Results 21 to 30 of about 132,574 (309)

Sorting mRNA Molecules for Cytoplasmic Transport and Localization

Frontiers in Genetics, 2018
In eukaryotic cells, gene expression is highly regulated at many layers. Nascent RNA molecules are assembled into ribonucleoprotein complexes that are then released into the nucleoplasmic milieu and transferred to the nuclear pore complex for nuclear ...
Nathalie Neriec, Piergiorgio Percipalle, Piergiorgio Percipalle   +2 more
doaj   +1 more source

Molecular Mechanisms in Pentanucleotide Repeat Diseases

Cells, 2022
The number of neurodegenerative diseases resulting from repeat expansion has increased extraordinarily in recent years. In several of these pathologies, the repeat can be transcribed in RNA from both DNA strands producing, at least, one toxic RNA repeat ...
Joana R. Loureiro, Ana F. Castro, Ana S. Figueiredo, Isabel Silveira   +3 more
doaj   +1 more source

Arginine methylation in subunits of mammalian pre-mRNA cleavage factor I [PDF]

, 2010
Mammalian cleavage factor I (CF Im) is composed of two polypeptides of 25 kDa and either a 59 or 68 kDa subunit (CF Im25, CF Im59, CF Im68). It is part of the cleavage and polyadenylation complex responsible for processing the 39 ends of messenger RNA ...
Antje Ostareck-Lederer, Neuenkirchen, N., Ostareck-Lederer, Antje, Keller, W., Dettwiler, Sabine, Sabine Dettwiler, Fischer, Utz, Martin, Georges, Rüegsegger, U., Fischer, U., Georges Martin, Ashwin Chari, Blank, Diana, Diana Blank, Neuenkirchen, Nils, Blank, D., Utz Fischer, Chari, Ashwin, Ostareck-Lederer, A., Nils Neuenkirchen, Walter Keller, Chari, A., Ursula Rüegsegger, Dettwiler, S., Martin, G., Keller, Walter, Rüegsegger, Ursula   +26 more
core   +1 more source

Interaction of HnRNP F with the guanine-rich segments in viral antigenomic RNA enhances porcine reproductive and respiratory syndrome virus-2 replication

Virology Journal, 2022
Background Heterogeneous nuclear ribonucleoprotein (HnRNP) F is a member of HnRNP family proteins that participate in splicing of cellular newly synthesized mRNAs by specifically recognizing tandem guanine-tracts (G-tracts) RNA sequences. Whether HnRNP F
Aiguo Zhang, Yanting Sun, Huiyuan Jing, Jie Liu, Erzhen Duan, Wenting Ke, Ran Tao, Yang Li, Jinhe Wang, Sufang Cao, Pandeng Zhao, Haihua Wang, Yan Zhang   +12 more
doaj   +1 more source

Trf4 targets ncRNAs from telomeric and rDNA spacer regions and functions in rDNA copy number control [PDF]

, 2007
Trf4 is the poly(A) polymerase component of TRAMP4, which stimulates nuclear RNA degradation by the exosome. We report that in Saccharomyces cerevisiae strains lacking Trf4, cryptic transcripts are detected from regions of repressed chromatin at ...
Houseley, Jonathan, Kotovic, Kimberly, Tollervey, David, El Hage, Aziz   +3 more
core   +1 more source

Isoforms of U1-70k control subunit dynamics in the human spliceosomal U1 snRNP [PDF]

, 2009
Most human protein-encoding genes contain multiple exons that are spliced together, frequently in alternative arrangements, by the spliceosome. It is established that U1 snRNP is an essential component of the spliceosome, in human consisting of RNA and ...
Nina Morgner, Hernández Helena, Makarov Evgeny M., H. Hernández (7607219), Yutaka Muto, D. P. Krummel (7607234), Helena Hernández, Carol V Robinson, O. V. Makarova (7607222), Robinson, CV, Krummel, DP, Daniel Pomeranz Krummel, Hernandez, H, Evgeny M Makarov, Makarova, OV, Y. Muto (7607231), Olga V Makarova, Robinson Carol V., E. M. Makarov (7607225), N. Morgner (7607228), Makarov, EM, Robinson, Carol, Makarova Olga V., Muto Yutaka, Krummel Daniel Pomeranz, C. V. Robinson (7607237), Morgner, N, Morgner Nina, Muto, Y   +28 more
core   +2 more sources

Metal-ion binding and metal-ion induced folding of the adenine-sensing riboswitch aptamer domain [PDF]

, 2010
Divalent cations are important in the folding and stabilization of complex RNA structures. The adenine-sensing riboswitch controls the expression of mRNAs for proteins involved in purine metabolism by directly sensing intracellular adenine levels ...
Wöhnert, Jens, Schwalbe, Harald (Prof. Dr.), Noeske, Jonas   +2 more
core   +1 more source

Multiplexed imaging of nucleome architectures in single cells of mammalian tissue

Nature Communications, 2020
The three-dimensional architecture of the genome affects genomic functions. Here, the authors developed Multiplexed Imaging of Nucleome Architectures to measure multiscale chromatin folding, RNA profiles, and associations of numerous genomic regions with
Miao Liu, Yanfang Lu, Bing Yang, Yanbo Chen, Jonathan S. D. Radda, Mengwei Hu, Samuel G. Katz, Siyuan Wang   +7 more
doaj   +1 more source

DNA- and RNA-Binding Proteins Linked Transcriptional Control and Alternative Splicing Together in a Two-Layer Regulatory Network System of Chronic Myeloid Leukemia

Frontiers in Molecular Biosciences, 2022
DNA- and RNA-binding proteins (DRBPs) typically possess multiple functions to bind both DNA and RNA and regulate gene expression from more than one level.
Chuhui Wang, Xueqing Zong, Fanjie Wu, Ricky Wai Tak Leung, Ricky Wai Tak Leung, Yaohua Hu, Jing Qin   +6 more
doaj   +1 more source

The function of the protein phosphatase Glc7p in transcription termination, RNA processing and transcriptional regulation of ribosomal protein genes [PDF]

, 2007
Gene transcription in general can be subdivided into three main phases: transcription initiation, elongation and termination. The enzyme that accomplishes transcription of protein coding genes, snRNAs and snoRNAs is RNA polymerase II (RNAP II).
Röck, Salome
core   +1 more source