaj   +1 more source

Cellular hnRNPAB binding to viral nucleoprotein inhibits flu virus replication by blocking nuclear export of viral mRNA

iScience, 2021
Summary: Heterogeneous nuclear ribonucleoproteins (hnRNPs) play critical roles in the nuclear export, splicing, and sensing of RNA. However, the role of heterogeneous nuclear ribonucleoprotein A/B (hnRNPAB) is poorly understood.
Xingbo Wang, Lulu Lin, Yiye Zhong, Mingfang Feng, Tianqi Yu, Yan Yan, Jiyong Zhou, Min Liao   +7 more
doaj   +1 more source

Sequence- and structure-specific RNA oligonucleotide binding attenuates heterogeneous nuclear ribonucleoprotein A1 dysfunction

Frontiers in Molecular Biosciences, 2023
The RNA binding protein heterogeneous nuclear ribonucleoprotein A1 (A1) regulates RNA metabolism, which is crucial to maintaining cellular homeostasis.
Joseph P. Clarke, Joseph P. Clarke, Patricia A. Thibault, Patricia A. Thibault, Sakina Fatima, Hannah E. Salapa, Hannah E. Salapa, Subha Kalyaanamoorthy, Aravindhan Ganesan, Michael C. Levin, Michael C. Levin, Michael C. Levin, Michael C. Levin   +12 more
doaj   +1 more source

hnRNPA3 regulates hESCs pluripotency through modulating mRNA export [PDF]

Jichu yixue yu linchuang, 2021
Objective To explore the biological function of RNA binding protein heterogeneous nuclear ribonucleoprotein A3(hnRNPA3) in the maintenance of pluripotency of human embryonic stem cells(hESCs) and to reveal its new mechanism in RNA transport.
YANG Jia-bin, CHEN Zhong-yang, ZHOU Fan-qi, YU Jia, MA Yan-ni
doaj  

Single-Cell Transcriptome Analysis Reveals Paraspeckles Expression in Osteosarcoma Tissues

Cancer Informatics, 2022
Nuclear paraspeckles are subnuclear bodies contracted by nuclear-enriched abundant transcript 1 (NEAT1) long non-coding RNA, localised in the interchromatin space of mammalian cell nuclei. Paraspeckles have been critically involved in tumour progression,
Emel Rothzerg, Wenyu Feng, Dezhi Song, Hengyuan Li, Qingjun Wei, Archa Fox, David Wood, Jiake Xu, Yun Liu   +8 more
doaj   +1 more source

Metrizamide dissociates nuclear particles containing heterogeneous nuclear RNA [PDF]

Nucleic Acids Research, 1977
Metrizamide gradients were tested for the possible fractionation of the constitutive units of nuclear particles. Material from 35-55 S monoparticles was indeed distributed along the gradient but rerun experiments, CsCl density determinations, formaldehyde fixation prior to centrifugation suggested that the separation was due to dissociation or (and ...
R, Gattoni, J, Stevenin, M, Jacob
openaire   +2 more sources

A study on the role of long non-coding RNA STMN1P2 in breast cancer and its mechanism [PDF]

Zhongguo aizheng zazhi, 2021
 Background and purpose: Long non-coding RNA (LncRNA) plays a critical role in the malignant progression of tumors. Former study identified lncRNA stathmin 1 pseudogene 2 (STMN1P2) was aberrantly expressed in breast cancer tissues with microarray ...
JIN Youping, LI Luying, ZHOU Ping
doaj   +3 more sources