Results 41 to 50 of about 132,574 (309)

Multi-omics analysis using antibody-based in situ biotinylation technique suggests the mechanism of Cajal body formation

Cell Reports
Summary: Membrane-less subcellular compartments play important roles in various cellular functions. Although techniques exist to identify components of cellular bodies, a comprehensive method for analyzing both static and dynamic states has not been ...
Keisuke Noguchi, Hidefumi Suzuki, Ryota Abe, Keiko Horiuchi, Rena Onoguchi-Mizutani, Nobuyoshi Akimitsu, Shintaro Ogawa, Tomohiko Akiyama, Yoko Ike, Yoko Ino, Yayoi Kimura, Akihide Ryo, Hiroshi Doi, Fumiaki Tanaka, Yutaka Suzuki, Atsushi Toyoda, Yuki Yamaguchi, Hidehisa Takahashi   +17 more
doaj   +1 more source

An analysis of the role of HnRNP C dysregulation in cancers

Biomarker Research, 2022
Heterogeneous nuclear ribonucleoproteins C (HnRNP C) is part of the hnRNP family of RNA-binding proteins. The relationship between hnRNP C and cancers has been extensively studied, and dysregulation of hnRNP C has been found in many cancers. According to
Liyi Mo, Lijuan Meng, Zhicheng Huang, Lan Yi, Nanyang Yang, Guoqing Li   +5 more
doaj   +1 more source

Herpesvirus Replication Compartments: Dynamic Biomolecular Condensates?

Viruses, 2022
Recent progress has provided clear evidence that many RNA-viruses form cytoplasmic biomolecular condensates mediated by liquid–liquid phase separation to facilitate their replication.
Enrico Caragliano, Wolfram Brune, Jens B. Bosse   +2 more
doaj   +1 more source

Oligouridylate stretches in heterogeneous nuclear RNA. [PDF]

Proceedings of the National Academy of Sciences, 1977
Three classes of heterogeneous nuclear RNA (HnRNA) alpha, beta, and gamma, with different chemical and physical properties, can be identified in the early sea urchin embryo by hybridization with poly(U). The relative amounts of these classes vary as a function of embryonic development. It is demonstrated here that the adenyl-containing classes of HnRNA,
openaire   +2 more sources

Transport Granules Bound with Nuclear Cap Binding Protein and Exon Junction Complex Are Associated with Microtubules and Spatially Separated from eIF4E Granules and P Bodies in Human Neuronal Processes

Frontiers in Molecular Biosciences, 2017
RNA transport and regulated local translation play critically important roles in spatially restricting gene expression in neurons. Heterogeneous population of RNA granules serve as motile units to translocate, store, translate, and degrade mRNAs in the ...
Dan O. Wang, Dan O. Wang, Kensuke Ninomiya, Kensuke Ninomiya, Chihiro Mori, Ayako Koyama, Martine Haan, Makoto Kitabatake, Masatoshi Hagiwara, Kazuhiro Chida, Shin-Ichiro Takahashi, Mutsuhito Ohno, Naoyuki Kataoka, Naoyuki Kataoka, Naoyuki Kataoka, Naoyuki Kataoka, Naoyuki Kataoka   +16 more
doaj   +1 more source

An RNA Helicase, DDX1, Interacting with Poly(A) RNA and Heterogeneous Nuclear Ribonucleoprotein K [PDF]

Journal of Biological Chemistry, 2002
Heterogeneous nuclear ribonucleoprotein K (hnRNP K) is a multifunctional protein known to be involved in the regulation of transcription, translation, nuclear transport, and signal transduction. To systematically obtain insight into mechanisms of hnRNP K activities, we set out to identify protein factors that interact with hnRNP K by using glutathione ...
Chen, Hui-Chin, Lin, Wei-Chin, Tsay, Yeou-Guang, Lee, Sheng-Chung, Chang, Ching-Jin   +4 more
openaire   +2 more sources

Heterogeneous nuclear ribonucleoprotein A/B: an emerging group of cancer biomarkers and therapeutic targets

Cell Death Discovery, 2022
Heterogeneous nuclear ribonucleoprotein A/B (hnRNPA/B) is one of the core members of the RNA binding protein (RBP) hnRNPs family, including four main subtypes, A0, A1, A2/B1 and A3, which share the similar structure and functions.
Ya Lu, Xinyue Wang, Quan Gu, Juan Wang, Ying Sui, Jianzhong Wu, Jifeng Feng   +6 more
doaj   +1 more source

Modular RNA interactions shape FXR1 condensates involved in mRNA localization and translation

Nature Communications
Biomolecular condensates are found throughout a diversity of eukaryotic cell types and cellular compartments, playing roles in various cellular functions. A given protein generally forms functionally and compositionally heterogeneous condensates, but the
Jiabin Yang, Zhongyang Chen, Jiayin He, Binbin Zou, Yanmin Si, Yanni Ma, Jia Yu   +6 more
doaj   +1 more source

Valosin‐containing protein counteracts ATP‐driven dissolution of FUS condensates through its ATPase activity in vitro

FEBS Letters, EarlyView.
Biomolecular condensates formed by fused in sarcoma (FUS) are dissolved by high ATP concentrations yet persist in cells. Using a reconstituted system, we demonstrate that valosin‐containing protein (VCP), an AAA+ ATPase, counteracts ATP‐driven dissolution of FUS condensates through its D2 ATPase activity.
Hitomi Kimura, Shin‐ichi Tate, Kyota Yasuda   +2 more
wiley   +1 more source

Organizing the interface—Plasma membrane architecture and receptor dynamics in virus‐cell interactions

FEBS Letters, EarlyView.
Plasma membranes contain dynamic nanoscale domains that organize lipids and receptors. Because viruses operate at similar scales, this architecture shapes early infection steps, including attachment, receptor engagement, and entry. Using influenza A virus and HIV‐1 as examples, we highlight how receptor nanoclusters, multivalent glycan interactions ...
Jan Schlegel, Christian Sieben
wiley   +1 more source